The protective effect of hydrogen sulfide (H2S) on traumatic brain injury (TBI) induced memory deficits in rats

Karimi, Seyed Asaad; Hosseinmardi, Narges; Janahmadi, Mahyar; Sayyah, Mohammad; Hajisoltani, Razieh

doi:10.1016/j.brainresbull.2017.07.014

Cited by 45 publications

(34 citation statements)

References 51 publications

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“…TBI is one of the most common causes of death among youth in today’s world and is considered as a public health epidemic. Memory impairment and cognitive dysfunction are two immediate effects of TBI whereas rapid and extreme production of ROS are also associated with secondary neuronal injury after TBI [ 103 – 106 ]. Karimi et al injected NaHS intraperitoneally and observed neuroprotective effect of H 2 S in TBI induced impaired memory in rats [ 103 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrogen sulfide, nitric oxide, and neurodegenerative disorders

Panthi

Manandhar

Gautam

2018

Transl Neurodegener

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Hydrogen Sulfide (H2S) and Nitric Oxide (NO) have become recognized as important gaseous signaling molecules with enormous pharmacological effects, therapeutic value, and central physiological roles. NO is one of the most important regulators of the pathophysiological condition in central nervous system (CNS). It is critical in the various functioning of the brain; however, beyond certain concentration/level, it is toxic. H2S was regarded as toxic gas with the smell like rotten egg. But, it is now regarded as emerging neuroprotectant and neuromodulator. Recently, the use of donors and inhibitors of these signaling molecules have helped us to identify their accurate and precise biological effects. The most abundant neurotransmitter of CNS (glutamate) is the initiator of the reaction that forms NO, and H2S is highly expressed in brain. These molecules are shedding light on the pathogenesis of various neurological disorders. This review is mainly focused on the importance of H2S and NO for normal functioning of CNS.

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Section: Introductionmentioning

confidence: 99%

Hydrogen sulfide, nitric oxide, and neurodegenerative disorders

Panthi

Manandhar

Gautam

2018

Transl Neurodegener

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“…Acting systemically, H 2 S has been observed to play a neuroprotective role in rats and mice in a traumatic brain injury model . This effect may result from an anti‐inflammatory action of the gas, since H 2 S seems to down‐regulate the expression of NFkappaB in a model of long‐lasting occlusion of the middle cerebral artery .…”

Section: Discussionmentioning

confidence: 99%

“…Acting systemically, H 2 S has been observed to play a neuroprotective role in rats and mice in a traumatic brain injury model. 24,44 This effect may result from an anti-inflammatory action of the gas, since H 2 S seems to down-regulate the expression of NFkappaB in a model of long-lasting occlusion of the middle cerebral artery. 45 Kwiatkosky et al 21 documented that H 2 S is a powerful endogenous antipyretic molecule that may act through suppression of PGE 2 synthesis and/or stimulation of cAMP production in the hypothalamus, based on data obtained using a model of LPS-induced immune challenge.…”

Section: Discussionmentioning

confidence: 99%

Increased hypothalamic hydrogen sulphide contributes to endotoxin tolerance by down‐modulating PGE₂ production

et al. 2019

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Aim Whereas some patients have important changes in body core temperature (Tb) during systemic inflammation, others maintain a normal Tb, which is intrinsically associated to immune paralysis. One classical model to study immune paralysis is the use of repeated administration of lipopolysaccharide (LPS), the so‐called endotoxin tolerance. However, the neuroimmune mechanisms of endotoxin tolerance remain poorly understood. Hydrogen sulphide (H2S) is a gaseous neuromodulator produced in the brain by the enzyme cystathionine β‐synthase (CBS). The present study assessed whether endotoxin tolerance is modulated by hypothalamic H2S. Methods Rats with central cannulas (drug microinjection) and intraperitoneal datalogger (temperature record) received a low‐dose of lipopolysaccharide (LPS; 100 µg kg−1) daily for four consecutive days. Hypothalamic CBS expression and H2S production rate were assessed, together with febrigenic signalling. Tolerant rats received an inhibitor of H2S synthesis (AOA, 100 pmol 1 µL−1 icv) or its vehicle in the last day. Results Antero‐ventral preoptic area of the hypothalamus (AVPO) H2S production rate and CBS expression were increased in endotoxin‐tolerant rats. Additionally, hypothalamic H2S inhibition reversed endotoxin tolerance reestablishing fever, AVPO and plasma PGE2 levels without altering the absent plasma cytokines surges. Conclusion Endotoxin tolerance is not simply a reflection of peripheral reduced cytokines release but actually results from a complex set of mechanisms acting at multiple levels. Hypothalamic H2S production modulates most of these mechanisms.

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“…Apparatus MWM task is a hippocampal-dependent test of spatial learning for rodents (37,38).The water maze apparatus consisted of a black-painted circular pool, (155 cm diameter, 60 cm height), filled to a depth of 35 cm with water (22 ± 1°C). The pool was divided into four equal quadrants.…”

Section: Morris Water Maze (Mwm) Taskmentioning

confidence: 99%

“…The training session was done according to the previous procedure conducted in our laboratory (37,39,40). In summary, training session was consisted of one block of 4 trails per day for four consecutive days.…”

Section: Hidden Platform Trainingmentioning

confidence: 99%

Effects of post-training administration of LY341495, as a mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet

Moridi

Sarihi

Habibitabar

et al. 2020

Preprint

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Background High-fat diets (HFDs) adversely influence glutamate metabolism and neurotransmission. The precise role of the group II metabotropic glutamate receptors (mGluR2/3) antagonist on spatial memory deficit following consumption of HFD has not yet been clarified. Therefore, in this study, we examined the effects of post-training administration of mGluR2/3 antagonism; LY341495 on spatial memory in rats fed with HFD by using Morris Water Maze (MWM) task. Intraperitoneal injection (i.p) injection of LY341495 was done 30 minutes before retention test. Results Our results showed that HFD did not have any effect on memory acquisition. There were not significant differences in escape latency and swimming distance between experimental groups (P>0.05, Two-way ANOVA). Our finding showed that consumption of an HFD leads to spatial memory impairment. There were significant differences in time spent in target zone between experimental groups [F (3, 20) = 7.031, P=0.0021, one-way ANOVA]. Also, LY341495 improved HFD-induced reference memory impairment. HFD animals treated with LY341495 spent more time in the target zone in compare with HFD animals (P= 0.0449). Conclusions Our results suggested that prolonged consumption of high-fat diet has no effects on the acquisition of spatial learning, but can impair memory retention of the adult male rats and post-training administration of LY341495 can improve HFD-induced reference memory impairment.

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The protective effect of hydrogen sulfide (H2S) on traumatic brain injury (TBI) induced memory deficits in rats

Cited by 45 publications

References 51 publications

Hydrogen sulfide, nitric oxide, and neurodegenerative disorders

Hydrogen sulfide, nitric oxide, and neurodegenerative disorders

Increased hypothalamic hydrogen sulphide contributes to endotoxin tolerance by down‐modulating PGE₂ production

Effects of post-training administration of LY341495, as a mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet

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The protective effect of hydrogen sulfide (H2S) on traumatic brain injury (TBI) induced memory deficits in rats

Cited by 45 publications

References 51 publications

Hydrogen sulfide, nitric oxide, and neurodegenerative disorders

Hydrogen sulfide, nitric oxide, and neurodegenerative disorders

Increased hypothalamic hydrogen sulphide contributes to endotoxin tolerance by down‐modulating PGE2 production

Effects of post-training administration of LY341495, as a mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet

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Increased hypothalamic hydrogen sulphide contributes to endotoxin tolerance by down‐modulating PGE₂ production