The Protective Effect of DiDang Tang Against AlCl3-Induced Oxidative Stress and Apoptosis in PC12 Cells Through the Activation of SIRT1-Mediated Akt/Nrf2/HO-1 Pathway

Lü, Jing; Huang, Qingxia; Zhang, Dongmei; Lan, Tianye; Zhang, Ying; Tang, Xiaolei; Xu, Peng; Zhao, Dexi; Cong, Deyu; Zhao, Daqing; Sun, Liwei; Li, Xiangyan; Wang, Jian

doi:10.3389/fphar.2020.00466

Cited by 37 publications

(19 citation statements)

References 60 publications

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“…The extracellular-signal-regulated kinase (ERK) forms a signaling pathway together with Nrf2 [100,101], as does AMPK with Nrf2 [102]. Sirtuin-1 and Nrf2 represent another joint pathway induced by phytochemicals [103].…”

Section: Phytochemicals and Health-a Broader Perspectivementioning

confidence: 99%

Health Effects of Coffee: Mechanism Unraveled?

2020

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The association of habitual coffee consumption with a lower risk of diseases, like type 2 diabetes mellitus, chronic liver disease, certain cancer types, or with reduced all-cause mortality, has been confirmed in prospective cohort studies in many regions of the world. The molecular mechanism is still unresolved. The radical-scavenging and anti-inflammatory activity of coffee constituents is too weak to account for such effects. We argue here that coffee as a plant food has similar beneficial properties to many vegetables and fruits. Recent studies have identified a health promoting mechanism common to coffee, vegetables and fruits, i.e., the activation of an adaptive cellular response characterized by the upregulation of proteins involved in cell protection, notably antioxidant, detoxifying and repair enzymes. Key to this response is the activation of the Nrf2 (Nuclear factor erythroid 2-related factor-2) system by phenolic phytochemicals, which induces the expression of cell defense genes. Coffee plays a dominant role in that regard because it is the major dietary source of phenolic acids and polyphenols in the developed world. A possible supportive action may be the modulation of the gut microbiota by non-digested prebiotic constituents of coffee, but the available data are still scarce. We conclude that coffee employs similar pathways of promoting health as assumed for other vegetables and fruits. Coffee beans may be viewed as healthy vegetable food and a main supplier of dietary phenolic phytochemicals.

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Section: Phytochemicals and Health-a Broader Perspectivementioning

confidence: 99%

Health Effects of Coffee: Mechanism Unraveled?

2020

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“…Currently, aluminum has been reported as an inducer of oxidative stress leading to the appearance of AD markers, so that it has been used to develop rat models of AD (Almuhayawi et al, 2020;Ogunlade et al, 2020). It is also reported that AlCl 3 -induced oxidative stress can lead to apoptosis in PC12 cells (Lu et al, 2020). In this regard, elevated oxidative stress in neurons reduces endogenous antioxidant enzymes such as catalase (CAT), glutathione peroxidase 1 (GPX), and superoxide dismutase 1 (SOD), and there was an increase in activity and levels of iNOS, which in turn produces higher levels of ROS (Guo et al, 2005;Sharma and Mishra, 2006;Sadauskiene et al, 2018;Kinawy, 2019).…”

Section: Discussionmentioning

confidence: 99%

Quercetin-Conjugated Superparamagnetic Iron Oxide Nanoparticles Protect AlCl3-Induced Neurotoxicity in a Rat Model of Alzheimer’s Disease via Antioxidant Genes, APP Gene, and miRNA-101

et al. 2021

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Alzheimer’s disease (AD) is a neurodegenerative disease with cognitive impairment. Oxidative stress in neurons is considered as a reason for development of AD. Antioxidant agents such as quercetin slow down AD progression, but the usage of this flavonoid has limitations because of its low bioavailability. We hypothesized that quercetin-conjugated superparamagnetic iron oxide nanoparticles (QT-SPIONs) have a better neuroprotective effect on AD than free quercetin and regulates the antioxidant, apoptotic, and APP gene, and miRNA-101. In this study, male Wistar rats were subjected to AlCl3, AlCl3 + QT, AlCl3 + SPION, and AlCl3 + QT-SPION for 42 consecutive days. Behavioral tests and qPCR were used to evaluate the efficiency of treatments. Results of behavioral tests revealed that the intensity of cognitive impairment was decelerated at both the middle and end of the treatment period. The effect of QT-SPIONs on learning and memory deficits were closely similar to the control group. The increase in expression levels of APP gene and the decrease in mir101 led to the development of AD symptoms in rats treated with AlCl3 while these results were reversed in the AlCl3 + QT-SPIONs group. This group showed similar results with the control group. QT-SPION also decreased the expression levels of antioxidant enzymes along with increases in expression levels of anti-apoptotic genes. Accordingly, the antioxidant effect of QT-SPION inhibited progression of cognitive impairment via sustaining the balance of antioxidant enzymes in the hippocampus of AD model rats.

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“…8 We also found that the protective effect of Di Dang decoction against AlCl 3-induced oxidative stress and apoptosis in PC12 cells through the activation of SIRT1-Mediated Akt/Nrf2/HO-1pathway. 9 In addition, previous reports showed that leech alcohol extract and rhubarb water extract alleviated the inflammation of peripheral tissue and cerebral edema in rats with ICH. 10,11 Peach seed water extract up-regulated VEGF and VEGF receptor 2 after ICH in a mouse model 6 and inhibited glucose deprivation injury in PC12 cells.…”

Section: Purposementioning

confidence: 96%

“…As our team reported, 8,9 we have established a method for the detection of active ingredients from DDD via highperformance liquid chromatography (HPLC, Agilent, Santa Clara, CA, US). Eighteen major peaks of DDD extract were identified using HPLC.…”

Section: Animal Maintenancementioning

confidence: 99%