The Protective Effect of Daming Capsule on Heart Function in Streptozocin-Induced Diabetic Rats with Hyperlipidemia

Ai, Jing; Yan, Xinxin; Zhao, Limei; Yuan, Linhong; Feng, Liang; Cai, Benzhi; Li, Guoyu; Lu, Yanjie; Yang, Baofeng

doi:10.1248/bpb.32.1354

Cited by 22 publications

(26 citation statements)

References 30 publications

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“…Heart functions of all rats were measured according to our previous study [21]. Systolic blood pressure (SBP) and heart rate (HR) were monitored by a catheter that was inserted through the right common carotid artery and into the left ventricle.…”

Section: Methodsmentioning

confidence: 99%

Blockage of Peripheral NPY Y1 and Y2 Receptors Modulates Barorefex Sensitivity of Diabetic Rats

Liu

Wang²,

Xie³

et al. 2013

Cell Physiol Biochem

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Background/Aims: Abnormal baroreceptor reflex sensitivity (BRS) and elevated plasma neuropeptide Y (NPY) are prevalent in diabetic patients. The present study was conducted to determine whether NPY Y1 receptor (Y1R) and NPY Y2 receptor (Y2R) contribute to the regulatin of BRS in diabetic rats. Methods: Diabetes mellitus (DM) rats with hyperlipidemia were developed by an emulsion diet enriched with fat, sucrose and fructose followed by streptozocin (STZ). Y1R and Y2R specific antagonists (BIBP 3226 and BIIE 0246) were administered by a mini-osmotic pump. Systolic blood pressure (SBP), heart rate (HR), BRS and heart functions, as well as the plasma NPY and lipid level were measured after treatment for 4 weeks. Results: Both BIBP 3226 and BIIE 0246 treatment reversed the elevated total cholesterol (TC) and low density lipoprotein (LDL-C) level, and reduced high density lipoprotein (HDL-C) level in DM rats. BIIE 0246 may attenuate the increased triglyceride (TG) level in DM rats. In addition, neither BIBP 3226 nor BIIE 0246 treatment produced significant effects on BRS, SBP or HR (P>0.05) in DM rats, even after PE and SNP challenge. However, BIBP 3226 and BIIE 0246 further impaired LVSP, LVEDP, +dp/dt_max and -dp/dt_max. Conclusion: This study provided us with the evidence that the inhibition of peripheral Y1R and Y2R did not affect impaired BRS but amplified the deterioration of the compromised cardiac function in STZ-induced DM rats with hyperlipidemia.

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Section: Methodsmentioning

confidence: 99%

Blockage of Peripheral NPY Y1 and Y2 Receptors Modulates Barorefex Sensitivity of Diabetic Rats

Liu

Wang²,

Xie³

et al. 2013

Cell Physiol Biochem

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“…injection. According to previous study [23], cardiac function of all rats was studied. Briefly, arterial blood pressure (ABP) and heart rate (HR) were recorded by inserting the catheter into the left ventricle through the right common carotid artery.…”

Section: Evaluation Of Body Weight Food and Drink Consumption And Bimentioning

confidence: 99%

Neuropeptide Y Reverses Chronic Stress-induced Baroreflex Hypersensitivity in Rats

Xie

Sun

et al. 2012

Cell Physiol Biochem

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Chronic stress, as a risk factor for cardiovascular diseases, has been reported to result in elevated plasma neuropeptide Y (NPY) and be highly associated with abnormal cardiac autonomic function. This study aimed to explore the effect of NPY on the chronic stress-induced abnormal baroreceptor reflex sensitivity (BRS). Seven types of recognized stressors were used to develop chronic stress rat model. Subcutaneously implanting ALZET mini-osmotic pumps containing NPY were used to evaluate the action of NPY on the stressed male rats. We found that chronic stress showed no influence on baseline systolic blood pressure (SBP) and heart rate (HR), whereas NPY (85 µg for 30 days) could elevate baseline SBP and induce bradycardia in rats intervened by various stimuli. NPY pretreatment could preserve chronic stress-induced decreases in left ventricular systolic pressure (LVSP) and the maximum rate of change in left ventricular pressure in the isovolumic contraction period (+dp/dt_max) but has shown no effect on left ventricular end diastolic pressure (LVEDP) and the maximum rate of change in left ventricular pressure in the isovolumic relaxation period (-dp/dt_max). Notably, chronic stress led to baroreflex oversensitivity indicated by the elevated ratio of Δheart rate (HR)/ Δmean arterial blood pressure (MABP) in rats followed by vasoconstrictor (phenylephrine, PE) or vasodilator (sodium nitroprusside, SNP) administration, which was almost completely reversed by NPY pretreatment. The expressions of substance P (SP) and gamma aminobutyric acid A receptor (GABA_AR) in nucleus tractus solitarius were increased in chronic stress rats, which were counteracted by NPY pretreatment. We conclude that chronic stress-induced baroreflex hypersensitivity could be blocked by NPY pretreatment. Furthermore, the altered expressions of neurotransmitters and receptors in the brainstem might contribute to this process.

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“…Cardiac function was calculated as previously described [16] ; briefly, the catheter was inserted into the left ventricle via the right common carotid artery to record cardiac electrophysiologic parameters. Arterial blood pressure (ABP), heart rate (HR), left ventricular systolic pressure (LVSP), left ventricular diastolic pressure (LVEDP) and the maximum rate of change in left ventricular pressure in the isovolumic contraction or relaxation period (±dp/dt max ) were measured using a BL-420 Data Acquisition & Analysis System (Chengdu Tme Technology Co, Ltd, China).…”

Section: Biochemical Indexes Of Bloodmentioning

confidence: 99%

Influence of fluvastatin on cardiac function and baroreflex sensitivity in diabetic rats

Xie

Sun

et al. 2011

Acta Pharmacol Sin

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Aim: To investigate whether fluvastatin is able to ameliorate the impaired cardiac function or baroreflex sensitivity (BRS) in rats with type 1 diabetes. Methods: Type 1 diabetic rats were induced by intraperitoneal injection of streptozotocin (STZ) and then administered fluvastatin (1.5, 3.0, and 6.0 mg·kg -1 ·d -1 ) for 30 d. Food and drink intake was recorded every day. Fasting blood glucose (FBG) level, blood lipid level, cardiac function and BRS were measured in diabetic rats after fluvastatin treatment for 30 d. Results: The polydipsia, polyphagia and abnormal biochemical indexes of blood were significantly ameliorated by the the 3.0-and 6.0-mg doses of fluvastatin in STZ-induced diabetic rats. FBG was decreased in diabetic rats after fluvastatin treatment for 30 d. The left ventricular systolic pressure (LVSP) and the maximum rate of change of left ventricular pressure in the isovolumic contraction and relaxation period (±dp/dt max ) were elevated, and left ventricular diastolic pressure (LVEDP) was decreased by fluvastatin. The attenuated heart rate responses to arterial blood pressure (ABP) increase induced by phenylephrine (PE) and ABP decrease induced by sodium nitroprusside (SNP) were reversed by the 3.0-mg dose of fluvastatin. Conclusion: Fluvastatin regulates blood lipid levels and decreases the FBG level in diabetic rats. These responses can protect the diabetic heart from complications by improving cardiac function and BRS.

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The Protective Effect of Daming Capsule on Heart Function in Streptozocin-Induced Diabetic Rats with Hyperlipidemia

Cited by 22 publications

References 30 publications

Blockage of Peripheral NPY Y1 and Y2 Receptors Modulates Barorefex Sensitivity of Diabetic Rats

Blockage of Peripheral NPY Y1 and Y2 Receptors Modulates Barorefex Sensitivity of Diabetic Rats

Neuropeptide Y Reverses Chronic Stress-induced Baroreflex Hypersensitivity in Rats

Influence of fluvastatin on cardiac function and baroreflex sensitivity in diabetic rats

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