The protective effect of coffee consumption on cutaneous melanoma risk and the role of GSTM1 and GSTT1 polymorphisms

Fortes, Cristina; Mastroeni, Simona; Boffetta, Paolo; Antonelli, Gianluca; Pilla, Maria; Bottà, Giordano; Anzidei, Patrizia; Venanzetti, Federica

doi:10.1007/s10552-013-0255-4

Cited by 20 publications

(16 citation statements)

References 36 publications

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“…The small number or cases in this cohort conferred low power to detect a potential association. Findings on tea consumption from case-control studies have been mixed (Østerlind, 1990;Naldi et al, 2004;Fortes et al, 2008Fortes et al, , 2013. Our findings on consistent tea drinkers are suggestive of a positive relationship between tea intake and melanoma risk, but our main analyses showed no association between tea consumption and melanoma risk and the hypothesized biologic mechanism does not support a positive association between tea intake and melanoma risk.…”

Section: Discussioncontrasting

confidence: 64%

“…Case-control studies are prone to recall bias, in which cases report their exposure to coffee and tea differently in comparison with controls. In addition, all these studies were conducted in different populations, which may not be comparable with our population (Østerlind, 1990;Naldi et al, 2004;Fortes et al, 2008Fortes et al, , 2013. Song et al (2012) reported that higher quintiles of caffeine intake are nonsignificantly associated with an increased risk for melanoma (P for trend =0.09), whereas neither caffeinated nor decaffeinated coffee intake was associated with melanoma risk.…”

Section: Discussionmentioning

confidence: 67%

“…Chemical composition of coffee varies based on the choice of beans and preparation methods (Mills et al, 2013). Case-control studies have also reported an inverse association between coffee consumption and melanoma risk, although results were not always statistically significant (Østerlind, 1990;Naldi et al, 2004;Fortes et al, 2008Fortes et al, , 2013. Case-control studies are prone to recall bias, in which cases report their exposure to coffee and tea differently in comparison with controls.…”

Section: Discussionmentioning

confidence: 99%

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Coffee, tea, and melanoma risk among postmenopausal women

Reeves

Qian

et al. 2015

European Journal of Cancer Prevention

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Laboratory research suggests that components in coffee and tea may have anticarcinogenic effects. Some epidemiologic studies have reported that women who consume coffee and tea have a lower risk for melanoma. We assessed coffee, tea, and melanoma risk prospectively in the Women's Health Initiative - Observational Study cohort of 66,484 postmenopausal women, followed for an average of 7.7 years. Coffee and tea intakes were measured through self-administered questionnaires at baseline and at year 3 of follow-up. Self-reported incident melanomas were adjudicated using medical records. Cox proportional hazard models were used to estimate risk, adjusting for covariates, with person-time accumulation until melanoma diagnosis (n=398), death, loss to follow-up, or through 2005. Daily coffee [hazard ratio (HR)=0.87, 95% confidence interval (CI) 0.68-1.12] and tea (HR=1.03, 95% CI 0.81-1.31) intakes were not significantly associated with melanoma risk compared with nondaily intake of each beverage. No significant trends were observed between melanoma risk and increasing intakes of coffee (P for trend=0.38) or tea (P for trend=0.22). Women who reported daily coffee intake at both baseline and year 3 had a significantly decreased risk compared with women who reported nondaily intake at both time points (HR=0.68, 95% CI 0.48-0.97). Consistent daily tea intake was not associated with decreased melanoma risk. Overall, there is no strong evidence that increasing coffee or tea consumption can lead to a lower melanoma risk. We observed a decrease in melanoma risk among long-term coffee drinkers, but the lack of consistency in the results by dose and type cautioned against overinterpretation of the results.

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Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

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Coffee, tea, and melanoma risk among postmenopausal women

Reeves

Qian

et al. 2015

European Journal of Cancer Prevention

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“…Recent studies variously report an inverse association of melanoma risk with intake of vitamins C, D, and E, soluble carbohydrates, alcohol, and specific foods and beverages such as fish, vegetables, fruit, tea, and coffee (9)(10)(11)(12)(13)(14)(15)(16). Conversely, direct associations have been found with PUFAs, linoleic acid (18:2n-6), and selenium (10-12, 14, 15, 17-20).…”

Section: Introductionmentioning

confidence: 99%

Diet Quality and Risk of Melanoma in an Italian Population

Malagoli

Malavolti

Agnoli

et al. 2015

The Journal of Nutrition

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“…In the most recent study of caffeinated coffee consumption and caffeine from coffee, the protective effect was only for basal cell carcinoma (BCC), which constitutes approximately 80% of non-melanoma skin cancers [30, 31], and not squamous cell carcinoma (SCC) [28]. There was also an inverse association with melanoma for coffee consumption among women, but not men observed in one population in Norway [32, 33] as well as a protective effect of coffee in a mixed gender case-control study in Italy [34]. In addition, while studies of tea and melanoma are sparse, in one case-control study to date there was a borderline statistically significant inverse association [35].…”

Section: Introductionmentioning

confidence: 99%

Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case–control study

Ferrucci

Cartmel

Molinaro

et al. 2014

European Journal of Cancer Prevention

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Objectives Tea and coffee are hypothesized to play a protective role in skin carcinogenesis via bioactive components, such as caffeine, yet the epidemiologic evidence is mixed. Existing data supports an inverse association with basal cell carcinoma (BCC) more so than for melanoma or squamous cell carcinoma. To understand if tea, coffee, and caffeine are related to early-onset BCC, we evaluated data from 767 non-Hispanic Whites under age 40 in a case-control study in Connecticut. Methods BCC cases (n=377) were identified through Yale's Dermatopathology database. Controls (n=390) were randomly sampled from individuals in the same database with benign skin diagnoses and frequency matched to cases on age, gender, and biopsy site. Subjects completed an in-person interview including assessment of caffeinated coffee and hot tea. We calculated multivariate odds ratios (OR) and 95% confidence intervals (CIs) with unconditional logistic regression for regular consumption and frequency and duration measures. Results Combined regular consumption of caffeinated coffee plus hot tea was inversely associated with early-onset BCC (OR=0.60, 95% CI=0.38–0.96). Those in the highest category of caffeine from these sources had a 43% reduced risk of BCC compared to non-consumers (OR=0.57, 95% CI=0.34–0.95, p-trend=0.037). Conclusions Our findings suggest a modest protective effect for caffeinated coffee plus tea in relation to early-onset BCC that may, in part, be due to caffeine. This study adds to the growing body of literature suggesting potential health benefits from these beverages.

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The protective effect of coffee consumption on cutaneous melanoma risk and the role of GSTM1 and GSTT1 polymorphisms

Abstract: Our results show a protective effect of coffee consumption for cutaneous melanoma, in particular for those with homozygous deletion for GSTM1 and GSTT1.

Cited by 20 publications

References 36 publications

Coffee, tea, and melanoma risk among postmenopausal women

Coffee, tea, and melanoma risk among postmenopausal women

Diet Quality and Risk of Melanoma in an Italian Population

Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case–control study

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