2009
DOI: 10.1038/aja.2009.69
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Abstract: The aim of this study was to evaluate the effects of maternal malnutrition during lactation on prostate growth and estradiol serum concentration in the prostate of pups. At delivery, nine Wistar rats were separated into three groups: control group (C) with free access to a standard laboratory diet containing 22% protein; protein-energyrestricted group (PER) with free access to an isoenergy and protein-restricted diet containing 8% protein; and energyrestricted group (ER) receiving standard laboratory diet in r… Show more

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Cited by 9 publications
(12 citation statements)
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“…This observation is in agreement with Zambrano et al (2005) study. Previous study on maternal low protein diet during lactation also observed reduction in the dorsal prostate weight at PND21 (Ramos et al, 2010).…”
Section: Discussionmentioning
confidence: 71%
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“…This observation is in agreement with Zambrano et al (2005) study. Previous study on maternal low protein diet during lactation also observed reduction in the dorsal prostate weight at PND21 (Ramos et al, 2010).…”
Section: Discussionmentioning
confidence: 71%
“…Protein requirement for gestation and lactation as a percentage of the diet is similar for growth of weanling ratsabout 12%when highly digestible protein of balanced amino acid pattern is used (Benevenga et al, 1995). In this sense, fetal programming caused by a maternal low-protein diet affects the development of several organs, including the reproductive system (Leonhardt et al, 2003;Zambrano et al, 2005;Guzman et al, 2006;Faria et al, 2008;Ramos et al, 2010;Qasem et al, 2012). However, the effect of this programming in adulthood and during aging is unclear, in part because of the possibility of reversion or the compensation of these adverse effects observed earlier in life (Langley-Evans and McMullen, 2010).…”
Section: Discussionmentioning
confidence: 99%
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“…Protein‐restricted maternal nutrition during rat gestation or lactation causes a reduction in body and prostate weight . Previous reports demonstrate that this condition decreases estrogen levels , but there is no consensus regarding increased or decreased testosterone levels found in the literature. However, apparently protein restriction during gestation/lactation promotes an imbalance in sexual hormones.…”
Section: Introductionmentioning
confidence: 99%
“…There is wide evidence that an alteration in sex steroid signaling induced by exposure to androgen, estrogen, or endocrine-disrupting chemicals (EDC) in intra-uterine and neonatal life may impact prostate development and alter the susceptibility to prostate disease later in life [20][21][22][23][24][25]. However, the consequences of altered intra-uterine nutrition on prostate maturation and health remain elusive, particularly as regards excessive dietary fat [12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%