The Prophylactic Value of Clean Intermittent Catheterization and Anticholinergic Medication in Newborns and Infants With Myelodysplasia at Risk of Developing Urinary Tract Deterioration

Follow up of meningomyelocele and associated hydrocephalus, bladder and/or bowel incontinence and foot deformity in a developing country

“…[4][5][6] CIC was introduced for maintaining low pressure in neurogenic bladders in 1972. [7][8][9] We have found resolution in all patients of Grade 1 VUR and in 3 patients of Grade 2 VUR. Remaining patients showed lesser grade of VUR on subsequent VCUG.…”

A multinational survey on the management of the urinary tract in newborns with spina bifida: Are we following current EAU/ESPU guidelines?

“…However, the EAU/ESPU guidelines have attempted to cut through this uncertainty. At 6–12 weeks of age, the guidelines recommend starting CAP if there is evidence of VUR on MCUG or evidence of a hostile bladder on VUDs or there is a nonconclusive VUD study 3,10 . A third of respondents in our survey do not follow the guidelines in that they do not routinely commence CAP in their SB patients.…”

“…At 6-12 weeks of age, the guidelines recommend starting CAP if there is evidence of VUR on MCUG or evidence of a hostile bladder on VUDs or there is a nonconclusive VUD study. 3,10 A third of respondents in our survey do not follow the guidelines in that they do not routinely commence CAP in their SB patients. Also, contrary to published literature which suggests that prophylactic antibiotics should be reserved for patients with recurrent febrile UTIs and VUR, 11,12 26% of our respondents opt for a blanket approach and commence CAP on all of their SB patients.…”

The Utility of Urodynamic Studies in Neuro-Urological Patients

“…Improvements in UDS parameters have been highlighted in studies in adults with SCI or MS and children with myelodysplasia. However, not all patients responded to anticholinergic medication, and up to 8% of patients developed UUT changes, indicating the usefulness of surveillance [ 36 , 37 , 38 , 39 ]. Amarenco et al showed that in a population of MS and SCI patients, after 4 weeks of treatment, solifenacin 5 mg PO DIE improved the maximum detrusor pressure (MDP) (−16.6 cmH2O) compared to placebo (+7.5 cmH2O).…”