The properties of bioactive TiO2 coatings on Ti-based implants

Drnovšek, Nataša; Rade, Katja; Milačić, Radmila; Štrancar, Janez; Novak, Saša

doi:10.1016/j.surfcoat.2012.08.037

Cited by 55 publications

(28 citation statements)

References 35 publications

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“…Based on the favourable physical and chemical properties (high adhesion strength, enhanced wetting, decreased release of metal ions), as discussed elsewhere (Drnovšek et al, 2012) and the favourable in vivo behaviour shown here, we can conclude that hydrothermal treatment of Ti6Al4V alloy or porous titanium to form anatase-coating with appropriate, i.e. pinacoidal morphology, offers a simple and cost-effective method for improving osseointegration.…”

Section: Discussionsupporting

confidence: 76%

“…Upon hydrothermal treatment of the alloy, instead of the originally amorphous thin titania layer, a thicker crystalline phase, anatase, is formed. Consequently, the surface becomes more hydrophilic and the release of metallic ions is hindered; in addition, this layer is firmly attached to the substrate (Drnovšek et al, 2012). In this next step, we report on the in vivo behaviour of the anatase coating on the Ti6Al4V alloy and within porous Ti-layer applied on the alloy.…”

Section: Introductionmentioning

confidence: 89%

“…Therefore for the in vivo tests coating with pinacoidal anatase morphology was chosen. Moreover, the anatase coatings improve wetting and hinder the release of aluminium and vanadium ions from the titanium alloy into a physiological solution at 37°C, release of Al and V for non-coated compared to coated was 46.8/27.8 and 2.8/0.7 ng/cm 2 (Drnovšek et al, 2012), respectively. One of the important advantages of the hydrothermally synthesised anatase coating is the ability of the used technique to coat also internal walls of the porous titanium layer applied on Ti-alloy to improve implant fixation into the bone (Drnovšek et al, 2012).…”

Section: Samples Characteristicsmentioning

confidence: 98%

“…The Ti6Al4V cylinders previously coated with a layer of porous titanium (sample 1) were hydrothermally treated to form pinacoidal-type of anatase (sample 2). The more detailed description of procedure to obtain different coating morphology and properties is described elsewhere (Drnovšek et al, 2012).…”

Section: Samples Preparationmentioning

confidence: 99%

“…The physical properties of the anatase-coated Ti-based samples were comprehensively described elsewhere (Drnovšek et al, 2012) where it was showed that the hydrothermally synthesised anatase coatings with thickness up to 1 μm were strongly attached to the substrate and were composed of tightly packed anatase crystals with two major types of morphology: dipyramidal with pronounced {101} facets and pinacoidal (truncated) with pronounced {001} facets. In a simulated body fluid, hydroxyapatite formation is stimulated by the coating when the anatase grains have pinacoidal morphology, while for the non-coated Ti6Al4V alloy and for the alloy coated with dipyramidal anatase no hydroxyapatite was observed.…”

Section: Samples Characteristicsmentioning

confidence: 99%

See 4 more Smart Citations

Improvement of osseointegration of Ti and Ti-alloys by hydrothermally prepared bioactive anatase coating

Drnovšek

Jerman

Romih

et al. 2015

IJNBM

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This paper reports on the in vivo behaviour of Ti6Al4V alloy substrates with or without a porous Ti layer that were coated with a thin layer of anatase TiO 2 by a hydrothermal treatment. In vivo tests were performed on TiO 2 coating with certain morphology, i.e. pinacoidal anatase, which was proven in our previous studies to have better bioactive characteristics then other anatase morphology. A pronounced effect of the hydrothermally prepared TiO 2 coating was seen with the in vivo test where Ti6Al4V implants with a porous Ti layer on the surface were implanted in rabbit tibia for ten weeks. There was a large increase in the amount of mineralised bone within the porous Ti layer when the implant was coated with anatase TiO 2 .

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 89%

Section: Samples Characteristicsmentioning

confidence: 98%

Section: Samples Preparationmentioning

confidence: 99%

Section: Samples Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Improvement of osseointegration of Ti and Ti-alloys by hydrothermally prepared bioactive anatase coating

Drnovšek

Jerman

Romih

et al. 2015

IJNBM

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Systemic effect of TiO₂ micro‐ and nanoparticles after acute exposure in a murine model

et al. 2022

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The surface of a biomedical implant can be a potential endogenous source of release of microparticles (MPs) and nanoparticles (NPs) into the biological environment. In addition, titanium particles from exogenous sources can enter the body through inhalation, ingestion, or dermal contact. The aim of this work was to evaluate the biological response of the lung, liver, and kidneys to acute exposure to titanium dioxide (TiO 2 ). Male Wistar rats were intraperitoneally injected with a suspension of 45 μm or 5 nm TiO 2 particles. One month post-exposure, titanium concentration was determined spectrometrically (ICP-MS) in plasma and target organs. Blood smears and organ tissue samples were examined histopathologically, and oxidative metabolism was analyzed (superoxide anion by nitro blue tetrazolium (NBT) test; superoxide dismutase (SOD) and catalase (CAT); lipid peroxidation; paraoxonase 1). Liver (aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase) and kidney (urea, creatinine) function was evaluated using serum biochemical markers. Microchemical and histological analysis revealed the presence of particles, though no structural alterations, in TiO 2 -exposed groups. NBT test showed an increase in the percentage of reactive cells and antioxidant enzyme consumption in lung samples in the 45 μm and 5 nm TiO 2 -exposed groups. Only the 5 nm particles caused a decrease in SOD and CAT activity in the liver. No changes in renal oxidative metabolism were observed in either of the TiO 2 -exposed groups. Determination of serum biochemical markers and analysis of oxidative metabolism are not early bioindicators of tissue damage caused by TiO 2 MPs and NPs.

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Chronic exposure to TiO₂ micro‐ and nano particles: A biochemical and histopathological experimental study

Domingo,

Kurtz,

Maglione

et al. 2024

J Biomed Mater Res

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The aim of this work was to analyze the effects of long‐term exposure to titanium dioxide (TiO2) micro‐ (MPs) and nanoparticles (NPs) (six and 12 months) on the biochemical and histopathological response of target organs using a murine model. Male Wistar rats were intraperitoneally injected with a suspension of TiO2 NPs (5 nm; TiO2‐NP5 group) or MPs (45 μm; TiO2‐NP5 group); the control group was injected with saline solution. Six and 12 months post‐injection, titanium (Ti) concentration in plasma and target organs was determined spectrometrically (ICP‐MS). Blood smears and organ tissue samples were evaluated by light microscopy. Liver and kidney function was evaluated using serum biochemical parameters. Oxidative metabolism was assessed 6 months post‐injection (determination of superoxide anion by nitroblue tetrazolium (NBT) test, superoxide dismutase (SOD) and catalase (CAT), lipid peroxidation, and paraoxonase 1). Titanium (Ti) concentration in target organs and plasma was significantly higher in the TiO2‐exposed groups than in the control group. Histological evaluation showed the presence of titanium‐based particles in the target organs, which displayed no structural alterations, and in blood monocytes. Oxidative metabolism analysis showed that TiO2 NPs were more reactive over time than MPs (p < .05) and mobilization of antioxidant enzymes and membrane damage varied among the studied organs. Clearance of TiO2 micro and nanoparticles differed among the target organs, and lung clearance was more rapid than clearance from the lungs and kidneys (p < .05). Conversely, Ti concentration in plasma increased with time (p < .05). In conclusion, neither serum biochemical parameters nor oxidative metabolism markers appear to be useful as biomarkers of tissue damage in response to TiO2 micro‐ and nanoparticle deposits at chronic time points.

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The properties of bioactive TiO2 coatings on Ti-based implants

Cited by 55 publications

References 35 publications

Improvement of osseointegration of Ti and Ti-alloys by hydrothermally prepared bioactive anatase coating

Improvement of osseointegration of Ti and Ti-alloys by hydrothermally prepared bioactive anatase coating

Systemic effect of TiO₂ micro‐ and nanoparticles after acute exposure in a murine model

Chronic exposure to TiO₂ micro‐ and nano particles: A biochemical and histopathological experimental study

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The properties of bioactive TiO2 coatings on Ti-based implants

Cited by 55 publications

References 35 publications

Improvement of osseointegration of Ti and Ti-alloys by hydrothermally prepared bioactive anatase coating

Improvement of osseointegration of Ti and Ti-alloys by hydrothermally prepared bioactive anatase coating

Systemic effect of TiO2 micro‐ and nanoparticles after acute exposure in a murine model

Chronic exposure to TiO2 micro‐ and nano particles: A biochemical and histopathological experimental study

Contact Info

Product

Resources

About

Systemic effect of TiO₂ micro‐ and nanoparticles after acute exposure in a murine model

Chronic exposure to TiO₂ micro‐ and nano particles: A biochemical and histopathological experimental study