The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles

Huang, Dong-Ming; Hsiao, Jong‐Kai; Chen, Ying‐Chun; Chien, Li-Ying; Yao, Ming; Chen, Yin‐Kai; Ko, Bor-Sheng; Hsu, Szu-Chun; Tai, Lin-Ai; Cheng, Hong-Jian; Wang, Shih‐Wei; Yang, Chung‐Shi; Chen, Yao‐Chang

doi:10.1016/j.biomaterials.2009.03.032

Cited by 306 publications

(226 citation statements)

References 33 publications

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“…observed an intrinsic peroxidase-like activity for unimpaired IONP in a cell free environment and Huang et al saw the same effect in mesenchymal stem cells, , where IONPs were found to promote cell proliferation 53,54 . Unlike for ROS induction the mechanism behind this protective effect has not yet been unravelled.…”

Section: Common Mechanisms Causing Nanotoxicitymentioning

confidence: 85%

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

et al. 2013

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Section: Common Mechanisms Causing Nanotoxicitymentioning

confidence: 85%

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

et al. 2013

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“…However, the criteria to define toxicity of NPs needs to be clearly defined [22], particularly as emerging studies have begun to highlight aberrant cellular responses including DNA damage, oxidative stress, and mitochondrial membrane Dysfunction.…”

Section: Hematology Findings Of Current Study Inmentioning

confidence: 99%

Treatment of Anemia Progression via Magnetite and Folate NanoparticlesIn Vivo

Elsayed¹,

Al-Sherbini

Abd-Elhady

et al. 2014

ISRN Nanotechnology

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Iron deficiency anemia is a major global public health problem. Food fortification with iron (Fe) can be an effective strategy to control iron deficiency. An iron oxide nanoparticle (NP) is a new physical and chemical property form. These properties (small particle size, unique physical properties) make nanoiron a great scientific interest especially in the treatment of anemia. The study aimed to reduce anemia by nanoparticles (NPs). Forty-eight adult female Sprague-Dewily rats were divided into four groups (12 rats each). Group A represented a negative control. Other groups were fed standard diet iron free and three time of require zinc to reach anemic. Group B fed standard diet with ferrous sulfate until the improvement of the situation of anemia or for 8 weeks. Groups C and D were divided into three subgroups; each subgroup was fed a dose from magnetite or folate coated magnetite NPs. Results showed that symptoms of loss of appetite and severe lethargy demonstrate that magnetite and folate-coated magnetite nanoparticles have serious toxicological effects in vivo. Some doses from NPs improve blood picture during 2 weeks but change in histopathology examinations were occur in some groups within 2 weeks. Nanoparticles were considered the toxicological hazards especially the size of less than 54 nm.

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“…In particular, IONPs can react with hydrogen peroxide and oxygen produced by the mitochondria to give highly reactive hydroxyl radicals and ferric ions (Fe 3+ ) (Singh et al, 2010). In particular, after the internalization into cells, IONPs show an antithetic role or being degraded with the release of free iron in the cytoplasm (Arbab et al, 2003(Arbab et al, , 2005, or possessing an intrinsic peroxidase-like activity (Gao et al, 2007;Huang et al, 2009). For this reason, it is necessary to investigate the presence of ROS to understand the longterm effects of iron-oxide nanoparticles and, consequently, if they should be considered as a hazard (Soenen et al, 2011b).…”

Section: Discussionmentioning

confidence: 99%

Rhamnose‐coated superparamagnetic iron‐oxide nanoparticles: an evaluation of their in vitro cytotoxicity, genotoxicity and carcinogenicity

Paolini

Guarch

Ramos-López

et al. 2015

J of Applied Toxicology

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Tumor recurrence after the incomplete removal of a tumor mass inside brain tissue is the main reason that scientists are working to identify new strategies in brain oncologic therapy. In particular, in the treatment of the most malignant astrocytic tumor glioblastoma, the use of magnetic nanoparticles seems to be one of the most promising keys in overcoming this problem, namely by means of magnetic fluid hyperthermia (MFH) treatment. However, the major unknown issue related to the use of nanoparticles is their toxicological behavior when they are in contact with biological tissues. In the present study, we investigated the interaction of glioblastoma and other tumor cell lines with superparamagnetic iron-oxide nanoparticles covalently coated with a rhamnose derivative, using proper cytotoxic assays. In the present study, we focused our attention on different strategies of toxicity evaluation comparing different cytotoxicological approaches in order to identify the biological damages induced by the nanoparticles. The data show an intensive internalization process of rhamnose-coated iron oxide nanoparticles by the cells, suggesting that rhamnose moiety is a promising biocompatible coating in favoring cells' uptake. With regards to cytotoxicity, a 35% cell death at a maximum concentration, mainly as a result of mitochondrial damages, was found. This cytotoxic behavior, along with the high uptake ability, could facilitate the use of these rhamnose-coated iron-oxide nanoparticles for future MFH therapeutic treatments.

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The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles

Cited by 306 publications

References 33 publications

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

Treatment of Anemia Progression via Magnetite and Folate NanoparticlesIn Vivo

Rhamnose‐coated superparamagnetic iron‐oxide nanoparticles: an evaluation of their in vitro cytotoxicity, genotoxicity and carcinogenicity

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