2019
DOI: 10.1097/meg.0000000000001371
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Abstract: Background Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. The pathogenesis of NAFLD is complex and multifactorial. There is growing evidence that altered gut microbiota plays a key role in NAFLD progression. Probiotics/synbiotics, by modifying gut microbiota, may be a promising treatment choice for NAFLD management. Aim The aim of this study was to study the effect of probiotics/synbiotics on various labo… Show more

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Cited by 36 publications
(27 citation statements)
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“…These mixed results also occurred with other serum markers including Gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting serum glucose (FBS) and inflammatory markers [69,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113]. Given the pattern of mixed results, Table 2 summarizes the most recently published meta-analyses of RCTs with probiotic/synbiotic treatment for NAFLD/NASH populations [114,115,116,117,118].…”
Section: Clinical Application Of Probiotics and Synbiotics In Naflmentioning
confidence: 99%
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“…These mixed results also occurred with other serum markers including Gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting serum glucose (FBS) and inflammatory markers [69,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113]. Given the pattern of mixed results, Table 2 summarizes the most recently published meta-analyses of RCTs with probiotic/synbiotic treatment for NAFLD/NASH populations [114,115,116,117,118].…”
Section: Clinical Application Of Probiotics and Synbiotics In Naflmentioning
confidence: 99%
“…All of the meta-analyses listed indicated that microbial therapies are associated with a significant improvement in ALT and AST [114,115,116,117,118]. Regarding the other serum markers, Liu et al included 15 probiotics and synbiotics RCTs involving 782 patients with NAFLD up to April 2018.…”
Section: Clinical Application Of Probiotics and Synbiotics In Naflmentioning
confidence: 99%
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“…Many studies are of low quality, and variations in formulation, dosage, duration of therapy, and outcome measures often leave one more befuddled than informed. Nevertheless, some positive notes have been struck, most notably in relation to NAFLD and complications of cirrhosis . Encouraging as these observations may be, much remains to be resolved.…”
Section: Interventions That Modulate the Gut Microbiomementioning
confidence: 99%