The promise of protein glycosylation for personalised medicine

Almeida, Andreia; Kolarich, Daniel

doi:10.1016/j.bbagen.2016.03.012

Cited by 76 publications

(72 citation statements)

References 152 publications

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“…It is anticipated that a glycomics approach will also be helpful to forge a link with genomics, lipidomics, proteomics and metabolomics, especially given the fact that the entities measured in the latter 'omics' often contribute to the diversity observed in glycomics [21,114]. Of further relevance, although it has been surmised that glycan levels are to an important extent genetically determined with environmental factors possibly playing a less important role, it is clear that environmental factors such as smoking and alcohol consumption often lead to measurable differences in glycan structure [21,24,115]. Among other challenges, results from glycomics analyses by high-throughput techniques combined with a genomewide association study (GWAS) approach are required to underpin potentially important novel causal pathways in disease development [116].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 98%

“…This may be true for many other circulating inflammatory glycoproteins (Table 1). Given the diversity in the numbers of glycoproteins in biological fluids as well as the unique changes that may occur in some diseases and not others, there is likely a wealth of information yet to be mined from glycoproteins as well as their glycans for clinical use [24].…”

Section: Glycoprotein Biochemistry and Rationale For Measuring Glycopmentioning

confidence: 99%

“…Therefore, glycans are often casual in the disease process and monitoring these changes may provide pertinent information regarding disease stages. In effect, both desirable and undesirable changes in glycan structure may be exploited for risk assessment, patient stratification, diagnostic or prognostic purposes [4,13,18,24,26,27].…”

Section: Glycoprotein Biochemistry and Rationale For Measuring Glycopmentioning

confidence: 99%

“…health, diet, smoking and alcohol consumption) and 6) disease processes (e.g. autoimmune diseases, cancer as well as lowgrade inflammatory diseases such as CVD and T2DM) [21,24].…”

Section: Glycoprotein Biochemistry and Rationale For Measuring Glycopmentioning

confidence: 99%

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Inflammatory glycoproteins in cardiometabolic disorders, autoimmune diseases and cancer

Connelly

Gruppen

Otvos

et al. 2016

Clinica Chimica Acta

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The physiological function initially attributed to the oligosaccharide moieties or glycans on inflammatory glycoproteins was to improve protein stability. However, it is now clear that glycans play a prominent role in glycoprotein structure and function and in some cases contribute to disease states. In fact, glycan processing contributes to pathogenicity not only in autoimmune disorders but also in atherosclerotic cardiovascular disease, diabetes and malignancy. While most clinical laboratory tests measure circulating levels of inflammatory proteins, newly developed diagnostic and prognostic tests are harvesting the information that can be gleaned by measuring the amount or structure of the attached glycans, which may be unique to individuals as well as various diseases. As such, these newer glycan-based tests may provide future means for more personalized approaches to patient stratification and improved patient care. Here we will discuss recent progress in high-throughput laboratory methods for glycomics (i.e. the study of glycan structures) and glycoprotein quantification by methods such as mass spectrometry and nuclear magnetic resonance spectroscopy. We will also review the clinical utility of glycoprotein and glycan measurements in the prediction of common low-grade inflammatory disorders including cardiovascular disease, diabetes and cancer, as well as for monitoring autoimmune disease activity.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 98%

Section: Glycoprotein Biochemistry and Rationale For Measuring Glycopmentioning

confidence: 99%

Section: Glycoprotein Biochemistry and Rationale For Measuring Glycopmentioning

confidence: 99%

“…health, diet, smoking and alcohol consumption) and 6) disease processes (e.g. autoimmune diseases, cancer as well as lowgrade inflammatory diseases such as CVD and T2DM) [21,24].…”

Section: Glycoprotein Biochemistry and Rationale For Measuring Glycopmentioning

confidence: 99%

See 2 more Smart Citations

Inflammatory glycoproteins in cardiometabolic disorders, autoimmune diseases and cancer

Connelly

Gruppen

Otvos

et al. 2016

Clinica Chimica Acta

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“…25,26 To date, one of the most remarkable functions for glycosylation is its role in cell adhesion and migration, specifically in cancer metastasis. [27][28][29][30][31] In addition, glycans have been documented for their role in extracellular matrix (ECM) turnover and remodeling in multiple diseases.…”

Section: Metabolism Glycosylationmentioning

confidence: 99%

Novel Methods in Pulmonary Hypertension Phenotyping in the Age of Precision Medicine (2015 Grover Conference Series)

et al. 2016

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Among pulmonary vascular diseases, pulmonary hypertension (PH) is the best studied and has been the focus of our work. The current classification of PH is based on a relatively simple combination of patient characteristics and hemodynamics. This leads to inherent limitations, including the inability to customize treatment and the lack of clarity from a more granular identification based on individual patient phenotypes. Accurate phenotyping of PH can be used in the clinic to select therapies and determine prognosis and in research to increase the homogeneity of study cohorts. Rapid advances in the mechanistic understanding of the disease, improved imaging methods, and innovative biomarkers now provide an opportunity to define novel PH phenotypes. We have recently shown that altered metabolism may affect nitric oxide levels and protein glycosylation, the peripheral circulation (which may provide insights into the response to therapy), and exhaled-breath analysis (which may be useful in disease evaluation). This review is based on a talk presented during the 2015 Grover Conference and highlights the relevant literature describing novel methods to phenotype pulmonary arterial hypertension patients by using approaches that involve the pulmonary and systemic (peripheral) vasculature. In particular, abnormalities in metabolism, the pulmonary and peripheral circulation, and exhaled breath in PH may help identify phenotypes that can be the basis for a precision-medicine approach to PH management. These approaches may also have a broader scope and may contribute to a better understanding of other diseases, such as asthma, diabetes, and cancer.

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N‐glycome signatures in human plasma: associations with physiology and major diseases

Dotz

Wuhrer

2019

FEBS Letters

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N‐glycome analysis in total plasma or serum yields information about the levels and glycosylation patterns of major plasma glycoproteins, including immunoglobulins, acute‐phase proteins, and apolipoproteins. Until recently, glycomic studies in disease settings largely suffered from small cohort sizes, poor analytical resolution, and poor comparability of results owing to the diversity of analytical techniques. Here, we report on recent advances in high‐throughput mass spectrometry glycomics technology that enabled elucidation of N‐glycome signatures in the plasma of patients with type 2 diabetes, inflammatory bowel disease, or colorectal cancer. Use of this technology revealed both commonalities and differences among disease fingerprints. Moreover, we summarize findings on glycomic signatures associated with age, sex, and body mass index. High‐throughput, high‐resolution glycomics technologies, together with robust data analysis workflows, will advance clinical translation.

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The promise of protein glycosylation for personalised medicine

Cited by 76 publications

References 152 publications

Inflammatory glycoproteins in cardiometabolic disorders, autoimmune diseases and cancer

Inflammatory glycoproteins in cardiometabolic disorders, autoimmune diseases and cancer

Novel Methods in Pulmonary Hypertension Phenotyping in the Age of Precision Medicine (2015 Grover Conference Series)

N‐glycome signatures in human plasma: associations with physiology and major diseases

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