The prognostic role of tumor associated macrophages in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis

Bisheshar, Sangeeta K; Kamp, Martine F. van der; Ruiter, Emma J. de; Ruiter, Lilian N.; Vegt, Bert van der; Breimer, Gerben E.; Willems, Stefan M.

doi:10.1016/j.oraloncology.2022.106227

Cited by 19 publications

(17 citation statements)

References 44 publications

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“…Bisheshar et al emphasize the importance of TAMs, which are associated with worse OS, DFS, and progression-free survival (PFS). [33] Troiano et al found similar results, noting that high stromal expression of CD163 + TAMs correlates with poor OS and PFS. Moreover, the role of TAMs was examined in esophageal cancer, finding that CD68 + TAM density is not associated with esophageal cancer progression.…”

Section: Discussionmentioning

confidence: 79%

Prognostic impact of CD68+ tumor-associated macrophages in hepatocellular carcinoma: A meta-analysis

Jin,

Qian,

Chen

et al. 2024

Medicine

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Background: Evidence from clinical research suggests that the tumor-associated macrophages (TAMs) were associated with prognosis in hepatocellular carcinoma (HCC). The aim of the present meta-analysis was to conduct a qualitative analysis to explore the prognostic value of CD68 + TAMs in HCC. Methods: This study conducted a systematic search in Pubmed, Embase, the Cochrane Library and China National Knowledge Internet from inception of the databases to November 2023. The hazard ratio (HR) and 95% confidence interval (CI) were calculated employing fixed-effect or random-effect models depending on the heterogeneity of the included trials. The Newcastle-Ottawa Scale was used to evaluate the risk of prejudice. Results: We analyzed 4362 HCC patients. The present research indicated that the expression levels Of CD68 + TAMs were significantly associated with overall survival (OS) (HR = 1.55, 95% CI: 1.30–1.84) and disease-free survival (DFS) (HR = 1.44, 95% CI: 1.17–1.78). Subgroup analysis based on cutoff values showed that the “Median” subgroup showed a pooled HR of 1.66 with a 95% CI ranging from 1.32 to 2.08, which was slightly higher than the “Others” subgroup that exhibited a pooled HR of 1.40 and a 95% CI of 1.07 to 1.84. The “PT” subgroup had the highest pooled HR of 1.68 (95% CI: 1.19–2.37), indicating a worse OS compared to the “IT” (pooled HR: 1.50, 95% CI: 1.13–2.01) and “Mix” (pooled HR: 1.52, 95% CI: 1.03–2.26) subgroups. Moreover, in the sample size-based analysis, studies with more than 100 samples (>100) exhibited a higher pooled HR of 1.57 (95% CI: 1.28 to 1.93) compared to studies with fewer than 100 samples (<100), which had a pooled HR of 1.45 (95% CI: 1.00–2.10). Conclusions: The analysis suggests that CD68 + TAMs were significantly associated with unfavorable OS and DFS in HCC patients, and may be served as a promising prognostic biomarker in HCC. However, more large-scale trials are needed to study the clinical value of TAMs in HCC.

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Section: Discussionmentioning

confidence: 79%

Prognostic impact of CD68+ tumor-associated macrophages in hepatocellular carcinoma: A meta-analysis

Jin,

Qian,

Chen

et al. 2024

Medicine

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“…CD204 is recognized as a possible marker for protumoral M2-polarized macrophages in different cancers, in both humans and animals. 6,22,36,42,49 This leads us to postulate that MET infiltration by CD204 + M2-polarized macrophages could be associated with immunoescape processes leading to an immunosuppressed tumor. However, the lack of significantly higher IL10 and TGFB gene expression in equine vulvo-vaginal METs of our study does not seem to support this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

“…The presence of the L1, E2, E6 , and E7 genes of EcPV2 was tested in 19 samples and healthy mucosa. DNA was extracted from two 5-µm-thick sections as previously described 6 and quantified by QUBIT 3 (ThermoFisher Scientific, Waltham, MA, United States). A volume of 100 ng of DNA was used for viral gene detection and for assessing DNA amplifiability by beta-2-microglobulin ( B2M ) gene amplification.…”

Section: Methodsmentioning

confidence: 99%

Vulvo-vaginal epithelial tumors in mares: A preliminary investigation on epithelial-mesenchymal transition and tumor-immune microenvironment

Armando,

Porcellato,

de Paolis

et al. 2023

Vet Pathol

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Vulvo-vaginal epithelial tumors are uncommon in mares, and data on the epithelial-to-mesenchymal transition (EMT) and the tumor-immune microenvironment (TIME) are still lacking. This is a study investigating the equus caballus papillomavirus type 2 (EcPV2) infection state as well as the EMT process and the tumor microenvironment in vulvo-vaginal preneoplastic/ benign (8/22) or malignant (14/22) epithelial lesions in mares. To do this, histopathological, immunohistochemical, transcriptomic, in situ hybridization, and correlation analyses were carried out. Immunohistochemistry quantification showed that cytoplasmic E-cadherin and β-catenin expression as well as nuclear β-catenin expression were features of malignant lesions, while benign/preneoplastic lesions were mainly characterized by membranous E-cadherin and β-catenin expression. Despite this, there were no differences between benign and malignant equine vulvo-vaginal lesions in the expression of downstream genes involved in the canonical and noncanonical wnt/β-catenin pathways. In addition, malignant lesions were characterized by a lower number of cells with cytoplasmic cytokeratin expression as well as a slightly higher cytoplasmic vimentin immunolabeling. The TIME of malignant lesions was characterized by more numerous CD204+ M2-polarized macrophages. Altogether, our results support the hypothesis that some actors in TIME such as CD204+ M2-polarized macrophages may favor the EMT process in equine vulvo-vaginal malignant lesions providing new insights for future investigations in the field of equine EcPV2-induced genital neoplastic lesions.

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“…In addition to causing tumor cell morphological changes, TAMs have been implicated in the regulation of vessel architecture in the tumor stroma. High levels of peri- and intratumoral macrophages are associated with lymph node metastasis and vessel invasion [ 7 , 8 ]. Yamagata et al [ 17 ] showed that CD163 + (M2-like) macrophages were correlated with increased lymphatic vessel density in HNC patient samples, suggesting that they promote lymphangiogenesis, likely through the secretion of vascular endothelial growth factor-C (VEGF-C), a major factor for the growth of lymphatic vasculature.…”

Section: Macrophagesmentioning

confidence: 99%

Exploring the function of myeloid cells in promoting metastasis in head and neck cancer

Okwuone,

Morgan,

Gan

2024

Exploration of Targeted Anti-Tumor Therapy

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Head and neck cancer (HNC) is a challenging disease that lacks effective treatment, particularly in the cases that spread locoregionally and metastasize distantly, dramatically reducing patient survival rates. Expanding the understanding of the mechanisms of the metastatic cascade is critical for creating more effective therapeutics that improve outcomes for HNC patients. A true grasp of cancer metastasis requires the consideration of all cell types that contribute to the inflammatory HNC microenvironment as drivers of this process. More emphasis now is being placed on exploring the roles of the different immune cells in cancer control, tumorigenesis and metastasis. Myeloid cells are the most numerous immune cell types in the body, and they are actively recruited and reprogrammed by tumor cells to behave in a variety of ways. These cells are remarkably diverse in phenotype and function, and the part they play in tumor spread greatly differs based on the cell type. This review will focus on summarizing the roles of macrophages, neutrophils, myeloid derived suppressor cells (MDSCs), and dendritic cells (DCs) in driving HNC metastasis by examining the current knowledge base and offering potential new routes through which to target and treat this deadly process.

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The prognostic role of tumor associated macrophages in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis

Cited by 19 publications

References 44 publications

Prognostic impact of CD68+ tumor-associated macrophages in hepatocellular carcinoma: A meta-analysis

Prognostic impact of CD68+ tumor-associated macrophages in hepatocellular carcinoma: A meta-analysis

Vulvo-vaginal epithelial tumors in mares: A preliminary investigation on epithelial-mesenchymal transition and tumor-immune microenvironment

Exploring the function of myeloid cells in promoting metastasis in head and neck cancer

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