The Prognostic Role of Pretreatment Platelet-to-Lymphocyte Ratio as Predictors in Patients With Colorectal Cancer: A Meta-Analysis

Гао, Мін; Wang, Yonghong; Yao, Nan; Zhao, Jibin; Wang, Jun; Wang, Hongpeng; Chen, Wei; Li, Yumin

doi:10.2217/bmm-2016-0181

Cited by 23 publications

(23 citation statements)

References 29 publications

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“…23 The NLR, PLR and LMR are the most commonly used indicators of systemic inflammatory response and have been reportedly associated with poorer outcomes in CRC patients. 12,24,25 Kilincalp et al analyzed 144 CRC patients and found that the preoperative NLR and PLR were significantly higher in the CRC patients than in 143 age-matched and sexmatched healthy participants, which suggested that the NLR and PLR might be used as potential biomarkers for the detection and monitoring of CRC. 16 Our study indicated the same result that patients with CRC had elevated NLRs and PLRs compared to those in healthy controls.…”

Section: Discussionmentioning

confidence: 99%

<p>Potential Diagnostic Value Of Combining Inflammatory Cell Ratios With Carcinoembryonic Antigen For Colorectal Cancer</p>

Li¹,

Guo²,

Chu³

et al. 2019

CMAR

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To evaluate the diagnostic value of combining the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) or lymphocyte-monocyte ratio (LMR) with carcinoembryonic antigen (CEA) in patients with colorectal cancer (CRC). Patients and methods: The diagnostic performance of inflammatory makers and CEA was evaluated in cohort 1 (664 patients with CRC, 336 patients with colorectal polyps and 664 healthy controls) and validated in cohort 2 (87 patients with CRC and 87 healthy controls) by using receiver operating characteristic curve analysis. Results: In cohort 1, the NLR, PLR and CEA levels were significantly higher, while the LMR was markedly lower in patients with CRC than in healthy controls. The PLR and LMR were significantly associated with invasion depth and lymph node metastasis. Moreover, significant differences in the PLR and LMR were observed between patients with stage I/II CRC and healthy or polyp controls and those with stage III/IV CRC. Using the NLR, PLR or LMR with CEA resulted in a significantly larger area under the curve (AUC) than any of them used alone. Combining the PLR and LMR with CEA exhibited the best diagnostic value for CRC (AUC=0.892). The AUCs of this combination were 0.864 and 0.783 for distinguishing stage I/II CRC from healthy and polyp controls, respectively. When we used the same cutoff values to assess the diagnostic ability of these markers in cohort 2, similar results were observed, and the PLR, LMR and CEA combination also showed the highest accuracy (AUC=0.936). Conclusion: Combining inflammatory cell ratios with CEA could improve the diagnostic efficacy for CRC patients. The combination of the PLR and LMR with CEA might be a valuable indicator in the early detection and monitoring of CRC patients.

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Section: Discussionmentioning

confidence: 99%

<p>Potential Diagnostic Value Of Combining Inflammatory Cell Ratios With Carcinoembryonic Antigen For Colorectal Cancer</p>

Li¹,

Guo²,

Chu³

et al. 2019

CMAR

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“…Tissue specimens allow for the direct examination of tumor and stromal cells. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Although the association between these markers and HNSCC prognosis has been investigated, the results have been inconsistent. However, blood samples can easily be obtained at any time, and blood markers can be measured repeatedly.…”

Section: Introductionmentioning

confidence: 99%

“…14 Platelet count and plateletlymphocyte ratio (PLR) are hematologic makers that have shown prognostic abilities across many types of cancers. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Although the association between these markers and HNSCC prognosis has been investigated, the results have been inconsistent. [34][35][36][37][38][39][40][41][42][43][44][45][46] Among these studies, only 1 study was prospective.…”

Section: Introductionmentioning

confidence: 99%

Platelet count and platelet‐lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: Meta‐analysis

et al. 2018

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“…Other important factors include the increase of platelet-associated inflammatory reactions, decreased antitumor response due to relative scarcity of lymphocytes, and tumoral growth and spread induced by various epithelial and endothelial growth factors secreted by circulating active platelets. 4,5,6,7,8,9,10 When the common effect of age, sex, and comorbid diseases was examined, it was found that PLR was significantly higher in patients with liver metastasis independent of these three parameters (p<0.001). The most important prognostic marker in colon cancer is cancer stage, and liver metastasis detected preoperatively corresponds to a more advanced stage.…”

Section: Discussionmentioning

confidence: 99%

“…The platelet-to-lymphocyte ratio (PLR) has been associated with poor prognosis in many cancers, including colorectal cancer. 6,8,9 Previous studies have focused on changes in PLR at different stages of colon cancer and its effect on prognosis, response to chemotherapy, and recurrence time. 4,5,6,7,8,9,10 In this study, we aimed to determine the utility of PLR at time of admission in predicting hepatic metastasis and lymph node positivity in patients who have undergone colorectal surgery.…”

Section: Introductionmentioning

confidence: 99%

Clinical Value of Platelet-to-Lymphocyte Ratio in Predicting Liver Metastasis and Lymph Node Positivity of Colorectal Cancer Patients

Anuk¹,

Yıldırım²

2017

TJCD

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Amaç: Kolon kanserine bağlı mortalite azalsa da hala yüksektir. Kolonoskopinin artan kullanımı, cerrahi teknolojide ilerlemeler, kemoradyoterapi protokollerinin standardizasyonu metastatik olgularda sağkalımı arttırmıştır. Enflamasyon, birçok kanserin gelişiminde önemli rol oynar. Plateletlenfosit oranı (PLO) gibi birçok belirteç kanserde kötü prognoz ile ilişkilendirilmiştir. Çalışmamızda preoperatif bakılan PLO'nun kolon kanserli hastalarda karaciğer metastazını ve lenf nodu pozitifliğini öngörebilirliğini saptamayı amaçladık. Yöntem: Mart 2010 ve Eylül 2016 tarihleri arasında kolorektal kanser tanısı konularak operasyona alınan hastaların dosyaları retrospektif olarak incelendi. Hastaların demografik verileri, preoperatif PLO, intraoperatif bulgular ve postoperatif tümör-nod-metastaz evrelemesine göre histopatoloji raporları kaydedildi. Hastalar karaciğer metastazı saptananlar grup 1a ve saptanmayanlar grup 1b olarak 2 gruba ayrıldı. Aynı şekilde lenf nodu pozitifliği saptananlar grup 2a ve saptanmayanlar grup 2b olarak alt gruba ayrıldı. Sonuçlar SPSS programı ile analiz edildi. Bulgular: Yüz elli iki hastada erkek/kadın oranı 1,53 idi. En sık rektosigmoid bölgede kanser tespit edildi. Sekiz hastada ailesel kolorektal kanser, 66 hastada komorbid hastalık tespit edildi. Postoperatif 30 günlük dönemde sekiz hastada erken mortalite gözlendi. Otuz bir hastada karaciğer metastazı mevcuttu. PLO'nun gruplar arası karşılaştırmasında, metastaz saptanan grupta PLO değeri, anlamlı şekilde yüksekti (p<0,001). Yaş, cinsiyet ÖZ ABSTRACTAim: Colorectal cancer related mortality is still high. The widespread use of colonoscopy, surgical advancements, and standardized use of chemotherapeutic agents has increased survival rates in metastatic cases. Inflammation is the main etiological factor in a variety of cancers. Plateletto-lymphocyte ratio (PLR), one the most studied biochemical parameters, has been shown as a poor prognostic factor. In this study, our aim was to determine the predictive value of PLR on liver metastasis and lymph node positivity in colorectal patients. Method: The data of patients who were diagnosed with colorectal cancer and underwent surgery between March 2010 and September 2016 were analyzed retrospectively. Demographic characteristics, preoperative PLR, intraoperative findings, and tumor-node-metastasis stages were recorded. Patients with liver metastasis comprised group 1a and those without liver metastasis were group 1b; patients were also sorted into groups 2a and 2b based on lymph node positivity or negativity, respectively. Results: A total of 152 patients were included in the study and the male/female ratio was 1.53. Most of patients had rectosigmoid junction tumors. Eight patients had familial history of colorectal cancer and 66 patients had comorbid conditions. Eight patients had early 30-day mortality. Thirty-one patients had liver metastasis. Patients with liver metastasis (group 1a) had significantly higher PLR values when compared to group 1b (p<0.001). When age, gender and comorbid disease...

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The Prognostic Role of Pretreatment Platelet-to-Lymphocyte Ratio as Predictors in Patients With Colorectal Cancer: A Meta-Analysis

Abstract: This meta-analysis indicated that pretreatment PLR may be a cost-effective and noninvasive serum biomarker for poor prognosis for patients with CRC.

Cited by 23 publications

References 29 publications

<p>Potential Diagnostic Value Of Combining Inflammatory Cell Ratios With Carcinoembryonic Antigen For Colorectal Cancer</p>

<p>Potential Diagnostic Value Of Combining Inflammatory Cell Ratios With Carcinoembryonic Antigen For Colorectal Cancer</p>

Platelet count and platelet‐lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: Meta‐analysis

Clinical Value of Platelet-to-Lymphocyte Ratio in Predicting Liver Metastasis and Lymph Node Positivity of Colorectal Cancer Patients

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