The prognostic factors in sepsis patients after operation of gastrointestinal tumors in ICU

Abstract

<jats:title>Abstract</jats:title> <jats:p><jats:italic>Objectives</jats:italic>:<jats:bold> </jats:bold>We studied the clinical profiles and the prognostic factors in patients with sepsis after thegastrointestinal tumor surgery in ICU.<jats:italic>Methods</jats:italic>: We retrospectively screened patients who underwent the gastrointestinal tumor surgery at the Peking University Cancer Hospital from January 2015 to December 2019. Among them, 181 patients who were diagnosed with sepsis in ICU were enrolled in our study. Cox regression was performed for multivariate adjusted factor analyses.<jats:italic>Results</jats:italic>: The 90-day all-cause mortality rate was 11.1% in our study. The univariate analysis showed that BMI, shock within 48h after entering ICU, number of blood leukocytes, the ratio of lymphocytes to neutrophils, INR, creatinine, procalcitonin, lactic acid, oxygenation index, SOFA score within 24h after entering ICU, APACHE II score within 24h after entering ICU were statistically significant. In multiple analysis, we found that BMI＞20kg/m<jats:sup>2</jats:sup> was a protective factor, while lactic acid＞3 mmol/L after entering ICU and APACHE II score＞20 within 24h after entering ICU were independent risk factors for the prognosis of sepsis after the gastrointestinal tumor surgery in ICU. <jats:italic>Conclusions</jats:italic>:<jats:bold> </jats:bold>The 90-day all-cause mortality rate was 11.1% in our study. BMI＞20kg/m<jats:sup>2</jats:sup> was a protective factor, while lactic acid＞3 mmol/L after entering ICU and APACHE II score＞20 within 24h after entering ICU were independent risk factors for the prognosis of sepsis after the gastrointestinal tumor surgery in ICU.</jats:p>