volume 7, issue 1, P53-69 2015
DOI: 10.18632/aging.100721
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Gary N. Landis, Matthew P. Salomon, Daniel Keroles, Nicholas Brookes, Troy Sekimura, John Tower

Abstract: Mating causes decreased life span in female Drosophila. Here we report that mifepristone blocked this effect, yielding life span increases up to +68%. Drug was fed to females after mating, in the absence of males, demonstrating function in females. Mifepristone did not increase life span of virgin females or males. Mifepristone reduced progeny production but did not reduce food intake. High-throughput RNA sequencing was used to identify genes up-regulated or down-regulated upon mating, and where the change was…

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