The Primary Motor Cortex Stimulation Attenuates Cold Allodynia in a Chronic Peripheral Neuropathic Pain Condition in &amp;lt;i&amp;gt;Rattus norvegicus&amp;lt;/i&amp;gt;

Santos

et al. 2020

Braz J Med Biol Res

The neurochemical mechanisms underlying neuropathic pain (NP) are related to peripheral and central sensitization caused by the release of inflammatory mediators in the peripheral damaged tissue and ectopic discharges from the injured nerve, leading to a hyperexcitable state of spinal dorsal horn neurons. The aim of this work was to clarify the role played by cyclooxygenase (COX) in the lesioned peripheral nerve in the development and maintenance of NP by evaluating at which moment the nonsteroidal anti-inflammatory drug indomethacin, a non-selective COX inhibitor, attenuated mechanical allodynia after placing one loose ligature around the nervus ischiadicus, an adaptation of Bennett and Xie's model in rodents. NP was induced in male Wistar rats by subjecting them to chronic constriction injury (CCI) of the nervus ischiadicus, placing one loose ligature around the peripheral nerve, and a sham surgery (without CCI) was used as control. Indomethacin (2 mg/kg) or vehicle was intraperitoneally and acutely administered in each group of rats and at different time windows (1, 2, 4, 7, 14, 21, and 28 days) after the CCI or sham surgical procedures, followed by von Frey's test for 30 min. The data showed that indomethacin decreased the mechanical allodynia threshold of rats on the first, second, and fourth days after CCI (Po0.05). These findings suggested that inflammatory mechanisms are involved in the induction of NP and that COX-1 and COX-2 are involved in the induction but not in the maintenance of NP.

Section: Neuropathic Pain Inductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury

Santos

et al. 2020

Braz J Med Biol Res

“…There are functional and metabolic similarities between neuropathic pain and post-traumatic stress disorder, with the mPFC playing a key role in integrating the disorder and comorbidities (Feldman, 2004 ). There are reports in the literature showing in both human patients and laboratory animals that the presence of chronic pain causes changes in functional reorganisations in cortical and subcortical structures, including the mPFC (Apkarian et al, 2009 ; Baliki et al, 2006 ; Medeiros et al, 2019a , b , c ; Malvestio et al, 2021 ; Metz et al, 2009 ), dorsal thalamus (Apkarian et al, 2004 ), amygdaloid complex (Han et al, 2005 ; Ji et al, 2010 ), and anterior cingulate cortex (ACC) (Li et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Physical, Emotional, and Social Pain During COVID-19 Pandemic-Related Social Isolation

Coimbra

et al. 2022

Trends in Psychol.

Self Cite

The socio-emotional condition during the COVID-19 pandemic subsidises the (re)modulation of interactive neural circuits underlying risk assessment behaviour at the physical, emotional, and social levels. Experiences of social isolation, exclusion, or affective loss are generally considered some of the most “painful” things that people endure. The threats of social disconnection are processed by some of the same neural structures that process basic threats to survival. The lack of social connection can be “painful” due to an overlap in the neural circuitry responsible for both physical and emotional pain related to feelings of social rejection. Indeed, many of us go to great lengths to avoid situations that may engender these experiences. Accordingly, this work focuses on pandemic times; the somatisation mentioned above seeks the interconnection and/or interdependence between neural systems related to emotional and cognitive processes such that a person involved in an aversive social environment becomes aware of himself, others, and the threatening situation experienced and takes steps to avoid daily psychological and neuropsychiatric effects. Social distancing during isolation evokes the formation of social distress, increasing the intensity of learned fear that people acquire, consequently enhancing emotional and social pain.

“…A dor, enquanto objeto de estudo, foi induzida nos roedores a partir de uma cirurgia adaptada, a qual promove uma lesão periférica no nervo ciático. O modelo original, proposto por Bennett & Xie (1988) (BENNETT; XIE, 1988) de quatro ligaduras foi adaptado por Medeiros e colaboradores (2020a, 2021) a uma única ligadura (MEDEIROS et al, 2019a(MEDEIROS et al, , 2019b(MEDEIROS et al, , 2020a(MEDEIROS et al, , 2020b(MEDEIROS et al, , 2020c(MEDEIROS et al, , 2021. A partir desta única ligadura foi demonstrado alterações de limiares nociceptivos bem como alterações comportamentais relacionadas a ansiedade, depressão e cognição, mas sem afetar a capacidade locomotora ou provocar comportamento de autotomia (MEDEIROS et al, 2021).…”

Section: Discussionunclassified

Estudo do efeito do canabidiol e do envolvimento dos receptores CB1 e 5-HT1A na conexão córtex pré-frontal medial e hipocampo dorsal sobre os aspectos cognitivos e emocionais na dor neuropática crônica em ratos

Medeiros¹

Self Cite

Estudo do efeito do canabidiol e do envolvimento dos receptores CB1 e 5-HT1A na conexão córtex pré-frontal medial e hipocampo dorsal sobre os aspectos cognitivos e emocionais na dor neuropática crônica em ratos Ribeirão Preto -SP 2021 2 ANA CAROLINA MEDEIROS Estudo do efeito do canabidiol e do envolvimento dos receptores CB1 e 5-HT1A na conexão córtex pré-frontal medial e hipocampo dorsal sobre os aspectos cognitivos e emocionais na dor neuropática crônica em ratos