1999
DOI: 10.1016/s0969-2126(99)80019-7
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Abstract: This is the first known three-dimensional structure in which multiple copies of a tetrahaem cytochrome c3-like fold are present in the same polypeptide chain. Sequence homology was found between this cytochrome and the C-terminal region (residues 229-514) of the high molecular weight cytochrome c from Desulfovibrio vulgaris Hildenborough (DvH Hmc). A new haem arrangement in domains III and IV of DvH Hmc is proposed. Kinetic experiments showed that 9Hcc can be reduced by the [NiFe] hydrogenase from D. desulfuri… Show more

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Cited by 75 publications
(74 citation statements)
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“…The structure of the Desulfovibrio desulfuricans ATCC 27774 (Dd27k) 9HcA cytochrome revealed that this cytochrome is also composed of two tetraheme motifs with an isolated heme (heme 4 of 9HcA) between them (16). Furthermore, sequence alignment between the 9HcA and the last two domains of DvH HmcA indicated a high similarity between them and led to the proposal that heme 11 of Hmc would be an isolated heme between the last two domains and that heme 15 would be the high-spin heme (16). All these predictions have been confirmed in the present structure.…”
Section: Resultssupporting
confidence: 78%
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“…The structure of the Desulfovibrio desulfuricans ATCC 27774 (Dd27k) 9HcA cytochrome revealed that this cytochrome is also composed of two tetraheme motifs with an isolated heme (heme 4 of 9HcA) between them (16). Furthermore, sequence alignment between the 9HcA and the last two domains of DvH HmcA indicated a high similarity between them and led to the proposal that heme 11 of Hmc would be an isolated heme between the last two domains and that heme 15 would be the high-spin heme (16). All these predictions have been confirmed in the present structure.…”
Section: Resultssupporting
confidence: 78%
“…The three cytochromes HmcA, 9HcA, and TpII-c 3 share a common electron donor, the TpI-c 3 , which acts as a mediator for electron transfer from hydrogenases. Indeed, catalytic amounts of this cytochrome increase the rate of reduction of either HmcA, 9HcA, or TpII-c 3 by hydrogenases (16,18,26). This is particularly true in the case of DvH HmcA for which reduction by either of the three hydrogenases is extremely slow in the absence of TpI-c 3 (26).…”
Section: Resultsmentioning
confidence: 99%
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