The prevalence of thyroid dysfunction and autoimmune thyroid disease in patients with rheumatoid arthritis

Bagherzadeh-Fard, Mahsa; Yazdanifar, Mohammad Amin; Aghaali, Mohammad; Masoumi, Maryam

doi:10.1186/s41927-022-00293-9

Cited by 7 publications

(6 citation statements)

References 31 publications

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“…They examined 35,708 cases of patients in terms of possible coexistence of RA and thyroid disorders, confirming the high incidence of AID, especially hypothyroidism, in this group of patients. Bagherzadeh-Fard et al [8] also found that there were twice as many cases of AITD coexistence with RA as in a control group.…”

Section: Rheumatoid Arthritismentioning

confidence: 89%

Autoimmune polyendocrine syndromes associated with autoimmune rheumatic diseases

Jankowska,

Dudek,

Stasiek

et al. 2023

Reumatologia

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Autoimmune polyendocrine syndromes (APSs), also called autoimmune polyglandular syndromes, are a group of autoimmune diseases characterized by the co-occurrence of dysfunctions of several (at least two) endocrine glands. They develop under the influence of environmental factors in genetically predisposed people. Autoimmune polyendocrine syndromes may accompany autoimmune rheumatic diseases and worsen their course – APS-2 and APS-3 are the most common. The APS-2 includes the coexistence of, e.g. Hashimoto’s disease, celiac disease and rheumatoid arthritis (RA). In APS-3, rheumatic diseases such as RA, systemic lupus erythematosus, and Sjögren’s syndrome may coexist with Hashimoto’s disease, type 1 diabetes and hypogonadism or other endocrinopathies. Undiagnosed endocrine diseases may be the reason for the intensification of metabolic disorders observed in the course of rheumatic diseases, cause the ineffectiveness of rheumatological treatment and also increase the frequency of bone fractures due to osteoporosis, cardiovascular complications and even miscarriages when coexistent, e.g. Hashimoto’s disease with hypothyroiditis, which increases the risk of pregnancy loss. It is important to be able to conduct an extensive interview, paying attention to the symptoms of possible endocrinopathy as well as the features of other autoimmune disorders in the physical examination (e.g. vitiligo or darkening of the skin in Addison’s disease). Depending on the history and physical examination, screening for various APSs is advised.

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Section: Rheumatoid Arthritismentioning

confidence: 89%

Autoimmune polyendocrine syndromes associated with autoimmune rheumatic diseases

Jankowska,

Dudek,

Stasiek

et al. 2023

Reumatologia

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“…Research shows that the STAT4, HLA-DRB1 genes and vitamin D receptors (present in B and T lymphocytes) play a particularly important role in the development of both diseases. A correlation between the occurrence of a positive anti-TPO antibody titer and the exacerbation and more severe clinical course of RA has also been documented [46,47]. Type 1 diabetes is a metabolic disorder associated with the destruction of insulin-producing pancreatic β cells by autoantibodies.…”

Section: Hashimoto's Thyroiditis and Other Autoimmune Diseases -T1d R...mentioning

confidence: 98%

Understanding the Challenges of Hashimoto's Thyroiditis: Perspectives on Diagnosis, Treatment, and Associated Conditions

Kułak,

Palacz,

Gadżała

et al. 2024

J Educ Health Sport

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Introduction: Hashimoto's thyroiditis is a prevalent autoimmune disease among the population. With the progress in diagnostic and research techniques, it has come to light that Hashimoto's thyroiditis is linked to a higher likelihood of developing other disorders that impact multiple organs and systems. Throughout the course of this disease, individuals may experience an array of complications such as sexual dysfunctions, fertility problems, specific mental disorders, cardiovascular diseases and other autoimmune diseases. Aim of the Study: The primary aim of this study is to explore the potential association between Hashimoto’s thyroiditis and its consequential effects on other physiological systems and organs. Description of the State of Knowledge: Hashimoto's thyroiditis is a complex autoimmune disease characterized by chronic inflammation of the thyroid gland. The pathogenesis of the disease is not yet completely understood. Hashimoto's thyroiditis has been associated with a range of health issues, including sexual dysfunction, fertility problems, psychiatric disorders, cardiovascular diseases, and other autoimmune disorders. Materials and methods: An unsystematic scientific literature review was conducted using specific keywords such as Hashimoto's thyroiditis, fertility problems, thyroid tumor, cardiovascular diseases, and autoimmune diseases. The review was carried out on PubMed, analyzing a total of 53 sources published until 2023. Conclusions: HT's association with psychiatric disorders, fertility issues, thyroid tumors, cardiovascular dysfunction, and comorbid autoimmune conditions underscores its broad clinical impact, necessitating integrated management approaches. Effective management of HT requires collaboration among specialists to ensure early detection, proactive intervention, and patient education, ultimately improving therapeutic outcomes and quality of life.

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“…They found that post-thyroidectomy TPOAb levels decreased from a mean of 339 to 59 IU/L, and there were major improvements in patients’ associated autoimmune features including RA [ 61 ]. These common and overlapping immune activation pathways may help to explain the reported exacerbation of disease activity in patients with an RA and AITD overlap [ 62 , 63 ].…”

Section: Effect Of Aitd On Ra Disease Activitymentioning

confidence: 99%

Autoimmune thyroid disease and rheumatoid arthritis: where the twain meet

Lichtiger,

Fadaei,

Tagoe

2024

Clin Rheumatol

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Autoimmune thyroid disease (AITD) is the most prevalent autoimmune disease. It shares multiple genetic, clinical, and serologic characteristics with rheumatoid arthritis (RA). Although frequently described as a classic form of single-organ autoimmunity, the AITD disease burden in a subset of patients extends well beyond the thyroid gland. This review explores the complex interaction between the two diseases and the clinical consequences when they overlap. Beyond the well-known effects of AITD on thyroid function in RA, there is mounting evidence of the association of both conditions impacting the presentation and outcomes of diabetes, metabolic syndrome, and cardiovascular disease. An increasing number of studies suggest that there are negative effects of AITD on RA disease activity both in the presence and in the absence of thyroid dysfunction. Recent evidence suggests that AITD may not only worsen the cumulative damage of RA through higher disease activity but may also worsen secondary osteoarthritis changes. Less well-known is the significant association between AITD and chronic widespread pain syndromes including fibromyalgia. Importantly, the presence of fibromyalgia, which is increased in RA patients, appears to be further increased when it overlaps with AITD. Lastly, we probe the possible influence of AITD interacting with RA on fertility and clinical depression. Key Points• Autoimmune thyroid disease is the most common autoimmune disease and is frequently associated with rheumatoid arthritis.• Autoimmune thyroid disease can present with osteoarthritis, inflammatory arthritis, and chronic widespread pain syndromes.• The co-occurrence of autoimmune thyroid disease and rheumatoid arthritis may worsen disease activity and exacerbate other disease manifestations including cardiovascular disease, fertility, and depression.• The overlap of rheumatoid arthritis with autoimmune thyroid disease needs further research and should be sought in general clinical practice.

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The prevalence of thyroid dysfunction and autoimmune thyroid disease in patients with rheumatoid arthritis

Cited by 7 publications

References 31 publications

Autoimmune polyendocrine syndromes associated with autoimmune rheumatic diseases

Autoimmune polyendocrine syndromes associated with autoimmune rheumatic diseases

Understanding the Challenges of Hashimoto's Thyroiditis: Perspectives on Diagnosis, Treatment, and Associated Conditions

Autoimmune thyroid disease and rheumatoid arthritis: where the twain meet

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