The prevalence of hyperuricemia and its correlates in an inland Chinese adult population, urban and rural of Jinan

Abstract

Economy has developed rapidly in China, and the clustering of cardiovascular risk factors in subjects increased remarkably over the past two decades. However, no data are available regarding the temporal prevalence of hyperuricemia and its correlates in this rapidly developing area, especially in the inland area. The cross-sectional survey was based on a random sample of 4,218 residents aged 35-64 years in the Jinan area. Hyperuricemia was defined as serum uric acid ≥ 416 μmol/L in men and ≥ 357 μmol/L in women. Subjects underwent physical examination and fasting blood testing. Complete data were available for analysis from 1,979 men and 2,062 women. The age-adjusted prevalence of hyperuricemia was 6.4 % for men and 2.1 % for women. The prevalence of hyperuricemia was greater in urban (6.7 %) than in rural areas (1.7 %) of Jinan city. Multivariate logistic regression models revealed hyperuricemia associated with hypertriglyceridemia [men: odds ratio (OR) = 6.101, 95 % confidence interval (CI) 4.064-9.159; women: OR = 7.103, 95 % CI 3.578-14.099] and high serum creatinine level (men: OR = 2.603, 95 % CI 1.602-4.230; women: OR = 5.237, 95 % CI 2.667-10.284). Hyperuricemia was also significantly associated with male sex, urban residence, hypertension, obesity, and hypercholesterolemia. Age (1-year increase) was negatively associated with hyperuricemia in men but positively associated with hyperuricemia in women. In conclusion, the prevalence of hyperuricemia is higher in urban than rural areas of Jinan, China. Male sex, urban residence, hypertension, obesity, hypercholesterolemia, hypertriglyceridemia, and high serum creatinine level contributed to hyperuricemia in this population.

Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians

“…[44][45][46] Studies in rodents and other molecular observations indicate an important role for SLC2A9 in proximal tubular urate absorption. 47,48 Genome-wide (GWAS) and candidate association studies have found strong association of SLC2A9 SNPs with SUA levels.…”

Prevalence and Metabolic Factors of Hyperuricemia in an Elderly Agricultural and Fishing Population in Taiwan

“…11,[21][22][23] The mechanism underlying the slightly lower prevalence of hyperuricemia in males aged ≥85 than in those aged 75-84 years remains unclear; nevertheless, in females, the increase in hyperuricemia prevalence with increasing age may be explained by postmenopausal changes in the endocrine system and estrogen levels. 22 Consistent with other studies, 21,22,25 we observed a positive association between hyperuricemia and metabolic disorders in our Chinese population. Epidemiological studies have also reported an association between hyperuricemia and metabolic disorders such as metabolic syndrome, hyperlipidemia, obesity, and type 2 diabetes.…”

“…Epidemiological studies have also reported an association between hyperuricemia and metabolic disorders such as metabolic syndrome, hyperlipidemia, obesity, and type 2 diabetes. 11,22,25 Metabolic syndrome is a cluster of three diseases-hypertension, hyperglycemia, and gout, 11 Although metabolic syndrome is clearly associated with obesity, insulin resistance, and abnormal blood lipids, which lead to the three diseases, the etiological mechanisms of this 26 Previous studies have indicated that serum uric acid level can be used as a crucial predictor of metabolic syndrome and that the number of metabolic syndrome components increases the prevalence and OR for significantly increased uric acid activity. 11,27,28 Among patients with chronic hepatitis, fructose load may cause a substantial increase in serum uric acid levels.…”

“…The prevalence of hyperuricemia among different screened populations seems to vary between countries. [16][17][18][19][20][21][22][23][24][25] This disparity is likely due to differences among various populations with regard to participant characteristics (e.g., age, socioeconomic status, and abnormal associated factors), study period, and different diagnostic definitions for elevated serum uric acid levels. The prevalence of hyperuricemia in our study population (30.4%) was higher than that reported in previous population-based studies conducted in general Chinese populations.…”

“…The prevalence of hyperuricemia in our study population (30.4%) was higher than that reported in previous population-based studies conducted in general Chinese populations. 11,16,[20][21][22]25 The agricultural and fishing population endures strenuous working conditions, job stress, and reversed working and resting times compared to those of the general population. 5 Irregular lifestyles and carelessness regarding personal health are also major problems in this population.…”