The prevalence of HIV among patients admitted with stroke at the Muhimbili National Hospital, Dar es Salaam, Tanzania

Mlay, Mathew G.; Bakari, Muhammad

doi:10.4314/thrb.v12i2.56397

Cited by 23 publications

(27 citation statements)

References 35 publications

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“…In line with previous reports, stroke patients with HIV were younger and a higher proportion were male, compared to those without HIV infection [2,6,9,10]. Traditional stroke risk factors were more prevalent in the non-HIV group, whilst anaemia was more prevalent in the HIV group [11]. We demonstrate a higher rate of post-stroke complications in patients with HIV and, to our knowledge, are the first group to specifically report this.…”

Section: Discussionsupporting

confidence: 92%

“…Unfortunately, data on precise cause of death, was not available from our data set and so was not accounted for in this analysis. In keeping with the higher prevalence of complications found here, and with previous literature, mean LOS was longer in HIV patients, particularly those with ischaemic stroke [11].…”

Section: Discussionsupporting

confidence: 92%

“…The higher risk of mortality in stroke in HIV (fully adjusted OR 2·20) has previously been found, but is not consistent with all literature [10,11,18]. These smaller single centre studies may have lacked power to detect statistically significant findings.…”

Section: Discussionsupporting

confidence: 90%

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Impact of HIV on inpatient mortality and complications in stroke in Thailand: a National Database Study

et al. 2017

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

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Impact of HIV on inpatient mortality and complications in stroke in Thailand: a National Database Study

et al. 2017

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“…When AIDS-defining illnesses are excluded, however, similar clinical and angiographic findings to those who are HIV seronegative are seen 59. HIV is not in itself associated with worse outcome from stroke62; however, there may be a poor prognosis when there is associated fever 60…”

Section: Cerebrovascular Diseasementioning

confidence: 99%

“…Although AIDS has been associated with both ischaemic and haemorrhagic stroke,58 this has not been demonstrated in non-AIDS patients with HIV,59 although patients with HIV tend to be younger and fewer have hypertension 60. The majority of stroke in patients with HIV in sub-Saharan Africa is ischaemic in aetiology 59 61.…”

Section: Cerebrovascular Diseasementioning

confidence: 99%

Recent advances in HIV-associated cardiovascular diseases in Africa

Syed

Sani

2013

Heart

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The last decade has witnessed major advances in our understanding of the epidemiology and pathophysiology of HIV-related cardiovascular disease in sub-Saharan Africa. In this review, we summarise these and discuss clinically relevant advances in diagnosis and treatment. In the Heart of Soweto Study, 10% of patients with newly diagnosed cardiovascular disease were HIV positive, and the most common HIV-related presentations were cardiomyopathy (38%), pericardial disease (13%) and pulmonary arterial hypertension (8%). HIV-related cardiomyopathy is more common with increased immunosuppression and HIV viraemia. With adequate antiretroviral therapy, the prevalence is low. Contributing factors such as malnutrition and genetic predisposition are under investigation. In other settings, pericardial disease is the most common presentation of HIV-related cardiovascular disease (over 40%), and over 90% of pericardial effusions are due to Mycobacterium tuberculosis (TB) pericarditis. HIV-associated TB pericarditis is associated with a greater prevalence of myopericarditis, a lower rate of progression to constriction, and markedly increased mortality. The role of steroids is currently under investigation in the form of a randomised controlled trial. HIV-associated pulmonary hypertension is significantly more common in sub-Saharan Africa than in developed countries, possibly as a result of interactions between HIV and other infectious agents, with very limited treatment options. It has recently been recognised that patients with HIV are at increased risk of sudden death. Infection with HIV is independently associated with QT prolongation, which is more marked with hepatitis C co-infection and associated with a 4.5-fold higher than expected rate of sudden death. The contribution of coronary disease to the overall burden of HIV-associated cardiovascular disease is still low in sub-Saharan Africa.

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Analysis of the demographic characteristics and clinical profile of acute ischemic strokes admitted to the emergency centre in the Somalia population

Arslan¹,

Cetinkaya²

2022

African Journal of Emergency Medicine

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The prevalence of HIV among patients admitted with stroke at the Muhimbili National Hospital, Dar es Salaam, Tanzania

Cited by 23 publications

References 35 publications

Impact of HIV on inpatient mortality and complications in stroke in Thailand: a National Database Study

Impact of HIV on inpatient mortality and complications in stroke in Thailand: a National Database Study

Recent advances in HIV-associated cardiovascular diseases in Africa

Analysis of the demographic characteristics and clinical profile of acute ischemic strokes admitted to the emergency centre in the Somalia population

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