The Prevalence of Diagnosed Systemic Lupus Erythematosus in Whites and Indian Asian Immigrants in Leicester City, Uk

Samanta, A.; Roy, Sasmit; Feehally, John; Dpm., Symmons

doi:10.1093/rheumatology/31.10.679

Cited by 62 publications

(49 citation statements)

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“…In one population prevalence study of SLE in North India, a point prevalence of 3.2 per 100,000 was observed [13]. Samanta, et al [14] studied the prevalence of SLE in Whites and Indian immigrants in the UK, and found that lupus was 3 times more common in Indians than in whites, among both males and females. Another study from Eastern India found that 3.9% of all children presenting to a pediatric rheumatology clinic had SLE [15].…”

Section: Epidemiologymentioning

confidence: 99%

Juvenile systemic lupus erythematosus: Review of clinical features and management

2011

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Section: Epidemiologymentioning

confidence: 99%

Juvenile systemic lupus erythematosus: Review of clinical features and management

2011

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“…10 However, studies in the UK have shown a prevalence of SLE about three times higher in Asian Indians residing there as compared with the white population. 11 This provides a timely alarm, as lifestyles and other environmental factors in India are at a stage of rapid transition, coming closer to those of western people.…”

Section: Introductionmentioning

confidence: 99%

Cytokine imbalance in systemic lupus erythematosus: a study on northern Indian subjects

Arora

Verma

Marwah

et al. 2012

Lupus

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This study showed a distinct profile of cytokine imbalance in patients with SLE from the northern plains of India. The levels, ratios and correlations of cytokines in patients suggested significant deviation from normal. Correlations of cytokines with SLEDAI scores indicated that TNF-α contributes significantly to the pathological manifestations of SLE in patients from the region. A detailed study is warranted.

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“…Systemic lupus erythematosus (SLE) is an autoimmune systemic rheumatic disease that occurs predominantly in women, especially those of African descent (1)(2)(3)(4)(5)(6). Twin studies have suggested that heritability accounts for 30-40% of the overall susceptibility to SLE (7); other "nongenetic" or environmental factors may also be involved in SLE etiology.…”

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confidence: 99%

Effect of glutathione S‐TRANSFERASE polymorphisms and proximity to hazardous waste sites on time to systemic lupus erythematosus diagnosis: Results from the roxbury lupus project

Karlson¹,

Watts²,

Signorovitch³

et al. 2007

Arthritis & Rheumatism

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Objective. The high prevalence of systemic lupus erythematosus (SLE) among African American women may be due to environmental exposures, genetic factors, or a combination of factors. Our goal was to assess association of residential proximity to hazardous waste sites and genetic variation in 3 glutathione Stransferase (GST) genes (GSTM1, GSTT1, and GSTP1) with age at diagnosis of SLE.Methods. Residential histories were obtained by interviewing 93 SLE patients from 3 predominantly African American neighborhoods in Boston. Residential addresses and locations of 416 hazardous waste sites in the study area were geocoded using ArcView software. Time-varying Cox models were used to study the effect of residential proximity to hazardous sites, GST genotype, and interaction between genotype and exposure in determining age at diagnosis.Results. The prevalence of SLE among African American women in these neighborhoods was 3.56 SLE cases per 1,000. Homozygosity for GSTM1-null and GSTP1 Ile105Val in combination was associated with earlier SLE diagnosis (P ‫؍‬ 0.03), but there was no association with proximity to 416 hazardous sites. Available data on specific site contaminants suggested that, at a subset of 67 sites, there was higher potential risk for exposure to volatile organic compounds (P < 0.05 with Bonferroni correction). GST genotypes had a significant interaction with proximity (P ‫؍‬ 0.03) in analyses limited to these sites.Conclusion. There was no independent association between residential proximity to hazardous waste sites and the risk of earlier SLE diagnosis in this urban population. However, analysis of a limited number of sites indicated that the risk of earlier SLE associated with proximity to hazardous sites might be modulated by GST polymorphisms.

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The Prevalence of Diagnosed Systemic Lupus Erythematosus in Whites and Indian Asian Immigrants in Leicester City, Uk

Cited by 62 publications

References 0 publications

Juvenile systemic lupus erythematosus: Review of clinical features and management

Juvenile systemic lupus erythematosus: Review of clinical features and management

Cytokine imbalance in systemic lupus erythematosus: a study on northern Indian subjects

Effect of glutathione S‐TRANSFERASE polymorphisms and proximity to hazardous waste sites on time to systemic lupus erythematosus diagnosis: Results from the roxbury lupus project

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