The prevalence of corporate funding in adult lower extremity research and its correlation with reported results

Inconsistencies Between Physician-Reported Disclosures at the AAOS Annual Meeting and Industry-Reported Financial Disclosures in the Open Payments Database

“…Physician-industry relationships can create a risk of bias in research study designs, experimental technique, and result interpretation and may affect treatment decisions in patient care [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] . However, physicians are in the best position to provide valuable innovations in design and safety that are mutually beneficial for patients, physicians, and industry 1 .…”

Industry and evidence-based medicine: Believable or conflicted? A systematic review of the surgical literature

“…Six of 8 studied the orthopedic literature, 4,15,16,18,19,21 1 the spine literature, 20 and 1 the combined literature from the disciplines of orthopedic surgery, neurosurgery, general surgery and plastic surgery. 17 Our systematic review demonstrated that authors'/ investigators' conflict of interest owing to financial affiliation with industry associated with their academic research was well documented in the surgical literature.…”

“…17 Our systematic review demonstrated that authors'/ investigators' conflict of interest owing to financial affiliation with industry associated with their academic research was well documented in the surgical literature. 4,12,[15][16][17][18][19][20][21] Although specific to orthopedic research, Zuckerman and colleagues 4 demonstrated that author self-reported conflict of interest involving research presented at a national annual meeting in the United States had substantially increased from 10% in 1985 to 32% in 2002 (p < 0.001).…”

“…[15][16][17][18]20,21 Bhandari and colleagues 17 found that, although not statistically significant, the odds ratio of a proindustry conclusion was 5 times greater in a surgical trial than in an industry-sponsored drug trial.…”

Role of Technology Assessment in Orthopaedics

“…One documented source of bias is manufacturer funding. In orthopaedics, published commercially funded studies tend to report a greater number of positive outcomes and larger positive effects than independently funded studies [14,28]. The best assessments examine only the Methods section of an article to determine whether the results are valid and, if they are valid, the Results section.…”