The prevalence and characteristics of Helicobacter pylori-associated gastritis in dyspeptic patients in Eastern Croatia, determined by immunohistochemistry

Brkić, Nikolina; Terzić, Velimir; Švagelj, Marija; Cvrković, Mirta; Brkić, Hrvoje; Švagelj, Dražen

doi:10.18054/pb.v119i1.4219

Cited by 4 publications

(2 citation statements)

References 17 publications

(22 reference statements)

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“…Out of the 53 studies that reported the prevalence of GIM, 12 studies reported the histological subtype 20 , 25 , 32 , 36 – 44 , 7 studies reported the extent of GIM 20 , 22 , 36 , 40 , 45 – 49 , and only 3 reported the OLGIM stage 48 , 50 , 51 . Additionally, 3 studies reported the association of dietary habits with finding GIM.…”

Section: Resultsmentioning

confidence: 99%

Advancing the Science in Gastric Pre-Neoplasia: Study Design Considerations

et al. 2020

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Section: Resultsmentioning

confidence: 99%

Advancing the Science in Gastric Pre-Neoplasia: Study Design Considerations

et al. 2020

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“…The current prevalence of active H. pylori infection cannot be assessed using serological methods because antibodies to H. pylori remain present even after the infection has been cured. In a study conducted on histological preparations of the gastric mucosa where H. pylori was detected using an immunohistochemical-specific stain, the frequency of H. pylori was 41.0% (in samples from 871 patients in Eastern Croatia) [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Pathohistological Changes in the Gastric Mucosa in Correlation with the Immunohistochemically Detected Spiral and Coccoid Forms of Helicobacter pylori

Brkić,

Švagelj,

Omazić

2024

Microorganisms

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Background: The coccoid form of Helicobacter pylori (H. pylori) is resistant to antibiotics. There are only a few studies that have analyzed the frequency of coccoid H. pylori in patients with gastritis. The aim of this work was to examine the correlation between the H. pylori form and the pathohistological characteristics of the stomach in patients with gastritis. Materials and methods: This research was cross-sectional and focused on the gastric mucosa samples of 397 patients from one general hospital in Croatia. Two independent pathologists analyzed the samples regarding the pathohistological characteristics and the form of H. pylori. Results: There was a statistically significant difference in the gender of patients with H. pylori gastritis. Only the coccoid form of H. pylori was present in 9.6% of patients. There was a statistically significant difference in the frequency of a certain form of the bacterium depending on its localization in the stomach. The intensity of the bacterium was low in the samples where only the coccoid or spiral form was described. In cases of infection in the antrum, premalignant lesions and the coccoid form of H. pylori were more often present. Conclusion: In the diagnosis of H. pylori infection, the determination of the form of the bacterium via immunohistochemistry should be included to increase the rate of eradication therapy and reduce the incidence of gastric malignancy.

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