The Presence of Simian-Virus 40 Sequences in Mesothelioma and Mesothelial Cells Is Associated with High Levels of Vascular Endothelial Growth Factor

Cacciotti, Paola; Strizzi, Luigi; Vianale, Giovina; Iaccheri, Laura; Libener, Roberta; Porta, Camillo; Tognon, Mauro; Gaudino, Giovanni; Mutti, Luciano

doi:10.1165/ajrcmb.26.2.4673

Cited by 66 publications

(35 citation statements)

References 25 publications

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“…We next stimulated HMC and SV40-negative MMB cells with HGF and VEGF, which have been reported to be induced by SV40 in malignant mesothelioma cells (12,15,20). These growth factors elicited Akt and Erk1/2 activities in HMC and SV40-negative MMB cells (Fig.…”

Section: Resultsmentioning

confidence: 90%

“…Interestingly, microarray analysis revealed that expression of Met, among other genes, is associated with asbestos exposure in mesothelial cells (13) and several other growth factors are released by SV40-positive HMC and malignant mesothelioma cells, including insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF; refs. 14,15).…”

Section: Introductionmentioning

confidence: 99%

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SV40-Dependent AKT Activity Drives Mesothelial Cell Transformation after Asbestos Exposure

et al. 2005

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Human malignant mesothelioma is an aggressive cancer generally associated with exposure to asbestos, although SV40 virus has been involved as a possible cofactor by a number of studies. Asbestos fibers induce cytotoxicity in human mesothelial cells (HMC), although cell survival activated by key signaling pathways may promote transformation. We and others previously reported that SV40 large T antigen induces autocrine loops in HMC and malignant mesothelioma cells, leading to activation of growth factor receptors. Now we show that SV40 induces cell survival via Akt activation in malignant mesothelioma and HMC cells exposed to asbestos. Consequently, prolonged exposure to asbestos fibers progressively induces transformation of SV40-positive HMC. As a model of SV40/asbestos cocarcinogenesis, we propose that malignant mesothelioma originates from a subpopulation of transformed stem cells and that Akt signaling is a novel therapeutic target to overcome malignant mesothelioma resistance to conventional therapies. (Cancer Res 2005; 65(12): 5256-62)

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Section: Resultsmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

SV40-Dependent AKT Activity Drives Mesothelial Cell Transformation after Asbestos Exposure

et al. 2005

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“…This effect may represent an important oncogenic mechanism and, once chromosomal alterations are fixed in the host cells, viral sequences may be dispensable for the maintenance of transformation and may be lost by the neoplastic tissues. It is possible therefore that, while continuous expression of BKV Tag is necessary for maintenance of BKV transformation in rodent cells, in human cells the transformed phenotype is maintained by mechanisms Tag induces production and release of hepatocyte growth factor and vascular endothelial growth factor (Cacciotti et al, 2001(Cacciotti et al, , 2002Catalano et al, 2002). The role of Tag in these functions was demonstrated by reversion of the neoplastic phenotype of mesothelioma cell lines after transfection and expression of an antisense SV40 Tag RNA (Waheed et al, 1999).…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Oncogenic transformation by BK virus and association with human tumors

et al. 2003

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BK virus (BKV), a human polyomavirus closely related to JC virus and Simian Virus 40, is ubiquitous in human populations worldwide. After primary infection, BKV establishes a lifelong latent infection in many organs. BKV transforms rodent cells to the neoplastic phenotype and is highly oncogenic in rodents. This review considers the oncogenic potential of BKV in humans and its possible involvement in human tumors. BKV sequences and T antigen (Tag) are detected in several types of human neoplasms, although the viral load is generally low, with less than one copy of the viral genome per cell. The possible causative role of BKV in human oncogenesis rests on the ability of BKV Tag to inactivate the functions of tumor suppressor proteins p53 and pRB family as well as on its ability to induce chromosomal aberrations in human cells. A 'hit and run' mechanism and secretion of paracrine growth factors by BKV Tag-positive cells, recruiting into proliferation neighboring and distant cells, are discussed as possible BKV pathogenic elements in human oncogenesis.

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“…open pleural biopsy (VATS, mini-thoracotomy) or not. Among these biomarkers, insulin growth factor, hepatocyte growth factor and Simian Virus-40 have been proven to play an important role in the development and progression of malignant mesothelioma [7][8][9]. Likewise, a recent study has shown that plasma N/CD-13 activity had a strong correlation with tumor load in malignant pleural diseases [10].…”

Section: Discussionmentioning

confidence: 99%

The diagnostic significance and the assessment of the value of vascular endothelial growth factor as a marker for success of chemical pleurodesis in malignant pleural effusion

Kılıç¹,

Fındıkçıoğlu²,

Alver³

et al. 2011

JBiSE

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Differential diagnosis of pleural effusion is an important issue, since the treatment modalities and prognosis strictly depend on early and correct diagnosis of the underlying etiology. We assessed the efficacy of vascular endothelial growth factor (VEGF) in the differential diagnosis of patients with malignant and non-malignant pleural diseases. And also is assessed of the VEGF as a marker for success of chemical pleurodesis in malignant pleural effusion. Pleural effusions of 40 patients with a mean age of 55 (range, 26 to 78 years) were examined. A total of 20 patients had malignant pleural effusion; malignant meso-thelioma (n = 7), lung cancer (n = 5) and metastatic malignancies (n = 8). Twenty patients had benign pleural effusion; fibrinous pleuritis (n = 6), tubercu-losis (n = 3) empyema (n = 5), congestive heart failure (n = 3), and acute pancreatitis (n = 3). Definitive di-agnosis was obtained in all cases with blind or open pleural biopsy, and cytological examination. VEGF levels were determined by enzyme-linked immu-nosorbent assay. The VEGF level of pleural effusion was comparably higher in the malignant group. The mean level of VEGF in patients with malignant pleu-ral effusions (21.7 ± 1.8 ng/ml) was significantly (P < 0.001) higher than that of (13.2 ± 1.5 ng/ml) non-malignant effusions. No significant difference was found regarding the VEGF levels and histological types in malignant pleural effusions. Negative correlation was observed between success rate of pleurodesis and VEGF level of pleural effusion (p = 0.015). The measurement of VEGF levels in pleural effusion may be useful to differentiate malignant from nonmalignant pleural effusions. VEGF level may also be an important prognostic marker for ef-fective treatment of the patients who had malignant pleural effusions with pleurodesis. It is important issue in here whether VEGF could be useful in prog-nostication of outcome of chemical pleurodesis or not.

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The Presence of Simian-Virus 40 Sequences in Mesothelioma and Mesothelial Cells Is Associated with High Levels of Vascular Endothelial Growth Factor

Cited by 66 publications

References 25 publications

SV40-Dependent AKT Activity Drives Mesothelial Cell Transformation after Asbestos Exposure

SV40-Dependent AKT Activity Drives Mesothelial Cell Transformation after Asbestos Exposure

Oncogenic transformation by BK virus and association with human tumors

The diagnostic significance and the assessment of the value of vascular endothelial growth factor as a marker for success of chemical pleurodesis in malignant pleural effusion

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