The presence of chronic inflammation in positive prostate biopsy is associated with upgrading in radical prostatectomy

Güner, Ekrem; Danacıoğlu, Yavuz Onur; Arikan, Yusuf; Şeker, Kamil Gökhan; Polat, Salih; Baytekin, Halil Fırat; Şimşek, Abdülmuttalip

doi:10.4081/aiua.2021.3.280

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…Given the strong prognostic power of biopsy GG in predicting clinical course and treatment efficacy in almost all stages of PCa, knowledge of preoperative NLR would add information to improve clinical decision making [ 36 ]. Guner E et al reported that the presence or absence of findings of chronic prostatitis on prostate biopsy is associated with the upgrading of surgical specimens [ 37 ]. This also supports the hypothesis that inflammation is associated with prostate cancer upgrading [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…Guner E et al reported that the presence or absence of findings of chronic prostatitis on prostate biopsy is associated with the upgrading of surgical specimens [ 37 ]. This also supports the hypothesis that inflammation is associated with prostate cancer upgrading [ 37 ]. In this study, the direct causal relationship between GG upgrading for RP specimens and the NLR remains unclear.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Predictors of Grade Group Upgrading for Radical Prostatectomy Specimens Compared to Those of Preoperative Needle Biopsy Specimens

et al. 2022

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Background: Decision-making and selection of treatment modalities for newly diagnosed prostate cancer (PCa) are often determined by risk stratification using grade group (GG), prostate-specific antigen (PSA), and clinical stage. The discrepancies between needle biopsy (NB) and radical prostatectomy (RP) specimens often occur because of the sampling errors in NB or multifocal features of PCa. Thus, we aimed to estimate the preoperative clinical factors for predicting GG upgrading after robot-assisted RP (RARP). Methods: In this retrospective study, we reviewed the clinical and pathological records of patients who underwent RARP at Gifu University Hospital. We focused on patients with organ-confined PCa who had not received neoadjuvant therapy prior to RARP. The primary endpoint was identified as the predictive factor of GG upgrading for RARP specimens compared to those of NB specimens. Results: Eighty-one patients were included in this study. The enrolled patients were divided into two groups: those who had GG upgrading for RARP specimens (the NB upgrade group) or those who did not have GG upgrading (the no upgrade group). The median age of all patients was 70 years, and the median body mass index (BMI) was 22.9 kg/m2. The median neutrophil count was 3720/μL, lymphocyte count was 1543/μL, and neutrophil-to-lymphocyte ratio (NLR) was 2.24. In univariate analysis, BMI, PSA, neutrophil count, and NLR were significantly associated with GG upgrading in RARP specimens compared to NB specimens. BMI and NLR were identified as strong predictive factors for GG upgrading in RARP specimens in the multivariate analysis. Conclusions: Although this study’s small number of enrolled patients was a vital weakness, BMI and NLR might have been significantly correlated with GG upgrading for RP specimens compared with NB specimens. Therefore, BMI and NLR may have potential benefits for newly diagnosed patients with PCa in terms of decision-making and the selection of treatment modalities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical Predictors of Grade Group Upgrading for Radical Prostatectomy Specimens Compared to Those of Preoperative Needle Biopsy Specimens

et al. 2022

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“…Infections such as bacterial prostatitis frequently linked to E. coli or other species of Enterobacteriaceae are identified as the leading causes of prostate inflammation [ 21 ]. In this context, various epidemiological studies have linked prostatitis with prostate cancer risk [ 22 ].…”

Section: Microbiome Inflammation and Prostate Cancermentioning

confidence: 99%

Microbiome and Prostate Cancer: A Novel Target for Prevention and Treatment

Kuštrimović

Bombelli

Baci

et al. 2023

IJMS

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Growing evidence of the microbiome’s role in human health and disease has emerged since the creation of the Human Microbiome Project. Recent studies suggest that alterations in microbiota composition (dysbiosis) may play an essential role in the occurrence, development, and prognosis of prostate cancer (PCa), which remains the second most frequent male malignancy worldwide. Current advances in biological technologies, such as high-throughput sequencing, transcriptomics, and metabolomics, have enabled research on the gut, urinary, and intra-prostate microbiome signature and the correlation with local and systemic inflammation, host immunity response, and PCa progression. Several microbial species and their metabolites facilitate PCa insurgence through genotoxin-mediated mutagenesis or by driving tumor-promoting inflammation and dysfunctional immunosurveillance. However, the impact of the microbiome on PCa development, progression, and response to treatment is complex and needs to be fully understood. This review addresses the current knowledge on the host–microbe interaction and the risk of PCa, providing novel insights into the intraprostatic, gut, and urinary microbiome mechanisms leading to PCa carcinogenesis and treatment response. In this paper, we provide a detailed overview of diet changes, gut microbiome, and emerging therapeutic approaches related to the microbiome and PCa. Further investigation on the prostate-related microbiome and large-scale clinical trials testing the efficacy of microbiota modulation approaches may improve patient outcomes while fulfilling the literature gap of microbial–immune–cancer-cell mechanistic interactions.

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“…The presence of chronic prostatitis was identified to be an independent marker for Gleason score upgrade (GSU) by Guner et al The researchers compared two groups with and without GSU in terms of chronic prostatitis. The study showed that the presence of chronic prostatitis associated with PCa was higher in the patient cohort with GSU in contrast to the other group [ 23 ].…”

Section: The Prostate Microbiome and Chronic Inflammationmentioning

confidence: 99%

Prostate Infiltration by Treg and Th17 Cells as an Immune Response to Propionibacterium acnes Infection in the Course of Benign Prostatic Hyperplasia and Prostate Cancer

Radej

Szewc

Maciejewski

2022

IJMS

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Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) belong to the most frequent diseases in ageing men. It has been proposed that prostate chronic inflammation is a risk factor for the development of both BPH and PCa. However, potential stimuli that cause or maintain inflammation in the prostate gland are still poorly characterized. Bacterial infections seems to be one of the potential sources of prostatitis. Recent studies show that Propionibacterium acnes (P. acnes) is the most prevalent microorganism in the prostate gland and may be a predisposing factor for inflammation of prostatic tissue. It indicates that P. acnes may contribute to cancer development by enhancing proinflammatory responses, as well as by modifying the prostate extracellular environment. In this review, we discuss the potential role of P. acnes in the development of BPH and PCa and highlight the importance of regulatory T CD4(+)FoxP3(+) (Treg) and Th17 cells in response to P. acnes infection in the context of both prostate diseases.

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The presence of chronic inflammation in positive prostate biopsy is associated with upgrading in radical prostatectomy

Cited by 6 publications

References 30 publications

Clinical Predictors of Grade Group Upgrading for Radical Prostatectomy Specimens Compared to Those of Preoperative Needle Biopsy Specimens

Clinical Predictors of Grade Group Upgrading for Radical Prostatectomy Specimens Compared to Those of Preoperative Needle Biopsy Specimens

Microbiome and Prostate Cancer: A Novel Target for Prevention and Treatment

Prostate Infiltration by Treg and Th17 Cells as an Immune Response to Propionibacterium acnes Infection in the Course of Benign Prostatic Hyperplasia and Prostate Cancer

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