The potential role of prebiotics, probiotics, and synbiotics in adjuvant cancer therapy especially colorectal cancer

Alam, Z.; Shang, Xiaobing; Effat, Khansa; Kanwal, Freeha; He, Xiaoqin; Li, Yanye; Xu, Chunlan; Niu, Weining; War, Abdul Rouf; Zhang, Yong

doi:10.1111/jfbc.14302

Cited by 18 publications

(7 citation statements)

References 151 publications

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“…Data on how the gut and female reproductive tract microbiome may influence a person's risk for postoperative morbidity are limited. In a study by Tong et al, significant differences were noted between stool samples taken pre-operatively, postoperatively, and during chemotherapy [81] . Further, they appreciated that OC patients significantly increased in anaerobic species such as Bacteroides, Collinsella, and Blautia during chemotherapy [81] .…”

Section: Impact Of the Microbiome Upon Surgical Management And Postop...mentioning

confidence: 96%

The microbiome and ovarian cancer: insights, implications, and therapeutic opportunities

Mehra,

Chalif,

Mensah-Bonsu

et al. 2023

J Cancer Metastasis Treat

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Ovarian cancer is the leading cause of gynecologic cancer death in the United States. Most ovarian cancer patients are diagnosed with advanced-stage disease, which poses a challenge for early detection and effective treatment. At present, cytoreductive surgery and platinum-based chemotherapy are foundational for patients with newly diagnosed ovarian cancer, but unfortunately, most patients will recur and die of their disease. Therefore, there is a significant need to seek innovative, novel approaches for early detection and to overcome chemoresistance for ovarian cancer patients. The microbiome, comprising diverse microbial communities inhabiting various body sites, is vital in maintaining human health. Changes to the diversity and composition of the microbial communities impact the microbiota-host relationship and are linked to diseases, including cancer. The microbiome contributes to carcinogenesis through various mechanisms, including altered host immune response, modulation of DNA repair, upregulation of pro-inflammatory pathways, altered gene expression, and dysregulated estrogen metabolism. Translational and clinical studies have demonstrated that specific microbes contribute to ovarian cancer development and impact chemotherapy’s efficacy. The microbiome is malleable and can be altered through different approaches, including diet, exercise, medications, and fecal microbiota transplantation. This review provides an overview of the current literature regarding ovarian cancer and the microbiome of female reproductive and gastrointestinal tracts, focusing on mechanisms of carcinogenesis and options for modulating the microbiota for cancer prevention and treatment. Advancing our understanding of the complex relationship between the microbiome and ovarian cancer may provide a novel approach for prevention and therapeutic modulation in the future.

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Section: Impact Of the Microbiome Upon Surgical Management And Postop...mentioning

confidence: 96%

The microbiome and ovarian cancer: insights, implications, and therapeutic opportunities

Mehra,

Chalif,

Mensah-Bonsu

et al. 2023

J Cancer Metastasis Treat

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“…It is known that probiotic oral vaccines promote mucosal immunity that prevents enteric infections and could complement the standard therapy in the patient[ 143 ]. Microorganisms administration including probiotics and synbiotics (pharmaceutical preparation that contains probiotics and prebiotics that implies a synergy between both) are a potential resource for prophylaxis and therapy in CRC[ 138 , 144 ]. In addition, the luminal cocktail of microorganisms in the bowel can be modified not only by dietary approaches but also with the use of antibiotics or fecal microbiota transplantation (FMT)[ 145 , 146 ].…”

Section: Therapeutic Targeting Of Tme and The Gut Microbiota: A Key T...mentioning

confidence: 99%

How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells

Díaz¹,

Carriere²,

Gentili³

2023

World J Stem Cells

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Colorectal cancer (CRC) remains the third most prevalent cancer disease and involves a multi-step process in which intestinal cells acquire malignant characteristics. It is well established that the appearance of distal metastasis in CRC patients is the cause of a poor prognosis and treatment failure. Nevertheless, in the last decades, CRC aggressiveness and progression have been attributed to a specific cell population called CRC stem cells (CCSC) with features like tumor initiation capacity, self-renewal capacity, and acquired multidrug resistance. Emerging data highlight the concept of this cell subtype as a plastic entity that has a dynamic status and can be originated from different types of cells through genetic and epigenetic changes. These alterations are modulated by complex and dynamic crosstalk with environmental factors by paracrine signaling. It is known that in the tumor niche, different cell types, structures, and biomolecules coexist and interact with cancer cells favoring cancer growth and development. Together, these components constitute the tumor microenvironment (TME). Most recently, researchers have also deepened the influence of the complex variety of microorganisms that inhabit the intestinal mucosa, collectively known as gut microbiota, on CRC. Both TME and microorganisms participate in inflammatory processes that can drive the initiation and evolution of CRC. Since in the last decade, crucial advances have been made concerning to the synergistic interaction among the TME and gut microorganisms that condition the identity of CCSC, the data exposed in this review could provide valuable insights into the biology of CRC and the development of new targeted therapies.

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“…Combination therapies, which involve combining microbiome-targeting interventions with conventional cancer therapies, such as chemotherapy, radiotherapy, or immunotherapy, may enhance treatment efficacy by modulating the tumor stroma and improving the overall tumor microenvironment [ 102 ]. These combination strategies could help overcome therapy resistance and improve patient outcomes.…”

Section: The Gut Microbiome and Crc: Dysbiosis Tumor Stroma Modulatio...mentioning

confidence: 99%

Cellular and Molecular Mechanisms of the Tumor Stroma in Colorectal Cancer: Insights into Disease Progression and Therapeutic Targets

Shakhpazyan,

Mikhaleva,

Bedzhanyan

et al. 2023

Biomedicines

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Colorectal cancer (CRC) is a major health burden worldwide and is the third most common type of cancer. The early detection and diagnosis of CRC is critical to improve patient outcomes. This review explores the intricate interplay between the tumor microenvironment, stromal interactions, and the progression and metastasis of colorectal cancer. The review begins by assessing the gut microbiome’s influence on CRC development, emphasizing its association with gut-associated lymphoid tissue (GALT). The role of the Wnt signaling pathway in CRC tumor stroma is scrutinized, elucidating its impact on disease progression. Tumor budding, its effect on tumor stroma, and the implications for patient prognosis are investigated. The review also identifies conserved oncogenic signatures (COS) within CRC stroma and explores their potential as therapeutic targets. Lastly, the seed and soil hypothesis is employed to contextualize metastasis, accentuating the significance of both tumor cells and the surrounding stroma in metastatic propensity. This review highlights the intricate interdependence between CRC cells and their microenvironment, providing valuable insights into prospective therapeutic approaches targeting tumor–stroma interactions.

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The potential role of prebiotics, probiotics, and synbiotics in adjuvant cancer therapy especially colorectal cancer

Cited by 18 publications

References 151 publications

The microbiome and ovarian cancer: insights, implications, and therapeutic opportunities

The microbiome and ovarian cancer: insights, implications, and therapeutic opportunities

How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells

Cellular and Molecular Mechanisms of the Tumor Stroma in Colorectal Cancer: Insights into Disease Progression and Therapeutic Targets

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