The potential role of nutritional components in improving brain function among patients with Alzheimer’s disease: a meta-analysis of RCT studies

Abstract

Objectives: To find out the potential role of nutritional components in improving brain function among patients with Alzheimer's disease)AD(. Methods: The correlation between nutrition and cerebral function in cases of AD has been the focus of 19 prospective randomised controlled trials)RCTs(Systematic Review with a combined research sample of 2297 patients. These RCTs are subject to systematic review and meta-analysis in the current paper. Results: Findings showed that chain-free secondary saturated fatty acids)SFA(and trans fatty acids)TFA(occurred in higher concentrations in AD patients' brains than in controls. Furthermore, neuroinflammation was caused by remodelling of the lipid membrane and AD patients' cognitive function was impacted by alterations in tyrosine, tryptophan, purine, and tocopherol pathway metabolomics. Moreover, in cases of mild-to-moderate AD, reduction in functionality was induced by administration of alpha-tocopherol for more than 12 months. Consumption of Souvenaid helps in synaptic synthesis, which enhances functional connectivity. Furthermore, consumption of the B vitamins folate, cobalamin and pyridoxine at dosages of 0.8 mg, 0.5 mg and 20 mg per day, respectively, over a period of one year resulted in lower plasma tHcy levels and brain atrophy. Conclusion: Chain-free SFA and TFA occur in greater amounts in the brains of individuals with AD than in those without AD.

Targeted Metabolic Profiling of Urine Highlights a Potential Biomarker Panel for the Diagnosis of Alzheimer’s Disease and Mild Cognitive Impairment: A Pilot Study

“…Although controversial, vitamin B6 has been implicated as one of the protective factors against cognitive decline and AD [39]. Consumption of the vitamins pyridoxine, folate, and cobalamin at dosages of 20, 0.8, and 0.5 mg per day, respectively, for at least one year has been suggested to decrease brain atrophy and plasma total homocysteine levels, which have direct neurotoxic effects and are linked to brain atrophy in AD [40].…”

The development of a dietary nutrient density educational tool and the investigation of its acceptance by Chinese residents from Henan province

“…Consumers were advised to seek out nutrient-dense foods to meet nutrient requirements without exceeding daily energy needs, which is a strategy to improve their diet quality [11] . Not limited to individual foods only, the NRF algorithm can be applied to food groups, meals, menus, and total diets, which describes the science that helps consumers make informed decisions about their food choices-both inside and outside the store [19] .…”

“…Nutrient-dense foods have been described as providing substantial amounts of nutrients for relatively few calories or offering fewer calories than nutrients [10] . Helping consumers select nutrient-dense foods is a strategy to improve their diet quality [11] . Nutrient-rich foods (NRF) index was a valid tool to assess the nutrient density of individual foods and also to assess the total diet [4,12,13] .…”

Dietary fat, telomere length and cognitive function: unravelling the complex relations

“…Overall, the findings suggest that a high intake of saturated fats and trans fats, mainly found in ultra-processed foods, may have detrimental effects on cognitive function. These effects include hindering the attention and overall detectability, reducing cerebral perfusion, increasing the risk of AD by altering cerebrospinal fluid AD biomarkers and increasing the levels of saturated fats and trans fats in the brain of AD patients [22–24]. Conversely, healthy fats, such as n-3 PUFAs found in fatty fish, nuts, and dietary patterns like MD, ketogenic diet (KD) and MIND diet, have been associated with improved cognitive performance, better quality of life and a reduced risk of cognitive decline [22,23,25–28].…”