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“…In addition, rodent studies indicate that chronic use of metformin prevents the adverse effects of aging and increases life expectancy [13,14], and data from a meta-analysis confirms decreased risk of Parkinson's disease in combination with sulfonylurea derivatives [15]. As it was previously demonstrated, the effects of metformin occur are attributed to the AMP-activated protein kinase (AMPK) activation and phosphorylation followed by increased peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) expression [1,16] of muscle coordination and activity [17]. In vitro models show that metformin is able to stop the apoptotic process via AMPK pathway [18], being a possible therapeutic target in neurodegenerative diseases [7].…”
Section: Introductionmentioning
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“…In addition, rodent studies indicate that chronic use of metformin prevents the adverse effects of aging and increases life expectancy [13,14], and data from a meta-analysis confirms decreased risk of Parkinson's disease in combination with sulfonylurea derivatives [15]. As it was previously demonstrated, the effects of metformin occur are attributed to the AMP-activated protein kinase (AMPK) activation and phosphorylation followed by increased peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) expression [1,16] of muscle coordination and activity [17]. In vitro models show that metformin is able to stop the apoptotic process via AMPK pathway [18], being a possible therapeutic target in neurodegenerative diseases [7].…”
Section: Introductionmentioning
“…However, treatment with AMPK activators could attenuate these behavioral and molecular changes in the pathophysiological profile of metabolic dysfunction (Wang et al 2018 ). Various studies have shown that treatment with metformin is effective in neurological diseases, including high MPTP and increased BDNF (Patil et al 2014 , Lu et al 2016 ), Parkinson’s disease (Choi et al 2010 ; Arbeláez-Quintero and Palacios 2017 ; Lu et al 2020 , Paudel et al 2020 ), epilepsy (H S, Paudel et al 2019 , Demaré et al 2021 ; Sanz et al 2021 , Salvati et al 2022 ), traumatic brain injury (Tao et al 2018 ; Taheri et al 2019 ; Fan et al 2020 ; Rahimi et al 2020 ), neuroprotection of the heart (Zhu et al 2018 , Benjanuwattra et al 2020 , Leech et al 2020 ), and preconditioning in ischemic brain injury (Wang et al 2021a , b , c ). Various studies have shown that BDNF can affect the structure of the anal sphincter (Singh and Rattan 2021 , Singh, Singh et al 2021 ).…”
Section: Metformin and Therapeutic Goalsmentioning
“…Mtf also finds its use in reproductive biology to treat cases of polycystic ovary syndrome (PCOS) and obese male fertility as the pathology of the disease is often related with insulin resistance [ 9 , 10 ]. A recent study reported that in the brains of Parkinson’s disease (PD) patients, Mtf causes a reduction in the neuronal damage via neuroprotection and oxidative stress inhibition and inflammatory responses, furnishing a novel PD strategy [ 11 ]. Another piece of literature established that long-term Mtf therapy (>2 years) results in the lower incidences of NDs in elderly T2DM patients [ 12 ].…”
Section: Introductionmentioning