2015
DOI: 10.1080/15384047.2015.1056414
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Abstract: Cellular resistance in advanced gastric cancer (GC) might be related to function of multidrug resistance (MDR) proteins. The adaptor protein NHERF1 (Na C /H C exchanger regulatory factor) is an important player in cancer progression for a number of solid malignancies, even if its role to develop drug resistance remains uncertain. Herein, we aimed to analyze the potential association between NHERF1 expression and P-gp, sorcin and HIF-1a MDR-related proteins in advanced GC patients treated with epirubicin/oxalip… Show more

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Cited by 13 publications
(9 citation statements)
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References 44 publications
(56 reference statements)
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“…SORCIN, soluble resistance‐related calcium‐binding protein, is a penta‐EF hand Ca 2+ binding protein implicated in regulation of intracellular calcium homeostasis (Colotti et al, ). SORCIN is highly expressed in some mammalian normal tissues such as heart (Suarez et al, ) and brain (Kim, Lee, Kim, Kwon, & Chun, ), and overexpresses in various cancer multidrug‐resistance cells (Mangia et al, ; Meyers, Schneider, Spengler, Chang, & Biedler, ). SORCIN participates in the formation of drug resistance in tumoral cells (Gao, Li, Liu, Gao, & Zhao, ).…”
Section: Introductionmentioning
confidence: 99%
“…SORCIN, soluble resistance‐related calcium‐binding protein, is a penta‐EF hand Ca 2+ binding protein implicated in regulation of intracellular calcium homeostasis (Colotti et al, ). SORCIN is highly expressed in some mammalian normal tissues such as heart (Suarez et al, ) and brain (Kim, Lee, Kim, Kwon, & Chun, ), and overexpresses in various cancer multidrug‐resistance cells (Mangia et al, ; Meyers, Schneider, Spengler, Chang, & Biedler, ). SORCIN participates in the formation of drug resistance in tumoral cells (Gao, Li, Liu, Gao, & Zhao, ).…”
Section: Introductionmentioning
confidence: 99%
“…The NHERF1 protein is physiologically expressed at the apical membrane of polarized epithelial cells and it is a major component of signalling complexes [ 7 , 8 ]. Increased NHERF1 expression has been reported in a variety of human malignant tissues [ 3 , 9 - 14 ]. The most extensive analyses of the role of NHERF1 in cancer development have been performed for BC [ 7 , 15 - 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…40 The primary antibody was mouse monoclonal anti-HIPK2 (ab57328; Abcam; 1:300 dilution). Human gastric tissues were used as positive control and the primary antibody was omitted and replaced by PBS pH7.6 for negative control.…”
Section: Hif1a Mdr1 and Hipk2 Expressionmentioning
confidence: 99%