volume 274, issue 1-2, P35-40 2004
DOI: 10.1016/j.ijpharm.2004.01.018
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Abstract: The purpose of this study was to explore whether it is possible to use hyper differential scanning calorimetry (HDSC) to detect and quantify low levels of amorphous content in samples that are mostly crystalline. HDSC uses scan rates that are much faster than conventional DSC, and consequently results in greater sensitivity. It was found that with every increase in scan rate it became easier to detect the glass transition (Tg) response. Scanning at 500 degrees C/min was possible and this gave such great sensit…

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