The potential neuroprotective role of mesenchymal stem cell-derived exosomes in cerebellar cortex lipopolysaccharide-induced neuroinflammation in rats: a histological and immunohistochemical study

El-Mahalaway, Abeer M.; El-Azab, Nahla El-Eraky

doi:10.1080/01913123.2020.1726547

Cited by 7 publications

(7 citation statements)

References 34 publications

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“…ASCs were suggested to inhibit the activation of glia and microglial and reduce the expression levels of pro‐inflammatory cytokines TNF‐α, IL‐1β and IL‐6 in the cerebellum. 97 , 98 , 99 …”

Section: Discussionmentioning

confidence: 99%

“…ASCs were suggested to inhibit the activation of glia and microglial and reduce the expression levels of pro-inflammatory cytokines TNFα, IL-1β and IL-6 in the cerebellum. 97,98,99 In conclusion, Monosodium glutamate (MSG) is the most commonly used food additive. While having huge benefits to the food industry, the ubiquitous use of MSG may have negative consequences for public health.…”

Section: Discussionmentioning

confidence: 99%

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Therapeutic role of adipose tissue–derived stem cells versus microvesicles in a rat model of cerebellar injury

Mazen

Abdel-Fattah

Desoky

et al. 2021

J Cellular Molecular Medi

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Monosodium glutamate (MSG) is a salt originally derived from herb and commonly marketed as a flavour enhancer. 1 It becomes extensively used in canned food, frozen entrees, crackers, processed meats and dietary supplements. It is also found in soaps, cosmetics, infant formula and vaccines. 2 MSG dissociates in solution to glutamate and sodium ions. 1 Glutamate is the foremost excitatory neurotransmitter in the body.Numerous transporters and receptors for glutamate are found in the

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Therapeutic role of adipose tissue–derived stem cells versus microvesicles in a rat model of cerebellar injury

Mazen

Abdel-Fattah

Desoky

et al. 2021

J Cellular Molecular Medi

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“…For example, cell death, a common manifestation of neurodegenerative diseases, was reduced by exosome treatment in models of stroke, TBI, perinatal brain injury, and SCI [ 32 , 38 , 40 , 41 , 42 , 43 ]. In addition, exosome therapy was shown to contribute to neuronal preservation and to have neuroprotective and regenerative effects on neurons, synapses, and myelin sheaths, as demonstrated in models of neuroinflammation, Alzheimer’s, stroke, and SCI [ 37 , 39 , 42 , 44 , 45 , 46 , 47 , 48 ]. The ability of exosomes to prevent scar tissue formation also contributed to regeneration in SCI [ 39 ].…”

Section: Clinical Outcomes Following Msc-derived Exosome Treatmentmentioning

confidence: 99%

“…Besides these four major mechanisms, MSC-derived exosome treatment may also provide protection from insults by reducing oxidative stress [ 36 , 44 ] and restoring the integrity of the BBB [ 40 ]. Since the etiology of neurodegenerative diseases is complex, the mechanisms by which recovery can occur are complex and intertwined.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Promising Opportunities for Treating Neurodegenerative Diseases with Mesenchymal Stem Cell-Derived Exosomes

Guy

Offen

2020

Biomolecules

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Neurodegenerative disease refers to any pathological condition in which there is a progressive decline in neuronal function resulting from brain atrophy. Despite the immense efforts invested over recent decades in developing treatments for neurodegenerative diseases, effective therapy for these conditions is still an unmet need. One of the promising options for promoting brain recovery and regeneration is mesenchymal stem cell (MSC) transplantation. The therapeutic effect of MSCs is thought to be mediated by their secretome, and specifically, by their exosomes. Research shows that MSC-derived exosomes retain some of the characteristics of their parent MSCs, such as immune system modulation, regulation of neurite outgrowth, promotion of angiogenesis, and the ability to repair damaged tissue. Here, we summarize the functional outcomes observed in animal models of neurodegenerative diseases following MSC-derived exosome treatment. We will examine the proposed mechanisms of action through which MSC-derived exosomes mediate their therapeutic effects and review advanced studies that attempt to enhance the improvement achieved using MSC-derived exosome treatment, with a view towards future clinical use.

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“…MSC exosomes triggered and stimulated the release of pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukins IL-1β and IL-6, by the activated astrocytes and microglia, causing neuronal cell degeneration and synaptic dysfunction. However, in addition to this paracrine pro-inflammatory activity, the exosomes exhibited a protective effect, predominantly on Purkinje neurons, as shown by a reduction in DNA damage and apoptosis [ 72 ].…”

Section: Evs In Developmental Pathology Of the Nervous Systemmentioning

confidence: 99%

Extracellular Vesicles in CNS Developmental Disorders

Gomes

Sangani

Fernandes

et al. 2020

IJMS

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The central nervous system (CNS) is the most complex structure in the body, consisting of multiple cell types with distinct morphology and function. Development of the neuronal circuit and its function rely on a continuous crosstalk between neurons and non-neural cells. It has been widely accepted that extracellular vesicles (EVs), mainly exosomes, are effective entities responsible for intercellular CNS communication. They contain membrane and cytoplasmic proteins, lipids, non-coding RNAs, microRNAs and mRNAs. Their cargo modulates gene and protein expression in recipient cells. Several lines of evidence indicate that EVs play a role in modifying signal transduction with subsequent physiological changes in neurogenesis, gliogenesis, synaptogenesis and network circuit formation and activity, as well as synaptic pruning and myelination. Several studies demonstrate that neural and non-neural EVs play an important role in physiological and pathological neurodevelopment. The present review discusses the role of EVs in various neurodevelopmental disorders and the prospects of using EVs as disease biomarkers and therapeutics.

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The potential neuroprotective role of mesenchymal stem cell-derived exosomes in cerebellar cortex lipopolysaccharide-induced neuroinflammation in rats: a histological and immunohistochemical study

Cited by 7 publications

References 34 publications

Therapeutic role of adipose tissue–derived stem cells versus microvesicles in a rat model of cerebellar injury

Therapeutic role of adipose tissue–derived stem cells versus microvesicles in a rat model of cerebellar injury

Promising Opportunities for Treating Neurodegenerative Diseases with Mesenchymal Stem Cell-Derived Exosomes

Extracellular Vesicles in CNS Developmental Disorders

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