The potential long-term impact of the COVID-19 outbreak on patients with non-communicable diseases in Europe: consequences for healthy ageing

Palmer, Katie; Monaco, Alessandro; Kivipelto, Miia; Onder, Graziano; Maggi, Stefania; Michel, Jean Pierre; Prieto, Rita; Sykara, Georgia; Donde, Shaantanu

doi:10.1007/s40520-020-01601-4

Cited by 290 publications

(331 citation statements)

References 29 publications

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“…However, our findings do not inform the predictive value of frailty for subsequent outcomes of COVID-19. They do, however, demonstrate that such individuals are generally at high risk of hospitalisation and requiring testing for COVID-19, and therefore risk minimization for older frail or multimorbid individuals remains highly appropriate [35].…”

Section: Discussionmentioning

confidence: 95%

COVID-19 and associations with frailty and multimorbidity: a prospective analysis of UK Biobank participants

et al. 2020

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Background Frailty and multimorbidity have been suggested as risk factors for severe COVID-19 disease. Aims We investigated, in the UK Biobank, whether frailty and multimorbidity were associated with risk of hospitalisation with COVID-19. Methods 502,640 participants aged 40–69 years at baseline (54–79 years at COVID-19 testing) were recruited across UK during 2006–10. A modified assessment of frailty using Fried’s classification was generated from baseline data. COVID-19 test results (England) were available for 16/03/2020–01/06/2020, mostly taken in hospital settings. Logistic regression was used to discern associations between frailty, multimorbidity and COVID-19 diagnoses, after adjusting for sex, age, BMI, ethnicity, education, smoking and number of comorbidity groupings, comparing COVID-19 positive, COVID-19 negative and non-tested groups. Results 4510 participants were tested for COVID-19 (positive = 1326, negative = 3184). 497,996 participants were not tested. Compared to the non-tested group, after adjustment, COVID-19 positive participants were more likely to be frail (OR = 1.4 [95%CI = 1.1, 1.8]), report slow walking speed (OR = 1.3 [1.1, 1.6]), report two or more falls in the past year (OR = 1.3 [1.0, 1.5]) and be multimorbid (≥ 4 comorbidity groupings vs 0–1: OR = 1.9 [1.5, 2.3]). However, similar strength of associations were apparent when comparing COVID-19 negative and non-tested groups. However, frailty and multimorbidity were not associated with COVID-19 diagnoses, when comparing COVID-19 positive and COVID-19 negative participants. Discussion and conclusions Frailty and multimorbidity do not appear to aid risk stratification, in terms of positive versus negative results of COVID-19 testing. Investigation of the prognostic value of these markers for adverse clinical sequelae following COVID-19 disease is urgently needed.

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Section: Discussionmentioning

confidence: 95%

COVID-19 and associations with frailty and multimorbidity: a prospective analysis of UK Biobank participants

et al. 2020

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“…Actions related to the improvement of the quality and validity of the information received by the population would certainly benefit also to the global state of mental health. Finally, the interventions deployed during and after the Covid-19 crisis would benefit from the use of cost-effective tools such as digital technologies [32], to deliver the above-mentioned components of the interventions in a timely, personalized, and remote manner.…”

Section: Resultsmentioning

confidence: 99%

Behavioral Changes During COVID-19 Confinement in France: A Web-Based Study

Rossinot¹,

Fantin

Venne

2020

Preprint

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(1) Background: A global pandemic due to COVID-19 emerged in November 2019 and hit France in early March 2020. It not only resulted in a loss of lives but also in very strict confinement measures. The objective of this study was to understand what the determinants of the change in participants’ behavior and mental state were during the confinement. (2) Methods: An online survey was launched on April 23rd, 2020, and closed on May 7th, 2020. The final sample included 1454 participants from 24 to 65 years old. Descriptive and multivariate analyses were then performed. (3) Results: 28.7% reported having a more balanced diet, against 17.1% with a less balanced diet. 22.7% of respondents reported an increased alcohol consumption, as opposed to only 12.2% declaring a decrease and 11.2% of respondents increased their tobacco consumption, while 6.3% decreased it. 50.6% of the participants reported being more depressed, stressed, or irritable since the beginning of the lockdown. Confinement had a negative effect on every behavior studied in this survey, except for nutrition. We also found that negative mental state changes were strongly associated with nutrition, sleep, physical activity, and alcohol consumption changes.

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“…Furthermore, physical activity and other healthy lifestyles worldwide were also affected by social distancing and quarantine restrictions (19). Home-isolation also tends to affect vitamin D levels by reducing the number of hours spent outdoors.…”

Section: Loneliness Social Isolation and Late-life Neuropsychiatricmentioning

confidence: 99%

Social Frailty in the COVID-19 Pandemic Era

et al. 2020

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Special attention and efforts to protect from or reduce health-related outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus triggering coronavirus disease 2019 (COVID-19), should be applied in susceptible populations, including frail older people. In particular, the early death cases occurred primarily in older people with a frailty status, possibly due to a weaker immune system fostering faster progression of the viral infection. Frailty is an age-related multidimensional clinical condition defined as a non-specific state of vulnerability, identifying older people at increased risk of falls, institutionalization, hospitalization, disability, dementia, and death. Among frailty phenotypes, social frailty has been least studied. It considers the role of socioeconomic context as a vulnerability status later in life. COVID-19 does not affect all populations equally, and social inequalities contribute to drive the spread of infections. It was known that the perception of social isolation, e.g., loneliness, affects mental and physical health, but the implicated molecular mechanisms, also related to the immune system, and its associated cognitive and health-related sequelae, are poorly understood. The increasing psychological distress derived by prolonged exposure to stress due to the lockdown scenario, and the reduced sources of support, contributed to making heavy demands on personal resources, i.e., self-efficacy and interpersonal variables. So, perceived loneliness may be a factor associated with psychological distress and an outcome in itself. In the COVID-19 pandemic era, a correct assessment of social frailty may be essential in terms of the prevention of late-life neuropsychiatric disorders.

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The potential long-term impact of the COVID-19 outbreak on patients with non-communicable diseases in Europe: consequences for healthy ageing

Cited by 290 publications

References 29 publications

COVID-19 and associations with frailty and multimorbidity: a prospective analysis of UK Biobank participants

COVID-19 and associations with frailty and multimorbidity: a prospective analysis of UK Biobank participants

Behavioral Changes During COVID-19 Confinement in France: A Web-Based Study

Social Frailty in the COVID-19 Pandemic Era

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