The Potential for Synovium-derived Stem Cells in Cartilage Repair

Kubosch, Eva Johanna; Lang, Gernot; Fürst, David; Kubosch, David; Izadpanah, Kaywan; Rolauffs, Bernd; Südkamp, Norbert P.; Schmal, Hagen

doi:10.2174/1574888x12666171002111026

Cited by 69 publications

(55 citation statements)

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“…Articular cartilage tissue presents limited cellularity and lacks a vascular system, leading to restrained healing capability (6,7). Actually, there is no available treatment to regenerate hyaline cartilage or modify disease progression (8).…”

Section: Introductionmentioning

confidence: 99%

“…Actually, there is no available treatment to regenerate hyaline cartilage or modify disease progression (8). Consequently, cartilage injuries are often related to pain and joint instability that may diminish or even cease the tissue's functionality (6,7). Thus, articular cartilage is at high risk of damage during initial trauma and, if left untreated, may results in lesions in the underlying subchondral bone, leading to biomechanics and homeostasis disturbances in the knee as a whole.…”

Section: Introductionmentioning

confidence: 99%

“…ACI is a two-step procedure that consists of healthy cartilage harvesting through arthroscopy followed by the expanded cell culture and, in a second step, cartilage defect filling (13)(14)(15). In spite of second and third ACI generations' versatility, those techniques use healthy cartilage tissue, "in vitro" related chondrocytes dedifferentiation and still fails to fully reproduce the hyaline characteristics of the original articular cartilage (6,13,(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

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Macrophage: A Potential Target on Cartilage Regeneration

et al. 2020

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Cartilage lesions and osteoarthritis (OA) presents an ever-increasing clinical and socioeconomic burden. Synovial inflammation and articular inflammatory environment are the key factor for chondrocytes apoptosis and hypertrophy, ectopic bone formation and OA progression. To effectively treat OA, it is critical to develop a drug that skews inflammation toward a pro-chondrogenic microenvironment. In this narrative and critical review, we aim to see the potential use of immune cells modulation or cell therapy as therapeutic alternatives to OA patients. Macrophages are immune cells that are present in synovial lining, with different roles depending on their subtypes. These cells can polarize to pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes, being the latter associated with wound-healing by the production of ARG-1 and pro-chondrogenic cytokines, such as IL-10, IL-1RA, and TGF-b. Emerging evidence reveals that macrophage shift can be determined by several stimuli, apart from the conventional in vitro IL-4, IL-13, and IL-10. Evidences show the potential of physical exercise to induce type 2 response, favoring M2 polarization. Moreover, macrophages in contact with oxLDL have effect on the production of anabolic mediators as TGF-b. In the same direction, type II collagen, that plays a critical role in development and maturation process of chondrocytes, can also induce M2 macrophages, increasing TGF-b. The mTOR pathway activation in macrophages was shown to be able to polarize macrophages in vitro, though further studies are required. The possibility to use mesenchymal stem cells (MSCs) in cartilage restoration have a more concrete literature, besides, MSCs also have the capability to induce M2 macrophages. In the other direction, M1 polarized macrophages inhibit the proliferation and viability of MSCs and impair their ability to immunosuppress the environment, preventing cartilage repair. Therefore, even though MSCs therapeutic researches advances, other sources of M2 polarization are attractive issues, and further studies will contribute to the possibility to manipulate this polarization and to use it as a therapeutic approach in OA patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Macrophage: A Potential Target on Cartilage Regeneration

et al. 2020

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“…They may prove to be the optimal cell source of MSCs as native nature to the joints. Kubosch et al [58] reported that S-MSCs play an important role in joint homeostasis and possibly in natural cartilage repair. However, most of their evidence was limited to preclinical studies [61].…”

Section: Synovium-derived Mesenchymal Stem Cellsmentioning

confidence: 99%

Current perspectives in stem cell therapies for osteoarthritis of the knee

Kim

2020

Yeungnam Univ J Med

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Mesenchymal stem cells (MSCs) are emerging as an attractive option for osteoarthritis (OA) of the knee joint, due to their marked disease-modifying ability and chondrogenic potential. MSCs can be isolated from various organ tissues, such as bone marrow, adipose tissue, synovium, umbilical cord blood, and articular cartilage with similar phenotypic characteristics but different proliferation and differentiation potentials. They can be differentiated into a variety of connective tissues such as bone, adipose tissue, cartilage, intervertebral discs, ligaments, and muscles. Although several studies have reported on the clinical efficacy of MSCs in knee OA, the results lack consistency. Furthermore, there is no consensus regarding the proper cell dosage and application method to achieve the optimal effect of stem cells. Therefore, the purpose of this study is to review the characteristics of various type of stem cells in knee OA, especially MSCs. Moreover, we summarize the clinical issues faced during the application of MSCs.

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“…4,5 Articular cartilage has limited potential for repair due to a lack of vascularity and limited cellularity. 6,7 As a consequence, cartilage injuries can result in chronic disability, 6,7 the development of osteoarthritis with significant physical limitations and decreased quality of life. 8 Among cell therapeutic solutions and regenerative techniques, there are two main examples: autologous chondrocyte implantation (ACI) and mesenchymal stem cells (MSCs).…”

Section: Introductionmentioning

confidence: 99%

Systematic Review of Human Dental Pulp Stem Cells for Cartilage Regeneration

Fernandes

SantAnna

Frisene

et al. 2020

Tissue Engineering Part B: Reviews

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Background: Symptomatic cartilage lesions and early osteoarthritis produce significant clinical and economic burdens. Cartilage repair can improve the symptoms and delay arthroplasty. The complete healing of damaged cartilage with the consistent reproduction of normal hyaline cartilage has not yet been achieved. The choice of harvesting site might influence the cells' abilities to modulate immunologic and inflammatory responses. Recently, dental pulp has been shown to contain a stem cell niche consisting of dental pulp stem cells (DPSCs) that maintain their self-renewal capacity due to the active environment in the dental pulp of deciduous teeth. Objective: The aim of this study was to critically review the current literature on the potential and limitations of the use of dental pulp-derived mesenchymal stem cells in cell-based therapies for cartilage regeneration. Methods: An electronic, customized search of scientific articles was conducted using the PubMed/MEDLINE and EMBASE databases from their inception to December 2018. The inclusion criteria were applied, and the articles that described the use of DPSC in cartilage treatment were selected for complete evaluation. The articles were classified according to the scaffold used, experimental model, chondrogenic differentiation features, defect location, cartilage evaluation, and results. After the application of the eligibility criteria, a total of nine studies were selected and fully analyzed. Results: A variety of animal models were used, including mice, rats, rabbits, and miniature pigs, to evaluate the quality and safety of human DPSCs in the repair of cartilage defects. Among the articles, two studies focused on preclinical models of cartilage tissue engineering. Five studies implanted DPSCs in other animal sites. Conclusion: The use of DPSCs is a potential new stem cell therapy for articular cartilage repair. The preclinical evidence discussed in this article provides a solid foundation for future clinical trials.

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The Potential for Synovium-derived Stem Cells in Cartilage Repair

Cited by 69 publications

References 0 publications

Macrophage: A Potential Target on Cartilage Regeneration

Macrophage: A Potential Target on Cartilage Regeneration

Current perspectives in stem cell therapies for osteoarthritis of the knee

Systematic Review of Human Dental Pulp Stem Cells for Cartilage Regeneration

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