The potential for improved outcome in patients with hepatic metastases from colon cancer: a population-based study

Radiofrequency Ablation vs. Resection for Hepatic Colorectal Metastasis: Therapeutically Equivalent?

“…1 While systemic chemotherapy can slow growth and even cause regression of hepatic metastases, long-term survival without local therapy is unlikely. Surgical resection of hepatic metastases continues to remain the optimal first-line treatment for hepatic colorectal metastases.…”

Selective Targeting of Antitumor Immune Responses with Engineered Live-Attenuated Listeria monocytogenes

“…number of nodules (8)(9)(10)(11)(12)(13)(14)(15)(16)(17), the GVAX group had 2 to 5 nodules, the LM-actA group had 6 to 7 nodules, and the combination therapy group had 0 to 1 nodule. There was a highly significant difference between the number of nodules seen in the combination group compared with the other groups (P < 0.001; Fig.…”

“…For example, the majority of patients with advanced colorectal cancer will have metastatic disease limited only to the liver during some period of their illness, and one third of patients dying of colorectal cancer have metastatic disease limited to the liver on autopsy (11). Less than 20% of these patients with isolated hepatic metastases will have disease resectable for potential cure (12). Of the patients who undergo complete resection, f30% to 40% of these patients will survive 5 years and half will be with evidence of disease.…”

Nonsurgical Approaches to Colorectal Cancer

“…This low rate of resection occurred despite the fact that 37%-39% of patients had metastases limited to the liver or lung. A retrospective analysis of data in Sweden suggests that up to 10% of patients with metastatic colon cancer are eligible for complete surgical resection of metastatic liver disease [7]. Second, if we congratulate ourselves for achieving a complete response with chemotherapy, why should we not do this with nonsurgical ablative techniques?…”