The Potential Antiviral Activities of Inositol (Vitamin B8 ) as a  Supplement in Human and Animal Nutrition: A Review

KORKMAZ, Serol; SAIT, Ahmet; KELES, Aysen GARGILI

doi:10.29228/johesam.16

Cited by 1 publication

(3 citation statements)

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“…In this study, myo-inositol was used at recommended safe concentrations with a maximum 500 mg•kg -1 complete cat food (527.5 mg•kg -1 based on dry matter of 94.5%). Previous studies have shown the antiviral effects of inositol and its derivatives on mostly high contagious and serious agents with DNA or RNA genomes [23,39,40]. Especially, at various concentrations, it was effective in the inhibition of Coxsackie (nonenveloped, RNA), Herpesviruses (enveloped, DNA).…”

Section: The Quantification Of Viral Load By Rt-qpcrmentioning

confidence: 99%

“…Especially, at various concentrations, it was effective in the inhibition of Coxsackie (nonenveloped, RNA), Herpesviruses (enveloped, DNA). HIV (enveloped, RNA), and Iridovirus (enveloped, RNA) threaten human and animal health [23,38,39]. Phosphate and sulphate derivatives of myo-inositol had shown antiviral activity against viruses including Coxsackie virus, Herpes Simplex virus and Iridovirus with IC50 concentrations of lower than 50 µg•ml -1 [39].…”

Section: The Quantification Of Viral Load By Rt-qpcrmentioning

confidence: 99%

“…Besides its polysaccharide structure, myo-inositol is described as a nutritional additive as vitamins, pro-vitamins and chemically well-defined substances having a similar effect in fish, dog and cat nutrition by authorities [20,21,22]. But, there is a limited number of in vitro studies on the antiviral activity of myo-inositol and its derivatives against highly contagious and serious viruses with enveloped or non-enveloped Deoxyribonucleic acid (DNA) and RNA genomes such as rhinovirus, norovirus, Coxsackie virus, herpesvirus, HIV and iridovirus [23].…”

Section: Introductionmentioning

confidence: 99%

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The effect of myo–inositol supplementation on feed physicochemical structure and viral load of dry cat food contaminated with SARS–CoV–2 by simulating sneezing

Korkmaz,

Parmaksız,

Omurtag–Korkmaz

et al. 2023

RC FCV-LUZ

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The study was carried to investigate the effect of myo–inositol supplementation on feed physicochemical structure and viral load of dry cat food contaminated with inactive SARS–CoV–2 by simulating sneezing. The most natural infection of severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) in animals is related to close contact with their owners with COVID–19 which is handling, taking care and feeding them. SARS–CoV–2 can survive on food, fomites and surfaces for extended periods related to environmental conditions. Many natural feed additives and supplements have been a candidate in recent antiviral treatment strategies against COVID–19. In this study, myo–inositol which is permitted in animal nutrition was used at different concentrations (0, 12.5, 25 and 50 mg·100 g-1 cat food) and conditions (22°C at room temperature and 4°C in the refrigerator) to investigate its effects on feed physicochemical structure and viral load of dry cat food contaminated with inactive SARS–CoV–2 by simulating sneezing. For the interactions between myo–inositol, feed structure and viral load, dry matter, moisture, water absorption index (WAI), water solubility index (WSI), pH and virus gene copy (GC) by RT–qPCR were measured. As only storage temperature affected both WAI and WSI as expected, myo–inostol supplementation dose–dependently decreased gene copy in dry cat food (IC50:366.4–581.5 mg·100 g-1 cat food) at 22°C storage temperature. Virus GC did not correlate with the dry matter, moisture content, pH and WAI after the 30 min contact time (except WSI). In conclusion, myo–inositol as a feed additive might have the potential to control serious viral infections such as COVID–19 for human–animal interactions in a One–Health context.

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Section: The Quantification Of Viral Load By Rt-qpcrmentioning

confidence: 99%