The postsubicular cortex in the rat: characterization of the fourth region of the subicular cortex and its connections

Groen, Thomas van; Wyss, J. Michael

doi:10.1016/0006-8993(90)90824-u

Cited by 239 publications

(218 citation statements)

References 45 publications

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“…To see if supragranular cortical layers were affected in young pups (postnatal day 7) exposed to 5-MT before birth, we analyzed their presubicular cortex, which has visible supragranular columns in early postnatal life (Van Groen and Wyss, 1990;Nishikawa et al, 2002). In Nissl-stained sections, the supragranular layers of the presubicular columns appeared abnormal in pups whose mothers had been injected with 5-MT (Fig.…”

Section: Resultsmentioning

confidence: 99%

Early Serotonergic Projections to Cajal-Retzius Cells: Relevance for Cortical Development

Janušonis¹,

Glunčić²,

Rakić³

2004

J. Neurosci.

135

123

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Although the serotonergic system plays an important role in various neurological disorders, the role of early serotonergic projections to the developing cerebral cortex is not well understood. Because serotonergic fibers enter the marginal zone (MZ) before birth, it has been suggested that they may influence cortical development through synaptic contacts with Cajal-Retzius (CR) cells. We used immunohistochemistry combined with confocal and electron microscopy to show that the earliest serotonergic projections to the MZ form synaptic contacts with the somata and proximal dendrites of CR cells as early as embryonic day 17. To elucidate the functional significance of these early serotonergic contacts with CR cells, we perturbed their normal development by injecting pregnant mice with 5-methoxytryptamine. Lower reelin levels were detected in the brains of newborn pups from the exposed animals. Because reelin plays an important role in the cortical laminar and columnar organization during development, we killed some pups from the same litters on postnatal day 7 and analyzed their presubicular cortex. We found that the supragranular layers of the presubicular cortex (which normally display a visible columnar deployment of neurons) were altered in the treated animals. Our results suggest a mechanism of how serotonergic abnormalities during cortical development may disturb the normal cortical organization; and, therefore, may be relevant for understanding neurological disorders in which abnormalities of the serotonergic system are accompanied by cortical pathology (such as autism).

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Section: Resultsmentioning

confidence: 99%

Early Serotonergic Projections to Cajal-Retzius Cells: Relevance for Cortical Development

Janušonis¹,

Glunčić²,

Rakić³

2004

J. Neurosci.

135

123

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“…In addition to the PoS, HD cells have been identified in the lateral dorsal nucleus of thalamus (Mizumori and Williams, 1993); the striatum (Wiener, 1993); the retrosplenial and medial prestriate cortex (Chen et al, 1994); and the lateral mammillary nuclei (Leonhard et al, 1996). Furthermore, in rats, the PoS is reciprocally connected with the ATN, the lateral dorsal thalamic nucleus, and, to a lesser degree, the retrosplenial cortex (Swanson and Cowan, 1977;van Groen and Wyss, 1990, 1992, 1995Shibata, 1993). The organization of a central representation of directional bearing undoubtedly requires the coordinated integration of neural signals from several brain areas.…”

Section: Discussionmentioning

confidence: 99%

Firing Properties of Head Direction Cells in the Rat Anterior Thalamic Nucleus: Dependence on Vestibular Input

1997

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Vestibular information influences spatial orientation and navigation in laboratory animals and humans. Neurons within the rat anterior thalamus encode the directional heading of the animal in absolute space. These neurons, referred to as head direction (HD) cells, fire selectively when the rat points its head in a specific direction in the horizontal plane with respect to the external laboratory reference frame. HD cells are thought to represent an essential component of a neural network that processes allocentric spatial information. The functional properties of HD cells may be dependent on vestibular input. Here, anterior thalamic HD cells were recorded before and after sodium arsanilate-induced vestibular system lesion. Vestibular lesions abolished the directional firing properties of HD cells. The time course of disruption in the directional firing properties paralleled the loss of vestibular function. Arsanilate-treated rats exhibited only minor changes in locomotor behavior, which were unlikely to account for the loss of direction-specific firing. Vestibular lesions also disrupted the influence of angular head velocity on anterior thalamic single-unit firing rates. Finally, a subset of anterior thalamic neurons recorded from vestibularlesioned rats exhibited a pattern of intermittent firing bursts that were distinctly unrelated to HD. This novel anterior thalamic firing pattern has not been encountered in any vestibular-intact rat. These data suggest that: (1) the neural code for directional bearing is critically dependent on vestibular information; and (2) this loss of HD cell information may represent a neurobiological mechanism to account for the orientation and navigational deficits observed after vestibular dysfunction.

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“…Here it is integrated with visual information from the geniculostriate and tectocortical pathways and then passed to the hippocampus to organize the place fields Mizumori, 1999, 2001). In contrast, Taube and colleagues have suggested that the site of visual-idiothetic integration may be the postsubiculum, which receives anatomical (van Groen and Wyss, 1990) and functional (Goodridge and Taube, 1997) inputs both from the anterior thalamus and from higher-order visual areas, including the retrosplenial cortex.…”

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confidence: 94%

Path integration in mammals

2004

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ABSTRACT:It is often assumed that navigation implies the use, by animals, of landmarks indicating the location of the goal. However, many animals (including humans) are able to return to the starting point of a journey, or to other goal sites, by relying on self-motion cues only. This process is known as path integration, and it allows an agent to calculate a route without making use of landmarks. We review the current literature on path integration and its interaction with external, location-based cues. Special importance is given to the correlation between observable behavior and the activity pattern of particular neural cell populations that implement the internal representation of space. In mammals, the latter may well be the first high-level cognitive representation to be understood at the neural level.

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The postsubicular cortex in the rat: characterization of the fourth region of the subicular cortex and its connections

Cited by 239 publications

References 45 publications

Early Serotonergic Projections to Cajal-Retzius Cells: Relevance for Cortical Development

Early Serotonergic Projections to Cajal-Retzius Cells: Relevance for Cortical Development

Firing Properties of Head Direction Cells in the Rat Anterior Thalamic Nucleus: Dependence on Vestibular Input

Path integration in mammals

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