2008
DOI: 10.1007/s12325-008-0050-x
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Abstract: Currently, surgical resection is one of only a few options for treating brain cancer. Unfortunately, postoperative tumour recurrence remains almost inevitable despite additional radiation or chemotherapy treatment following resection. Clinical observations and a growing body of experimental evidence have led to speculation that there is a population of persistent brain tumour stem cells (BTSCs)--or brain tumour initiating cells--that are difficult to completely remove surgically. Furthermore, residual BTSCs fo… Show more

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Cited by 24 publications
(18 citation statements)
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“…Recent studies indicated that GSCs and their vascular niches are the roots of proliferation and recurrence in gliomas [8], [9], [13], [29]. Thus, therapies designed to attack GSCs and vascular niches have become hot topics.…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies indicated that GSCs and their vascular niches are the roots of proliferation and recurrence in gliomas [8], [9], [13], [29]. Thus, therapies designed to attack GSCs and vascular niches have become hot topics.…”
Section: Discussionmentioning
confidence: 99%
“…Whether the currently identified glioma stem cells may be the true cellof-origin for tumor initiation and progression or the results of such processes is still an open question (86,87). Further, gliomas produce factors [e.g., urokinase plasminogen activator (uPA) and its receptor (uPAR)] that selectively attract neural stem cells (88)(89)(90)(91)(92)(93) and this has originated the question about whether stem cells may be attracted by, rather than originate, the tumor (66,(94)(95)(96). Notwithstanding, gliomas do not clash with the general cancer-stem-cell-related concept that if only a rare subset of tumor stem cells, whatever their origin, drives tumor formation, then it is important to identify this population and develop therapies that target it (97)(98)(99)(100)(101)(102)(103).…”
Section: Glioma Stem Cellsmentioning
confidence: 99%
“…While AEG-1 was first described as an HIV-1-inducible transcript in astrocytes [1], this is the first report that describes a critical role of AEG-1 in reactive astrogliosis, the first line of defense for any CNS injury [23]. The in vivo brain injury mouse model provides evidence for the induction of AEG-1 expression during gliosis, however, AEG-1 levels in injured astrocytes remained unchanged in the in vitro wound-healing model.…”
Section: Discussionmentioning
confidence: 99%
“…Gliosis is accompanied with increased expression of inflammatory cytokines and growth factors by surrounding astrocytes, which initiates a paracrine loop of signaling, potentiating proliferation, recolonization and migration of surviving cancer cells from the primary site of origin to secondary sites [20-22]. Since 70% to 95% of tumors recur from the tissues proximate to resection margins, reactive astrogliosis appears to create a favorable environment for cancer recurrence [23-26]. Thus, reactive astrogliosis is a significant phenomenon determining the rate of complete tumor clearance following conventional therapeutic interventions.…”
Section: Introductionmentioning
confidence: 99%