2015
DOI: 10.3109/02688697.2015.1071328
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Abstract: The treatment of PCNSL still remains doubtful, however possible benefit from the TTR followed with HD-MTX with/without WBRT should be reconsidered.

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Cited by 20 publications
(17 citation statements)
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References 25 publications
(17 reference statements)
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“…Weller et al (26) did a secondary analysis of the German PCNSL Study Group-1 trial, which was designed to examine the role of brain radiotherapy in the treatment of PCNSL and first demonstrated the superiority of surgical resection over biopsy on PCNSL progression-free survival and OS. Jelicic et al (27) reported the benefit of radical surgical approach in their retrospective study of 27 cases of PCNSL, but their small sample size might make their conclusions unreliable. The study of Rae et al (10) had also come to a similar conclusion, but it was subject to selection FIGURE 5 | Construction of the nomogram for estimating the probability of 1-, 3-, and 5-years overall survival for primary central nervous system lymphoma (PCNSL) (A).…”
Section: Discussionmentioning
confidence: 99%
“…Weller et al (26) did a secondary analysis of the German PCNSL Study Group-1 trial, which was designed to examine the role of brain radiotherapy in the treatment of PCNSL and first demonstrated the superiority of surgical resection over biopsy on PCNSL progression-free survival and OS. Jelicic et al (27) reported the benefit of radical surgical approach in their retrospective study of 27 cases of PCNSL, but their small sample size might make their conclusions unreliable. The study of Rae et al (10) had also come to a similar conclusion, but it was subject to selection FIGURE 5 | Construction of the nomogram for estimating the probability of 1-, 3-, and 5-years overall survival for primary central nervous system lymphoma (PCNSL) (A).…”
Section: Discussionmentioning
confidence: 99%
“…The role of craniotomy for surgical resection of PCNSL in the era of modern neurosurgical techniques requires a fresh mindset, as most data on the safety and efficacy of resection precede modern neurosurgical techniques and high-dose systemic methotrexate, and thus might be outdated ( 21 ). Recently, a few studies demonstrated a potentially beneficial impact on survival with cytoreduction in PCNSL ( 16 , 17 ). An important aspect that is lacking from this body of research is a comprehensive understanding of the complication rates, which is necessary to evaluate the risk-benefit ratio that might justify resection.…”
Section: Discussionmentioning
confidence: 99%
“…The investigators were able to demonstrate that patients who underwent partial or gross total resection had significant PFS and OS benefit compared to patients who underwent biopsy alone. Furthermore, a recent retrospective single institution study performed by Jelicic et al demonstrated prolonged OS with gross total resection over subtotal resection or biopsy in 27 patients ( 17 ). These results suggest a survival benefit with upfront cytoreductive surgical strategies for PCNSL.…”
Section: Introductionmentioning
confidence: 99%
“…Patients who received complete resection had a significantly longer overall survival compared to partial resection or biopsy only patients (Figure 2) [27]. Although this study was limited by its small sample size, retrospective nature, and lack of reported complications, it suggests that a potential benefit for gross total resection in PCNSL exists.…”
Section: Introductionmentioning
confidence: 99%