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“…The rapid rise in serum folate back to the control level between hours 28 and 32 in this subject was probably caused in part by an intravenous injection of 5 mg of folic acid' at the 30th h (arrow, Fig. 1), although with a half-life of approximately 15 min for intravenously injected folic acid (14,15), the great majority of this folic acid would have been cleared from the plasma within 2 h.…”
Section: Resultsmentioning
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“…The rapid rise in serum folate back to the control level between hours 28 and 32 in this subject was probably caused in part by an intravenous injection of 5 mg of folic acid' at the 30th h (arrow, Fig. 1), although with a half-life of approximately 15 min for intravenously injected folic acid (14,15), the great majority of this folic acid would have been cleared from the plasma within 2 h.…”
Section: Resultsmentioning
“…One notable aspect of short-term kinetic studies involved the measurement of plasma folate clearance rate following an intravenous injection of folic acid (13,37,46,54). Chanarin et al (13) observed that the clearance rate of serum folate following folic acid injection (based on Streptococcus faecalis assays) was greater in vitamin B12-deficient megaloblastic anemia patients than in normal controls.…”
Section: Short-term Kineticsmentioning
“…10 Vitamin C has been shown to increase iron absorption two-to six-fold, and to prevent oxidation and excretion of folate. 13,14 In human experiments, vitamin C deficiency impaired vasoconstriction in response to adrenergic stimuli; this effect may underlie episodes of syncope, ST-segment elevation, and apparent sudden cardiac death. 15 The mechanism by which vitamin C deficiency causes other commonly described symptoms of scurvy, including fatigue, depression, and cardiovascular events, is less understood, but may reflect vitamin C's involvement in the metabolism of carnitine, corticosteroids, and neurotransmitters.…”
Section: Discussionmentioning