“…In the HPT dataset we found exclusively upregulated ORC5, ORC6, CDC6, CDT1 (b), SLD5, POLE1, RFC1 and RPA1; additionally PSF1 and PCNA1, which are downregulated. In HTT we found exclusively upregulated genes including ORC2, MCM3, MCM4, MCM5, MCM7, MCM10, TOPBP1 (MEI1), POLA3, POLA4, POLD1, POLD3, RFC2, RFC3, RFC4, RPA1, RPA2 and RPA3 25,51 . POLA2 lays down a short RNA/DNA primer in the lagging strand synthesis 25 , and is upregulated in both HPT and HTT datasets.…”