volume 265, issue 1-2, P133-140 2003
DOI: 10.1016/j.ijpharm.2003.07.007
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Abstract: The objectives of the studies presented herein was to investigate the mechanisms of emulsion instability under thermal stress (121 degrees C) by evaluating the effects of a lipophilic drug dissolved in the internal phase of an oil-in-water (o/w) emulsion on growth rate suppression and the apparent microviscosity. Model drugs used were methyl, propyl and heptyl paraben. The o/w emulsions were prepared using medium chain triglycerides as an internal phase in aqueous glycerol solutions emulsified with phospholipi…

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