1999
DOI: 10.1590/s0100-879x1999000300002
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The photodynamic and non-photodynamic actions of porphyrins

Abstract: Porphyrias are a family of inherited diseases, each associated with a partial defect in one of the enzymes of the heme biosynthetic pathway. In six of the eight porphyrias described, the main clinical manifestation is skin photosensitivity brought about by the action of light on porphyrins, which are deposited in the upper epidermal layer of the skin. Porphyrins absorb light energy intensively in the UV region, and to a lesser extent in the long visible bands, resulting in transitions to excited electronic sta… Show more

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Cited by 57 publications
(28 citation statements)
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References 51 publications
(68 reference statements)
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“…They include PS/protein photo-binding and protein cross-linking through the coupling of two tyrosine units. Covalent cross-linking, which is regarded as a secondary reaction between photooxidation products of susceptible amino acid residues and other groups in the protein [62], leads to the formation of molecular aggregates (fig. 3).…”
Section: Photodynamic Targets At the Molecular Levelmentioning
confidence: 99%
“…They include PS/protein photo-binding and protein cross-linking through the coupling of two tyrosine units. Covalent cross-linking, which is regarded as a secondary reaction between photooxidation products of susceptible amino acid residues and other groups in the protein [62], leads to the formation of molecular aggregates (fig. 3).…”
Section: Photodynamic Targets At the Molecular Levelmentioning
confidence: 99%
“…The protein damage induced by photosensitization can occur by backbone fragmentation, oxidation of essential amino acid residues and by the formation of cross-links between proteins or between proteins and nucleic acids (Verweu and Steveninck, 1982;Afonso et al, 1999;Shacter, 2000;Macdonald and Dougherty, 2001;Davies, 2003). The reaction of singlet oxygen with electron rich side-chains residues originates new reactive species, which may damage other proteins, lipids or DNA, leading to a series of deleterious events (Davies, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…When P. acnes is bombarded with UV radiation, porphyrins absorb the UV and produce free radicals in return [27], [28]. In addition, it has been demonstrated that protein oxidation in bacteria can be as the primary determinant of bacterial reaction to radiation [29], [30].…”
Section: Resultsmentioning
confidence: 99%