The Pharmacokinetics and Interactions of Ivermectin in Humans—A Mini-review

Canga, Aránzazu González; Sahagún, Ana M.; Diez, M. José; Martínez, Nélida Fernández; Sierra, Matilde; Vieitez, Juan José García

doi:10.1208/s12248-007-9000-9

Cited by 310 publications

(255 citation statements)

References 30 publications

Supporting

Mentioning

238

Contrasting

Unclassified

Order By: Relevance

“…In invertebrate nematodes, avermectins specifically bind to glutamate-gated chloride channels present in nerve and muscle cells, causing paralysis and reduced ability to reproduce (27). Avermectins are orally active and distributed to most parts of the human body, including the lungs (24,28). Ivermectin does not bind ligand-gated chloride channels in mammals, possibly due to impermeability of the bloodbrain barrier and nonspecific pumps that prevent it from reaching the central nervous system (20,27).…”

mentioning

confidence: 99%

Anthelmintic Avermectins Kill Mycobacterium tuberculosis, Including Multidrug-Resistant Clinical Strains

Lim

Vilchèze

et al. 2013

Antimicrob Agents Chemother

121

110

View full text Add to dashboard Cite

bAvermectins are a family of macrolides known for their anthelmintic activities and traditionally believed to be inactive against all bacteria. Here we report that members of the family, ivermectin, selamectin, and moxidectin, are bactericidal against mycobacterial species, including multidrug-resistant and extensively drug-resistant clinical strains of Mycobacterium tuberculosis. Avermectins are approved for clinical and veterinary uses and have documented pharmacokinetic and safety profiles. We suggest that avermectins could be repurposed for tuberculosis treatment.

show abstract

mentioning

confidence: 99%

Anthelmintic Avermectins Kill Mycobacterium tuberculosis, Including Multidrug-Resistant Clinical Strains

Lim

Vilchèze

et al. 2013

Antimicrob Agents Chemother

121

110

View full text Add to dashboard Cite

show abstract

“…Following oral administration, mean peak plasma concentration occurs approximately 4 h after dosing, a second peak at 6-12 h probably arising because of enterohepatic recycling of the drug, with the plasma half-life of ivermectin being around 12 h. [32][33][34] Dermal microfilarial loads are reduced by 78% within 2 days, and by some 98% within 2 weeks of treatment, remaining at extremely low levels for about 12 months. As lowest levels of microfilariae occur well after ivermectin administration, they are not necessarily killed when plasma drug levels are highest.…”

Section: The Present: a Puzzlementioning

confidence: 99%

“…It has already been demonstrated that oral solutions produce twice the systemic availability than solid forms (tablets or capsules). 34 As shown in Appendix 2, the possibility of novel systems for delivering ivermectin opens up a plethora of opportunities for usage of the drug against currently targeted diseases, as well as realizing its potential to combat a totally new range of diseases and conditions. It may therefore be likely that novel formulations and delivery systems, such as those in Appendix 2, as well as ivermectin-containing skin patches, slow-release formulations, oral solutions, ivermectin-impregnated clothing or newly discovered time-sensitive shape-shifting materials, may become innovative and effective means of delivering the drug in the near future.…”

Section: Anti-cancermentioning

confidence: 99%

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations

2017

View full text Add to dashboard Cite

Over the past decade, the global scientific community have begun to recognize the unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe unearthed from soil in Japan. Work on ivermectin has seen its discoverer, Satoshi Ōmura, of Tokyo's prestigious Kitasato Institute, receive the 2014 Gairdner Global Health Award and the 2015 Nobel Prize in Physiology or Medicine, which he shared with a collaborating partner in the discovery and development of the drug, William Campbell of Merck & Co. Incorporated. Today, ivermectin is continuing to surprise and excite scientists, offering more and more promise to help improve global public health by treating a diverse range of diseases, with its unexpected potential as an antibacterial, antiviral and anti-cancer agent being particularly extraordinary.

show abstract

“…Certain fibers can be appropriate fat replacements in meat emulsion products because they show excellent water holding capacity (Hughes, Cofrades, & Troy, 1997). In addition, DF promotes several biological activities that benefit the absorption of essential nutrients (González Canga et al, 2004;Zhang et al, 2001). Hence, numerous studies have discussed the use of DF as a promising healthier alternative in the production of low-fat meats.…”

Section: Introductionmentioning

confidence: 99%

“…Tomato peel, an undervalued agro-industrial waste, contains nondigestible fiber with numerous physiological effects and therapeutic applications (González Canga et al, 2004;Majzoobi, Ghavi, Farahnaky, Jamalian, & Mesbahi, 2011). Previously, our group demonstrated that crushed tomato peel powder functioned as an excellent fat substitute in sausages (Wang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Effects of tomato peel as fat replacement on the texture, moisture migration, and sensory quality of sausages with varied fat levels

Wang

Xie

et al. 2017

CyTA - Journal of Food

View full text Add to dashboard Cite

(2017) Effects of tomato peel as fat replacement on the texture, moisture migration, and sensory quality of sausages with varied fat levels, CyTA -Journal of Food, 15:4, 582-591, DOI: 10.1080/19476337.2017 To link to this article: https://doi.org/10. 1080/19476337.2017 The influence of tomato peel powder on the water holding capacity, microstructural character, and sensory quality of reduced-fat sausages during storage was investigated. In this work, rough tomato peels were crushed to powders of 0.15-and 0.025-mm particle sizes by conventional crushing and airflow ultramicro-crushing, respectively. Replacing fat with tomato powder significantly increased the amount of free water in sausages after storage, as determined by lowfield nuclear magnetic resonance imaging. However, less free water was present in sausage samples that were already of the reduced-fat variety. Sausages with the conventional mechanically crushed tomato powder showed denser and more compact structures than sausages with those using the airflow ultramicro-crushed powder. Compared to the case of sausages with higher levels (3%) of tomato peel, granulation was more obvious (p < 0.05) in samples with lower levels of tomato peel (0.5%), and more pores were observed in the samples with higher tomato powder content. The results indicated that low doses of conventionally crushed tomato powder as a potential fat substitute could be used in the sausage industry.Efectos de la piel de tomate como sustituto de grasa en la textura, la migración de humedad y la calidad sensorial de salchichas con distintos niveles de grasa RESUMEN Se investigó la influencia que tiene la piel de tomate en polvo en la capacidad de retención de agua, el carácter microestructural y la calidad sensorial de salchichas de bajo contenido graso durante su almacenamiento. Para efectos de esta investigación se pulverizaron pieles de tomate rugosas empleando trituración convencional y trituración ultramicro con flujo de aire hasta reducirlas a partículas de polvo de 0,15 y 0,025 mm, respectivamente. Las imágenes obtenidas por resonancia magnética nuclear de campo bajo mostraron que la sustitución de grasas por piel de tomate en polvo aumentó significativamente la cantidad de agua libre en las salchichas después de almacenarlas. Sin embargo, en aquellas muestras de salchicha que ya eran de bajo contenido graso se detectó menos agua libre. Asimismo, se comprobó que las salchichas con tomates en polvo triturados mediante el método mecánico convencional presentan estructuras más densas y más compactas que aquellas con tomate en polvo obtenido mediante trituración ultramicro con flujo de aire. Comparativamente, se observó que la granulación fue más evidente (p < 0,05) en aquellas muestras de salchichas que contenían niveles más bajos de piel de tomate (0,5%) que en aquellas con niveles más elevados de piel de tomate (3%); además, se detectó mayor número de poros en las muestras con contenido de tomate en polvo más elevado. Estos resultados indican que en la industria salchichera pueden ...

show abstract

The Pharmacokinetics and Interactions of Ivermectin in Humans—A Mini-review

Cited by 310 publications

References 30 publications

Anthelmintic Avermectins Kill Mycobacterium tuberculosis, Including Multidrug-Resistant Clinical Strains

Anthelmintic Avermectins Kill Mycobacterium tuberculosis, Including Multidrug-Resistant Clinical Strains

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations

Effects of tomato peel as fat replacement on the texture, moisture migration, and sensory quality of sausages with varied fat levels

Contact Info

Product

Resources

About