The pH‐Sensitive Optical Fiber Integrated CMCS‐PA@Fe Hydrogels for Photothermal Therapy and Real‐Time Monitoring of Infected Wounds

Abstract

Bacterial infections are one of the biggest threats to wound healing. Despite significant efforts in wound condition monitoring and treatment, significant challenges remain in real‐time wound monitoring and timely treatment. Herein, a kind of hydrogel with dual functions, which can not only quickly diagnose wound bacterial infection but also provide timely and effective treatment is developed. First, Carborxymethy chitosan (CMCS)‐Protocatechualdehyde (PA)@Fe hydrogels with double dynamic bonds are prepared by chelating PA@Fe with CMCS. Second, the pH‐sensitive Polydimethylsiloxane (PDMS) optical fibers are integrated into the CMCS‐PA@Fe hydrogels to obtain the pH‐sensitive optical fiber/CMCS‐PA@Fe hydrogels that exhibit good real‐time monitoring of the wound healing process. The tissue adhesion and self‐healing properties of the pH‐sensitive optical fiber/CMCS‐PA@Fe hydrogels can adapt to the movement and stretching of the skin. Meanwhile, with the assistance of the photothermal effect, the hydrogels have a high antibacterial effect (>99.9%). In addition, the pH‐sensitive optical fiber/CMCS‐PA@Fe hydrogels also show an excellent therapeutic effect in the wound infection model. Moreover, reliable and timely wound pH information can be sent to intelligent devices through microcomputers to monitor the healing status. Overall, the pH‐sensitive optical fiber/CMCS‐PA@Fe hydrogels provide an entirely new platform for developing smart, real‐time diagnostics and timely wound treatment.

A Novel Multifunctional Crosslinking PVA/CMCS Hydrogel Containing Cyclic Peptide Actinomycin X2 and PA@Fe with Excellent Antibacterial and Commendable Mechanical Properties

“…It was determined that the stretching vibration of OÀ H and CÀ H in the CMCS was responsible for the weak absorption peak at 2908 cm À 1 . [39] A peak at 1637 cm À 1 was attributed to C=N stretching formed by the CMCS and PA@Fe,, [24] respectively. The peaks at 1085 cm À 1 was attributed to CÀ O and CÀ OÀ C stretching vibration.…”

Near-IR-Regulated Composite Hydrogel with Real-Time Infection Monitoring and a Combined Antibacterial Effect for Efficient Wound Management

“…Skin, which serves as the largest protective barrier of the human body, is easily damaged by accidents, surgery, and diseases and forms wounds. 1,2 Skin wounds greatly reduce the quality of a patient's life and even threaten the health of humans. Therefore, wound management, especially for infected wounds, has attracted more and more attention in clinic.…”

“…Skin, which serves as the largest protective barrier of the human body, is easily damaged by accidents, surgery, and diseases and forms wounds. , Skin wounds greatly reduce the quality of a patient’s life and even threaten the health of humans. Therefore, wound management, especially for infected wounds, has attracted more and more attention in clinic. − The ideal wound management strategy should have the following characteristics: (1) real-time monitoring of the infection status; (2) an efficient antibacterial effect; (3) a suitable platform that integrates real-time-monitoring ability and efficient antibacterial performance.…”

Highly Stretchable, Transparent, and Adhesive Double-Network Hydrogel Dressings Tailored with Fish Gelatin and Glycyrrhizic Acid for Wound Healing

“…Different types of wound dressings have been developed and used to promote wound healing, such as cryo-gel, membranes, , electrospinning scaffolds, − hydrogels, etc. Among them, hydrogels represent one of the ideal candidates to replace traditional wound dressings due to their inherent advantages, such as biocompatibility, sustained release ability, water retention, ductility, excellent cell affinity, self-healing, and injectability. − These valuable characteristics enable the hydrogels to integrate with the surrounding tissue . Interestingly, in nature, marine mussels can firmly affix on various wet surfaces by the overproduction of special mussel foot proteins, where the catholic amino acid L-3,4-dihydroxyphenylalanine has been found to play the major role .…”