The pH-dependent multiple nanozyme activities of copper-cerium dioxide and its application in regulating intracellular oxygen and hydrogen peroxide levels

Liu, Jing; Zhu, Yu; Fan, You; Gong, Lin; Zhu, Xiaohua; Zhang, Youyu; Liu, Meiling; Yao, Shouzhuo

doi:10.1016/j.jcis.2023.10.050

Cited by 9 publications

(3 citation statements)

References 26 publications

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“…Therefore, breaking the pH limitation is the key to highly active POD, and results from these earlier studies may offer insights for the construction of novel and highly efficient POD-like nanozymes to broaden the potential of their application in the diagnosis and treatment of diseases. 112 In addition, considering the harsh repair microenvironment of DFU, the therapeutic effect of a single POD activity is far from sufficient. Zhu et al 113 synthesized a nanozyme where MnO 2 was encapsulated with polydopamine (PDA) doped with bioactive glasses (BGs), which possessed antioxidant, antimicrobial, and pro-healing abilities.…”

Section: Pod-like Activity Ros Mainly Hydrogen Peroxide Superoxide An...mentioning

confidence: 99%

“…The cleverly designed fiber nanozyme possessed both POD-like activity and CAT-like activity, which are synergistic for antibacterial, anti-inflammatory and vascular regeneration promotion to accelerate the healing of DFU. Therefore, breaking the pH limitation is the key to highly active POD, and results from these earlier studies may offer insights for the construction of novel and highly efficient POD-like nanozymes to broaden the potential of their application in the diagnosis and treatment of diseases …”

Section: Mechanisms Of Nanozymes For Dfu Treatmentmentioning

confidence: 99%

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Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Xiao,

Zhao,

DuBois

et al. 2024

ACS Biomater. Sci. Eng.

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Diabetic foot ulcers (DFU) are chronic, refractory wounds caused by diabetic neuropathy, vascular disease, and bacterial infection, and have become one of the most serious and persistent complications of diabetes mellitus because of their high incidence and difficulty in healing. Its malignancy results from a complex microenvironment that includes a series of unfriendly physiological states secondary to hyperglycemia, such as recurrent infections, excessive oxidative stress, persistent inflammation, and ischemia and hypoxia. However, current common clinical treatments, such as antibiotic therapy, insulin therapy, surgical debridement, and conventional wound dressings all have drawbacks, and suboptimal outcomes exacerbate the financial and physical burdens of diabetic patients. Therefore, development of new, effective and affordable treatments for DFU represents a top priority to improve the quality of life of diabetic patients. In recent years, nanozymes-based diabetic wound therapy systems have been attracting extensive interest by integrating the unique advantages of nanomaterials and natural enzymes. Compared with natural enzymes, nanozymes possess more stable catalytic activity, lower production cost and greater maneuverability. Remarkably, many nanozymes possess multienzyme activities that can cascade multiple enzymecatalyzed reactions simultaneously throughout the recovery process of DFU. Additionally, their favorable photothermal-acoustic properties can be exploited for further enhancement of the therapeutic effects. In this review we first describe the characteristic pathological microenvironment of DFU, then discuss the therapeutic mechanisms and applications of nanozymes in DFU healing, and finally, highlight the challenges and perspectives of nanozyme development for DFU treatment.

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Section: Pod-like Activity Ros Mainly Hydrogen Peroxide Superoxide An...mentioning

confidence: 99%

Section: Mechanisms Of Nanozymes For Dfu Treatmentmentioning

confidence: 99%

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Xiao,

Zhao,

DuBois

et al. 2024

ACS Biomater. Sci. Eng.

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“…Ceria nanoparticles have attracted significant interest in catalysis and sensing, as well as antioxidation due to the presence of oxygen vacancies and the coexistence of Ce 3+ and Ce 4+ oxidation states. 1–5 In the catalytic field, nanoceria as a nanozyme can overcome the intrinsic drawbacks of natural enzymes such as high cost, low stability, and difficulty in storage. 6,7 As a result, nanoceria is emerging as an effective artificial enzyme in multiple enzyme-mimic activities, such as oxidase, 8–10 catalase, 11,12 peroxidase 13,14 and superoxide dismutase.…”

Section: Introductionmentioning

confidence: 99%

Shaddock peel-loaded CeO₂ composites with peroxidase-like activity for dye degradation and trace detection of ascorbic acid

Lv,

Gao,

et al. 2024

New J. Chem.

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Optical and Catalytic Properties of Nanozymes for Colorimetric Biosensors: Advantages, Limitations, and Perspectives

Panferov,

Liu

2024

Advanced Optical Materials

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Detection of colorimetric signals is commonly used in various analytical methods and for testing in non‐laboratory and resource‐limited settings. The performance of colorimetric assays is largely based on nanoparticles and their unique optical properties. Multifunctional nanoparticles combining optical and enzyme‐like catalytic properties—known as nanozymes—hold great promise for analytical applications as signal‐generating labels. However, the extensive focus on the catalytic properties leaves their unique optical properties overlooked. In this article, the use of the optical and catalytic properties of nanozymes is reviewed for analytical applications relying on the inherent optical properties of nanozymes, the colorimetric detection of a catalytically‐formed product, and colorimetric changes of nanoparticles caused by the catalytically‐formed product. The impact of the extinction coefficient of nanozymes and reaction products, as well as the kinetic parameters of nanozymes on the sensitivity and limit of detection of assays, are quantitatively evaluated. Finally, the existing limitations and prospects of nanozymes for colorimetric biosensors are summarized.

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The pH-dependent multiple nanozyme activities of copper-cerium dioxide and its application in regulating intracellular oxygen and hydrogen peroxide levels

Cited by 9 publications

References 26 publications

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Shaddock peel-loaded CeO₂ composites with peroxidase-like activity for dye degradation and trace detection of ascorbic acid

Optical and Catalytic Properties of Nanozymes for Colorimetric Biosensors: Advantages, Limitations, and Perspectives

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The pH-dependent multiple nanozyme activities of copper-cerium dioxide and its application in regulating intracellular oxygen and hydrogen peroxide levels

Cited by 9 publications

References 26 publications

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Shaddock peel-loaded CeO2 composites with peroxidase-like activity for dye degradation and trace detection of ascorbic acid

Optical and Catalytic Properties of Nanozymes for Colorimetric Biosensors: Advantages, Limitations, and Perspectives

Contact Info

Product

Resources

About

Shaddock peel-loaded CeO₂ composites with peroxidase-like activity for dye degradation and trace detection of ascorbic acid