The Peyer’s Patch Homing Receptor

Hu, Mickey C.T.; Holzmann, Bernhard; Crowe, David T.; Neuhaus, Heinz

doi:10.1007/978-3-642-78253-4_10

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…Integrins are heterodimers formed by a combination of one of 17 α and 8 β chains in humans (Shimizu et al, 1999). The integrins α4β1(VLA-4), αLβ2 (LFA-1), Mac-1 and α4β7 have major functions in leukocyte-endothelial cell interactions (Hu et al, 1993;Larson and Springer, 1990;Lobb and Hemler, 1994;Stewart et al, 1995). LFA-1 is almost ubiquitously expressed on normal lymphocytes, and the highest levels are seen on activated cells.…”

Section: (Iii) Tight Adhesionmentioning

confidence: 99%

The parting of the endothelium: miracle, or simply a junctional affair?

Johnson‐Léger¹,

Aurrand-Lions²,

Imhof³

2000

Journal of Cell Science

153

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Leukocyte extravasation from the blood across the endothelium is vital for the functioning of the immune system. Our understanding of the early steps of this process has developed rapidly. However, it is still unclear how leukocytes undergo the final step, migrating through the junctions that mediate adhesion between adjacent endothelial cells, while preserving the barrier function of the endothelium. The first stage of transmigration - tethering and rolling - is mediated by interactions between selectins on the surface of leukocytes and glycosylated proteins such as GlyCAM-1 on the surface of endothelial cells. Stimulation of the leukocyte by chemokines then induces tight adhesion, which involves binding of activated leukocyte integrins to endothelial ICAM-1/VCAM-1 molecules. Passage of the leukocyte across the endothelium appears to require delocalization of certain endothelial cell molecules and proteolytic degradation of junctional complexes.

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Section: (Iii) Tight Adhesionmentioning

confidence: 99%

The parting of the endothelium: miracle, or simply a junctional affair?

Johnson‐Léger¹,

Aurrand-Lions²,

Imhof³

2000

Journal of Cell Science

153

View full text Add to dashboard Cite

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“…Integrins are heterodimers formed by a combination of one alpha and one beta chain (Shimizu et al 1999). The integrins a4b1 (VLA-4) and aLb2 (LFA-1) have major functions in leukocyte-endothelial cell interactions (Hu et al 1993;R.S. Larson and Springer 1990;Lobb and Hemler 1994;Stewart et al 1995).…”

Section: Activation Of Integrins and Tight Adhesionmentioning

confidence: 99%

Forging the endothelium during inflammation: pushing at a half-open door?

Johnson‐Léger

Imhof

2003

Cell and Tissue Research

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During an inflammatory response, changes in the adhesive properties of the endothelium occur that enable normally non-adherent blood-borne leukocytes to adhere and subsequently to traverse the endothelium through small gaps at inter-cellular junctions. This review concentrates on the role played by inter-endothelial adhesion molecules during transmigration and the way in which their expression may be regulated during inflammation. We show that the final "open" signals that lead to the formation of clefts between adjacent endothelial cells may be derived from inflamed tissue underlying the endothelium and from activated leukocytes.

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