The persistence of a broad range of antibiotics during calve, pig and broiler manure storage

Abstract

After administration to livestock, a large fraction of antibiotics are excreted unchanged via excreta and can be transferred to agricultural land. For effective risk assessment a critical factor is to determine which antibiotics can be expected in the different environmental compartments. After excretion, the first relevant compartment is manure storage. In the current study, the fate of a broad scope of antibiotics (n = 46) during manure storage of different livestock animals (calves, pigs, broilers) was investigated. Manure samples were fortified with antibiotics and incubated during 24 days. Analysis was carried out by LC-MS. The dissipation of the antibiotics was modelled based on the recommendations of FOCUS working group. Sulphonamides relatively quickly dissipate in all manure types, with a DT90 of in general between 0.2 and 30 days. Tetracyclines (DT90 up to 422 days), quinolones (DT90 100-5800 days), macrolides (DT90 18-1000 days), lincosamides (DT90 135-1400 days) and pleuromutilins (DT90 of 49-1100 days) are in general much more persistent, but rates depend on the manure type. Specifically lincomycin, pirlimycin, tiamulin and most quinolones are very persistent in manure with more than 10% of the native compound remaining after a year in most manure types. For all compounds tested in the sub-set, except the macrolides, the dissipation was an abiotic process. Based on the persistence and current frequency of use, oxytetracycline, doxycycline, flumequine and tilmicosin can be expected to end up in environmental compartments. Ecotoxicological data should be used to further prioritize these compounds.

Preparation of Hollow Flower-Like Microspherical β-Bi2O3/BiOCl Heterojunction and High Photocatalytic Property for Tetracycline Hydrochloride Degradation

“…At present, the abuse of antibiotics has caused it to enter our soil and water in various ways, such as the medical industry wastewater, animal feces, and so on. Antibiotics have had a serious impact on the environmental problems of our country [5][6][7]. When the antibiotic wastewater enters the water body, as an external factor, it will break the original biological chain, damage the environment, and endanger people's health [8,9].…”

Antimicrobiële resistentie en residuen van diergeneesmiddelen (antibiotica) in een circulaire veehouderij : Tegengaan van verspreiding via mest en milieu

“…Lahr et al (2018) veronderstellen dat het diepere gedeelte van de mestkelder anaeroob is en dat daardoor diergeneesmiddelen mogelijk langzamer afbreken. Berendsen et al (Berendsen et al, 2018) concluderen dat ook mest type een rol speelt bij het afbraakproces. Daarbij is het type geneesmiddel ook belangrijk.…”

“…Daarom is het belangrijk om op basis van (hoe vaak deze middelen worden gebruik en) ecotoxicologische studies ten aanzien van hun persistentie in mest en de ecosystemen deze middelen te classificeren (Berendsen et al, 2018).…”

“…Bijvoorbeeld toelatingscommissies en de controle-instanties evenals dierartsen en veehouders/sters zouden ook rekening kunnen/moeten houden met de gevolgen van genees-en andere middelen op ecosystemen (Scheffczyk et al, 2015). Hiervoor een kennis-basis zou ontwikkeld moeten worden op basis van ecotoxicologische studies om deze middelen qua risico's te rangschikken (Lahr et al, 2017;Berendsen et al, 2018).…”

Silicon dioxide nanoparticles have contrasting effects on the temporal dynamics of sulfonamide and β-lactam resistance genes in soils amended with antibiotics

“…It is believed that continuous, improper and high usage of antibiotics have contributed to the evolution and development of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in various receiving environments (Brown et al 2006, Laxminarayan et al 2013. Antibiotics, different from other classes of drugs, are poorly absorbed by animals, with around 30%-90% of doses excreted to the environment through manure in the form of the original antibiotics (Thames et al 2012, Zhou et al 2013, Zhan and Xiao 2017, Berendsen et al 2018. The long-term selection pressure imposed by antibiotics can contribute to the enrichment and dispersal of ARGs in the environment (Hu et al 2016).…”