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Cited by 57 publications
(49 citation statements)
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References 39 publications
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“…5 The underlying intracellular pathways and molecular mechanisms have been subject of intensive investigations recent years. 5,7,19,20,23 In accordance with these studies, we report here impaired endothelium-dependent ACh-induced relaxation of isolated aortic rings of aging rats (Fig. 3).…”
Section: Discussionsupporting
confidence: 91%
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“…5 The underlying intracellular pathways and molecular mechanisms have been subject of intensive investigations recent years. 5,7,19,20,23 In accordance with these studies, we report here impaired endothelium-dependent ACh-induced relaxation of isolated aortic rings of aging rats (Fig. 3).…”
Section: Discussionsupporting
confidence: 91%
“…The endothelium-independent relaxation induced by the exogenously administered NO donor SNP was not impaired by aging, indicating the normal dilative capacity of the vascular smooth muscle. In contrast with a previous work using epinephrine for precontraction, 37 we found a significant decrease in contraction forces induced by PE in aging animals that was in line with our previous studies 7,21 and may be due to alterations in receptor density and/or receptor/effector coupling. Similar to the effects of aspirin, 23 the SODmimetic tempol, 19 or catalytic peroxynitrite decomposition, 7 CuAsp treatment significantly enhanced the endotheliumdependent vasorelaxations (i.e., improved the endothelial function) in rats with advanced aging, whereas endotheliumindependent vasorelaxation was only slightly increased.…”
Section: Discussionsupporting
confidence: 88%
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“…In obesity, with its inherant increase in FA oxidation, there is increased myocardial oxidative stress [62]. In animal studies free radicals appear to impair both vascular and LV systolic and diastolic function since decomposition of free radicals lead to improvement of these parameters [63]. Supporting this theory that not all of the cardiac dysfunction that is seen with obesity is due to apoptosis-related injury, are studies showing improvement in cardiac function after significant weight loss [64,65].…”
Section: Obesity and Myocardial Metabolismmentioning
confidence: 99%