2019
DOI: 10.1111/micc.12554
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Abstract: Vascular pericytes provide critical contributions to the formation and integrity of the blood vessel wall within the microcirculation. Pericytes maintain vascular stability and homeostasis by promoting endothelial cell junctions and depositing extracellular matrix (ECM) components within the vascular basement membrane, among other vital functions. As their importance in sustaining microvessel health within various tissues and organs continues to emerge, so does their role in a number of pathological conditions… Show more

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Cited by 42 publications
(29 citation statements)
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“…However, these opposing views come from diverse model systems and organs, and likely differ in various angiogenic contexts. Recent data from Payne et al reveal a potential middle ground where pericyte and endothelial tip cells co‐migrate, taking turns to lead the new capillary sprout (Payne et al, ). The relative position of pericytes and endothelial cells was hypothesized to be dependent upon fluctuations in the availability of ligands such as PDGF‐BB at the angiogenic front.…”
Section: Building the Wall: From A Vascular Network To A Neurogliovasmentioning
confidence: 99%
“…However, these opposing views come from diverse model systems and organs, and likely differ in various angiogenic contexts. Recent data from Payne et al reveal a potential middle ground where pericyte and endothelial tip cells co‐migrate, taking turns to lead the new capillary sprout (Payne et al, ). The relative position of pericytes and endothelial cells was hypothesized to be dependent upon fluctuations in the availability of ligands such as PDGF‐BB at the angiogenic front.…”
Section: Building the Wall: From A Vascular Network To A Neurogliovasmentioning
confidence: 99%
“…Thus, this unique configuration of ECM proteins (e.g., Type IV Collagen (Col-IV), laminins, perlecan) surrounding microvascular endothelia and pericytes can offer another criteria for their identification [32]. Ultimately, pericytes are the best identified through a combination of pericyte and endothelial markers, rigorous assessment of their morphology (which may include some slight heterogeneity [33,34]), and their location within microvascular networks. Coupling these benchmarks with next generation sequencing approaches and single-cell analysis will sharpen existing pericyte-specific tools, and allow greater insight into critical questions such as when terminally differentiated pericytes first emerge during embryonic development and how they expand their coverage along the rapidly developing vasculature.…”
Section: Pericyte Differentiationmentioning
confidence: 99%
“…They are involved in the preservation of vascular stability and homeostasis including, but not restricted to, maintenance of vessel structure, regulation of blood flow, vascular permeability, and remodeling of the extracellular matrix (ECM). They are also essential for normal blood vessel development [14]. Unfortunately, in the case of abnormal pericyte function or the loss of numbers of pericytes can be associated with some pathologies such as fibrosis; ischemic organ failure; diabetesrelated complications; pulmonary hypertension; Alzheimer disease; and cancer promoting tumor growth, metastasis, and angiogenesis.…”
Section: Pericyte Functionmentioning
confidence: 99%