The performance of licensed rotavirus vaccines and the development of a new generation of rotavirus vaccines: a review

Wang, Yuxiao; Li, Jingxin; Liu, Pei; Zhu, Fengcai

doi:10.1080/21645515.2020.1801071

Cited by 6 publications

(3 citation statements)

References 225 publications

(240 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RVA disease is mainly prevented by vaccination. Currently, six vaccines have been licensed for use in humans: Rotarix™ (GlaxoSmithKline, Belgium), which contains G1P[8]; RotaTeq™ (Merck and Co, USA), which contains a mixture of four mono-reassortants carrying the genes encoding human G1–G4 and P[7] from the bovine strain and the fifth reassortant strain containing P1A[8] genotypes from a human strain; Rotavac™ (Bharat Biotech International Ltd., India), a bovine–human reassortant contains G9P[11]; Lanzhou lamb rotavirus vaccine (LLR) (Lanzhou Institute of Biological Products, China), which contains G10P[12]; Rotavin-M1™ (POLYVAC-Vietnam, Vietnam), which contains G1P[8]; and RotaSiil™ (Serum Institute of India Ltd., India), which is a lyophilized pentavalent vaccine containing human–bovine reassortant strains G1, G2, G3, G4, and G9 [ 10 ]. The available vaccines for use in bovines are a bivalent vaccine containing G10P[11] and G6P[1], and a monovalent vaccine containing G6P[5] [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Co-Surveillance of Rotaviruses in Humans and Domestic Animals in Central Uganda Reveals Circulation of Wide Genotype Diversity in the Animals

Bwogi,

Karamagi,

Byarugaba

et al. 2023

Viruses

View full text Add to dashboard Cite

Rotavirus genotypes are species specific. However, interspecies transmission is reported to result in the emergence of new genotypes. A cross-sectional study of 242 households with 281 cattle, 418 goats, 438 pigs, and 258 humans in Uganda was undertaken between 2013 and 2014. The study aimed to determine the prevalence and genotypes of rotaviruses across co-habiting host species, as well as potential cross-species transmission. Rotavirus infection in humans and animals was determined using NSP3 targeted RT-PCR and ProSpecT Rotavirus ELISA tests, respectively. Genotyping of rotavirus-positive samples was by G- and P-genotype specific primers in nested RT-PCR assays while genotyping of VP4 and VP7 proteins for the non-typeable human positive sample was done by Sanger sequencing. Mixed effect logistic regression was used to determine the factors associated with rotavirus infection in animals. The prevalence of rotavirus was 4.1% (95% CI: 3.0–5.5%) among the domestic animals and 0.8% (95% CI: 0.4–1.5%) in humans. The genotypes in human samples were G9P[8] and P[4]. In animals, six G-genotypes, G3(2.5%), G8(10%), G9(10%), G11(26.8%), G10(35%), and G12(42.5%), and nine P-genotypes, P[1](2.4%), P[4](4.9%), P[5](7.3%), P[6](14.6%), P[7](7.3%), P[8](9.8%), P[9](9.8%), P[10](12.2%), and P[11](17.1%), were identified. Animals aged 2 to 18 months were less likely to have rotavirus infection in comparison with animals below 2 months of age. No inter-host species transmission was identified.

show abstract

Section: Introductionmentioning

confidence: 99%

Co-Surveillance of Rotaviruses in Humans and Domestic Animals in Central Uganda Reveals Circulation of Wide Genotype Diversity in the Animals

Bwogi,

Karamagi,

Byarugaba

et al. 2023

Viruses

View full text Add to dashboard Cite

show abstract

“…Nevertheless, vaccination has a highly positive impact, reducing the burden on public health associated with rotavirus infections. Moreover, the rotavirus vaccine landscape is growing with novel prequalified vaccines and other candidates under development [ 13 ]. In this context, new and/or improved analytical tools for high-throughput in-process product quality control (QC) during vaccine development and manufacturing are needed.…”

Section: Introductionmentioning

confidence: 99%

Biolayer Interferometry Analysis for a Higher Throughput Quantification of In-Process Samples of a Rotavirus Vaccine

et al. 2022

View full text Add to dashboard Cite

Rotavirus A infection is a global leading cause of severe acute gastroenteritis associated with life-threatening diarrheal episodes in infants and young children. The disease burden is being reduced, namely due to a wider access to rotavirus vaccines. However, there is a demand to expand rotavirus vaccination programs, and to achieve this, it is critical to improve high-throughput in-process product quality control and vaccine manufacturing monitoring. Here, we present the development of an analytical method for the quantification of rotavirus particles contained in a licensed vaccine. The binding of rotavirus proteins to distinct glycoconjugate receptors and monoclonal antibodies was evaluated using biolayer interferometry analysis, applied on an Octet platform. The antibody strategy presented the best results with a linear response range within 2.5 × 107–1.0 × 108 particles·mL−1 and limits of detection and quantification of 2.5 × 106 and 7.5 × 106 particles·mL−1, respectively. Method suitability for the quantification of in-process samples was shown using samples from different manufacturing stages and their titers were comparable with the approved CCID(50) method. This cell-free method enables a fast and high-throughput analysis, compatible with time constraints during bioprocess development and it is suitable to be adapted to other viral particle-based drug products.

show abstract

“…13 However, the efficacy of LLR has not been approved in the international market and another vaccine RotaTeq RV which is internationally approved was licensed in China in 2018. 14 The RVs which infect humans is very diverse and there 36 G types and 51 P types of RVs (G1-G36 and P [1]-P[51]) based on the RCWG international classification. 15 A study on the isolates of RVs in China reported G3, G1, G2 and G4 as the most prevalent G type, and, P [8] and P [4] as the most prevalent P types.…”

Section: Introductionmentioning

confidence: 99%

A Clinical Nursing Care Study on the Prevalence of Rotavirus Infection and Acute Diarrhea in Vaccinated Chinese Pediatric Population from 2019–2022

Fan¹

2022

IDR

View full text Add to dashboard Cite

To investigate the prevalence of rotavirus infection and acute diarrhea after immunization and further assess the quality of nursing care provided by the nurses to such patients. Methods: A total of 432 children aged 3-36 months with acute diarrhea between February 2019 and March 2022 were enrolled, and rotavirus testing was performed within 24 h using a rotavirus enzyme immunoassay kit. Clinical characteristics were evaluated, and regression analysis was performed. Results: Eighty vaccinated children (18.5%) were confirmed to have rotavirus infection out of 432 children. The prevalence of rotavirus positivity was the highest at 20-28 months (22 cases, 24.44%) and 11-19 months age group (27 cases, 22.50%). There is a significant association between rotavirus infection and hygiene score (p = 0.009). Based on the association with quality of nursing care, rotavirus infection was association with "appropriate care" (p = 0.001). Conclusion:Rotavirus infection was strongly associated with poor hygiene score which may be due to the hygienic nature of the mother and her family. Nursing care assessments revealed a huge gap between nurses and the guardians, which reflects the behavior of Chinese nurses. Thus, an intervention is required by the policymakers for implementing effective strategies of quality nursing for the improvement of the pediatric patients with rotavirus gastroenteritis.

show abstract

The performance of licensed rotavirus vaccines and the development of a new generation of rotavirus vaccines: a review

Cited by 6 publications

References 225 publications

Co-Surveillance of Rotaviruses in Humans and Domestic Animals in Central Uganda Reveals Circulation of Wide Genotype Diversity in the Animals

Co-Surveillance of Rotaviruses in Humans and Domestic Animals in Central Uganda Reveals Circulation of Wide Genotype Diversity in the Animals

Biolayer Interferometry Analysis for a Higher Throughput Quantification of In-Process Samples of a Rotavirus Vaccine

A Clinical Nursing Care Study on the Prevalence of Rotavirus Infection and Acute Diarrhea in Vaccinated Chinese Pediatric Population from 2019–2022

Contact Info

Product

Resources

About