The Performance of Hancock Porcine-Valved Dacron Conduit for Right Ventricular Outflow Tract Reconstruction

Belli, Emrè; Salihoğlu, Ece; Léobon, Bertrand; Roubertie, François; Ly, Mohamed; Roussin, Régine; Sérraf, Alain

doi:10.1016/j.athoracsur.2009.09.046

Cited by 45 publications

(36 citation statements)

References 21 publications

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“…Several materials have been tested clinically for reconstructing the RVOT, [22][23][24][25][26][27][28][29] but their common limitation is the lack of a growth potential that leads to reoperations, with their attendant risk of increased morbidity and mortality.…”

Section: Discussionmentioning

confidence: 99%

Polymer-Based Reconstruction of the Inferior Vena Cava in Rat: Stem Cells or RGD Peptide?

Pontailler

Illangakoon

Williams

et al. 2015

Tissue Engineering Part A

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As part of a program targeted at developing a resorbable valved tube for replacement of the right ventricular outflow tract, we compared three biopolymers (polyurethane [PU], polyhydroxyalkanoate (the poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-4-hydroxyvalerate) [PHBVV]), and polydioxanone [PDO]) and two biofunctionalization techniques (using adipose-derived stem cells [ADSCs] or the arginine-glycine-aspartate [RGD] peptide) in a rat model of partial inferior vena cava (IVC) replacement. Fifty-three Wistar rats first underwent partial replacement of the IVC with an acellular electrospun PDO, PU, or PHBVV patch, and 31 nude rats subsequently underwent the same procedure using a PDO patch biofunctionalized either by ADSC or RGD. Results were assessed both in vitro (proliferation and survival of ADSC seeded onto the different materials) and in vivo by magnetic resonance imaging ( MRI), histology, immunohistochemistry [against markers of vascular cells (von Willebrand factor [vWF], smooth muscle actin [SMA]), and macrophages ([ED1 and ED2] immunostaining)], and enzyme-linked immunosorbent assay (ELISA; for the expression of various cytokines and inducible NO synthase). PDO showed the best in vitro properties. Six weeks after implantation, MRI did not detect significant luminal changes in any group. All biopolymers were evenly lined by vWF-positive cells, but only PDO and PHBVV showed a continuous layer of SMA-positive cells at 3 months. PU patches resulted in a marked granulomatous inflammatory reaction. The ADSC and RGD biofunctionalization yielded similar outcomes. These data confirm the good biocompatibility of PDO and support the concept that appropriately peptide-functionalized polymers may be successfully substituted for cell-loaded materials.

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Section: Discussionmentioning

confidence: 99%

Polymer-Based Reconstruction of the Inferior Vena Cava in Rat: Stem Cells or RGD Peptide?

Pontailler

Illangakoon

Williams

et al. 2015

Tissue Engineering Part A

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“…Right ventricular outflow tract reconstruction (pulmonary valve replacement) is accomplished with a variety of bioprosthetic valves and valved conduits, including allografts and both porcine and bovine xenografts. [318][319][320][321][322][323][324] The risk of systemic embolization is essentially nonexistent. Some authors have reported using aspirin after implantation of bioprosthetic valves in the pulmonary position, but this practice is uncommon.…”

Section: Recommendations For Long-term Prevention Ofmentioning

confidence: 99%

“…318,320 The risk of thromboembolic complications after bioprosthetic replacement of the pulmonary valve appears to be very low, and for the patient without additional risk factors, there is no indication for anticoagulation. [318][319][320][321]323,324 The use of mechanical valves for pulmonary valve replacement has been reported. In 2 series totaling 13 patients in whom aspirin and/or dipyramidole were used without VKAs, early valve failure was common, occurring in 7 of 13 patients within 1 year of valve implantation.…”

Section: Recommendations For Long-term Prevention Ofmentioning

confidence: 99%

Prevention and Treatment of Thrombosis in Pediatric and Congenital Heart Disease

Giglia¹,

Massicotte²,

Tweddell³

et al. 2013

Circulation

283

245

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“…В последнее время появились сообщения о приемле-мых отдаленных результатах использования дакронового кондуита Hancock (Medtronic Inc., Minneapolis, MN) [13,21,27]. E. Belli и соавт.…”

Section: дакроновые кондуитыunclassified

Valved conduits in pediatric cardiac surgery

Soynov

Zhuravleva

Kulyabin

et al. 2018

Khir. Z. im. N.I. Pirogova

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The Performance of Hancock Porcine-Valved Dacron Conduit for Right Ventricular Outflow Tract Reconstruction

Cited by 45 publications

References 21 publications

Polymer-Based Reconstruction of the Inferior Vena Cava in Rat: Stem Cells or RGD Peptide?

Polymer-Based Reconstruction of the Inferior Vena Cava in Rat: Stem Cells or RGD Peptide?

Prevention and Treatment of Thrombosis in Pediatric and Congenital Heart Disease

Valved conduits in pediatric cardiac surgery

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